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Cited by 254

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Differential expression of TGF beta isoforms in murine palatogenesis

Fitzpatrick, David R., Denhez, Fabienne, Kondaiah, Paturu, Akhurst, Rosemary J.·1990·Development

Abstract

We have studied the expression of genes encoding transforming growth factors (TGFs) beta1, beta2 and beta3 during development of the secondary palate in the mouse from 11.5 to 15.5 days postcoitum using in situ hybridisation. The RNA detected at the earliest developmental stage is TGF beta3, which is localised in the epithelial component of the vertical palatal shelf. This expression continues in the horizontal palatal shelf, predominantly in the medial edge epithelium, and is lost as the epithelial seam disrupts, soon after palatal shelf fusion. TGF betal RNA is expressed with the same epithelial pattern as TGF beta3, but is not detectable until the horizontal palatal shelf stage. TGF beta2 RNA is localised to the palatal mesenchyme underlying the medial edge epithelia in the horizontal shelves and in the early postfusion palate. The temporal and spatial distribution of TGF betal, beta! and beta3 RNAs in the developing palate, together with a knowledge of in vitro TGF beta biological activities, suggests an important role for TGF beta isoforms in this developmental pro cess.

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Crossref · 10.1242/dev.109.3.585

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Metadata

Authors
Fitzpatrick, D. R., Denhez, F., Kondaiah, P., & Akhurst, R. J.
Venue
Development
Published
1990-07-01
Volume
109
Issue
3
Pages
585-595
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W1858922792
Cited by
254
References
3
FWCI
10.73
Type
journal article
Language
en
Open access
closed

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