TGF-β3 and cancer: A review

Laverty, H.G.; Wakefield, L.M.; Occleston, N.L.; O’Kane, S.; Ferguson, M.W.J.

doi:10.1016/j.cytogfr.2009.07.002

Cited by 111TGF-β signaling in diseasesLiver physiology and pathologyT-cell and B-cell Immunology

TGF-β3 and cancer: A review

Open access

Laverty, H.G., Wakefield, L.M., Occleston, N.L., O’Kane, S., Ferguson, M.W.J.·2009·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2009.07.002PMC PMC7294566

Open this paper in CoChat — free account

Abstract

With the development of growth factors and growth factor modulators as therapeutics for a range of disorders, it is prudent to consider whether modulating the growth factor profile in a tissue can influence tumour initiation or progression. As recombinant human TGF-beta3 (avotermin) is being developed for the improvement of scarring in the skin it is important to understand the role, if any, of this cytokine in tumour progression. Elevated levels of TGF-beta3 expression detected in late-stage tumours have linked this cytokine with tumourigenesis, although functional data to support a causative role are lacking. While it has proved tempting for researchers to interpret a 'correlation' as a 'cause' of disease, what has often been overlooked is the normal biological role of TGF-beta3 in processes that are often subverted in tumourigenesis. Clarifying the role of this cytokine is complicated by inappropriate extrapolation of the data relating to TGF-beta1 in tumourigenesis, despite marked differences in biology between the TGF-beta isoforms. Indeed, published studies have indicated that TGF-beta3 may actually play a protective role against tumourigenesis in a range of tissues including the skin, breast, oral and gastric mucosa. Based on currently available data it is reasonable to hypothesize that administration of acute low doses of exogenous TGF-beta3 is unlikely to influence tumour initiation or progression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cytogfr.2009.07.002

Cites

164 of 164 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A TβRII receptor antibody (IMC-TRI, LY3022859) under development by Eli Lilly showed efficacy in preclinical evaluation against mammary cancer.
“Finally, a TβRII receptor antibody (IMC-TRI, LY3022859) under development by Eli Lilly showed efficacy in preclinical evaluation against mammary cancer304”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [304]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536 · see citing works
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
van de Vijver, M. J., He, Y. D., Veer, L. V. ‘., Dai, H. A., Hart, A. A. M., Voskuil, D. W., Schreiber, G. J., Peterse, J. L., Roberts, C., Marton, M. J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021967 · Cited by 6,411 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works
TGFβ in Cancer
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907 · see citing works
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985 · see citing works
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works
Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma
Balch, C. M., Buzaid, A. C., Soong, S., Atkins, M. B., Cascinelli, N., Coit, D. G., Fleming, I. D., Gershenwald, J. E., Houghton, A. N., Kirkwood, J. M., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.16.3635 · Cited by 2,627 · see citing works
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275 · see citing works
Putting tumours in context
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works
Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis
Sotiriou, C. P., Wirapati, P., Loi, S., Harris, A. L., Fox, S., Smeds, J., Nordgren, H., Farmer, P. J., Praz, V., Haibe‐Kains, B., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj052 · Cited by 2,060 · see citing works
Delineation of prognostic biomarkers in prostate cancer
Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R. B., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., & Chinnaiyan, A. M. (2001) · Nature · doi:10.1038/35090585 · Cited by 1,675 · see citing works
Making sense of latent TGFβ activation
Annes, J. P., Munger, J. S., & Rifkin, D. B. (2002) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,624 · see citing works
Reproductive Factors and Breast Cancer
Kelsey, J. L., Gammon, M. D., & John, E. M. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036115 · Cited by 1,452 · see citing works
TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes
Sanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447 · see citing works
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
Miller, L. D., Smeds, J., George, J., Vega, V. B., Vergara, L. A., Ploner, A., Yudi Pawitan, Y., Hall, P. N., Klaar, S., Liu, E. T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506230102 · Cited by 1,269 · see citing works
Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
Shah, M., Foreman, D. M., & Ferguson, M. W. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.3.985 · Cited by 1,168 · see citing works
Self-citation
Type beta transforming growth factor: a bifunctional regulator of cellular growth.
Roberts, A. B., Anzano, M. A., Wakefield, L. M., Roche, N. S., Stern, D. F., & Sporn, M. B. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.119 · Cited by 1,093 · see citing works
Self-citation
Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction
Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,031 · see citing works
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029 · see citing works
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
Yin, J. J., Selander, K. S., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., Massagué, J., Mundy, G. R., & Guise, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3523 · Cited by 988 · see citing works
Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series
Desmedt, C., Piette, F., Loi, S., Wang, Y., Lallemand, F., Haibe‐Kains, B., Viale, G., Delorenzi, M., Zhang, Y., Saghatchian, M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2765 · Cited by 970 · see citing works
Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds
Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K. D., Chi, J., van de Rijn, M., Botstein, D., & Brown, P. O. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020007 · Cited by 952 · see citing works
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 947 · see citing works
Integrative molecular concept modeling of prostate cancer progression
Tomlins, S. A., Mehra, R., Rhodes, D. R., Cao, X., Wang, L., Dhanasekaran, S. M., Sundaram, S. K., Wei, J. T., Rubin, M. A., Pienta, K. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1935 · Cited by 909 · see citing works
Transforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908 · see citing works
Self-citation
Betaglycan presents ligand to the TGFβ signaling receptor
López‐Casillas, F., Wrana, J. L., & Massagué, J. (1993) · Cell · doi:10.1016/0092-8674(93)90368-z · Cited by 892 · see citing works
TGF-β signaling: positive and negative effects on tumorigenesis
Wakefield, L. M. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00259-3 · Cited by 827 · see citing works
Self-citation
Scar–free healing: from embryonic mechanisms to adult therapeutic intervention
Ferguson, M. W. J., & O'Kane, S. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1475 · Cited by 812 · see citing works
Self-citation
TGF- β signaling in cancer – a double-edged sword
Akhurst, R. J., & Derynck, R. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02130-4 · Cited by 756 · see citing works
Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic Death
Onken, M. D., Worley, L. A., Ehlers, J. P., & Harbour, J. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1750 · Cited by 753 · see citing works
Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer
Ivshina, A. V., George, J., Sen'ko, O. V., Mow, B. M. F., Putti, T. C., Smeds, J., Lindahl, T., Yudi Pawitan, Y., Hall, P. N., Nordgren, H., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4414 · Cited by 751 · see citing works
The two faces of transforming growth factor β in carcinogenesis
Roberts, A. B., & Wakefield, L. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633291100 · Cited by 747 · see citing works
Self-citation
Role of Transforming Growth Factor Beta in Human Cancer
Elliott, R. L., & Blobe, G. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.047 · Cited by 705 · see citing works
Smad3 Mutant Mice Develop Metastatic Colorectal Cancer
Zhu, Y., Richardson, J. A., Parada, L. F., & Graff, J. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81730-4 · Cited by 671 · see citing works
TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628 · see citing works
Differentiation of the mammary gland and susceptibility to carcinogenesis
Russo, J., Tay, L. K., & Russo, I. H. (1982) · Breast Cancer Research and Treatment · doi:10.1007/bf01805718 · Cited by 628 · see citing works
Control of scarring in adult wounds by neutralising antibody to transforming growth factor β
Shah, M., Foreman, D. M., & Ferguson, M. W. J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90009-r · Cited by 618 · see citing works
Self-citation
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature
Hoek, K. S., Schlegel, N. C., Brafford, P. A., Sucker, A., Ugurel, S., Kumar, R., Weber, B. L., Nathanson, K. L., Phillips, D. J., Herlyn, M., et al. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00322.x · Cited by 543 · see citing works
Epidemiologic aspects of uveal melanoma
Egan, K. M., Seddon, J. M., Glynn, R. J., Gragoudas, E. S., & Albert, D. M. (1988) · Survey of Ophthalmology · doi:10.1016/0039-6257(88)90173-7 · Cited by 528 · see citing works
Role of Transforming Growth Factor-beta Signaling in Cancer
de Caestecker, M. P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.17.1388 · Cited by 521 · see citing works
Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins.
Welsch, C. W. (1985) · PubMed · Cited by 496 · see citing works
Neutralising antibody to TGF-β1,2 reduces cutaneous scarring in adult rodents
Shah, M., Foreman, D. M., & Ferguson, M. W. J. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.5.1137 · Cited by 490 · see citing works
Self-citation
Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation
Lindholm, D., Ċastrén, E., Kiefer, R., Zafra, F., & Thoenen, H. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.2.395 · Cited by 487 · see citing works
Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily
Daopin, S., Piez, K. A., Ogawa, Y., & Davies, D. R. (1992) · Science · doi:10.1126/science.1631557 · Cited by 440 · see citing works
Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations
Prud’homme, G. J. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700669 · Cited by 424 · see citing works
Mammary gland neoplasia in long-term rodent studies.
Russo, I. H., & Russo, J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104938 · Cited by 410 · see citing works
Malignant MCF10CA1 Cell Lines Derived from Premalignant Human Breast Epithelial MCF10AT Cells
Santner, S. J., Dawson, P. J., Tait, L. R., Soule, H. D., Eliason, J. F., Mohamed, A. N., Wolman, S. R., Heppner, G. H., & Miller, F. R. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1006461422273 · Cited by 409 · see citing works
Immunohistochemical localization of growth factors in fetal wound healing
Whitby, D. J., & Ferguson, M. W. J. (1991) · Developmental Biology · doi:10.1016/s0012-1606(05)80018-1 · Cited by 409 · see citing works
Self-citation
TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
Tang, B., Vu, M. A., Booker, T., Santner, S. J., Miller, F. R., Anver, M. R., & Wakefield, L. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18899 · Cited by 391 · see citing works
Self-citation
The extracellular matrix of lip wounds in fetal, neonatal and adult mice
Whitby, D. J., & Ferguson, M. W. J. (1991) · Development · doi:10.1242/dev.112.2.651 · Cited by 390 · see citing works
Self-citation
Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.
Arteaga, C. L., Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendly, B. M., & Forbes, J. T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116871 · Cited by 359 · see citing works
TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
Tang, B., Vu, M. A., Booker, T., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318899 · Cited by 329 · see citing works
Pathogenesis of cleft palate in TGF-β3 knockout mice
Taya, Y., O’Kane, S., & Ferguson, M. W. J. (1999) · Development · doi:10.1242/dev.126.17.3869 · Cited by 326 · see citing works
Self-citation
Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities.
Tschentscher, F., Hüsing, J., Hölter, T., Kruse, E., Dresen, I. G., Jöckel, K., Anastassiou, G., Schilling, H., Bornfeld, N., Horsthemke, B., et al. (2003) · PubMed · Cited by 324 · see citing works
The role for transforming growth factor-beta (TGF-beta) in human cancer.
Gold, L. I. (1999) · PubMed · Cited by 322 · see citing works
MCF10AT: a model for the evolution of cancer from proliferative breast disease.
Dawson, P. J., Wolman, S. R., Tait, L. R., Heppner, G. H., & Miller, F. R. (1996) · Europe PMC (PubMed Central) · Cited by 314 · see citing works
Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.
Vanaja, D. K., Cheville, J. C., Iturria, S., & Young, C. Y. F. (2003) · PubMed · Cited by 313 · see citing works
Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy
Vargas-Roig, L. M., Gago, F. E., Tello, O. M., Aznar, J. C., & Ciocca, D. R. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19981023)79:5 · Cited by 302 · see citing works
Sex-Determining Region Y Box 4 Is a Transforming Oncogene in Human Prostate Cancer Cells
Liu, P., Ramachandran, S., Ali‐Seyed, M., Scharer, C. D., Laycock, N., Dalton, W. B., Williams, H. C., Karanam, S., Datta, M. W., Jaye, D. L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3055 · Cited by 296 · see citing works
Localization and actions of transforming growth factor-<i>β</i>s in the embryonic nervous system
Flanders, K. C., Lüdecke, G., Engels, S., Cissel, D. S., Roberts, A. B., Kondaiah, P., Lafyatis, R., Sporn, M. B., & Unsicker, K. (1991) · Development · doi:10.1242/dev.113.1.183 · Cited by 295 · see citing works
Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies
Ferguson, M. W. J., Duncan, J. A. L., Bond, J. S., Bush, J., Durani, P., So, K., Taylor, L., Chantrey, J., Mason, T., James, G., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60322-6 · Cited by 290 · see citing works
Self-citation
Transforming Growth Factor-β Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways
Käkönen, S.-M., Selander, K. S., Chirgwin, J. M., Yin, J. J., Burns, S. S., Rankin, W. A., Grubbs, B. G., Dallas, M., Cui, Y., & Guise, T. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202561200 · Cited by 277 · see citing works
Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2
Graycar, J. L., Miller, D. A., Arrick, B. A., Lyons, R. M., Moses, H. L., & Derynck, R. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-12-1977 · Cited by 266 · see citing works
Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.
Potts, J. D., Dagle, J. M., Walder, J. A., Weeks, D. L., & Runyan, R. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1516 · Cited by 260 · see citing works
Differential expression of TGF beta isoforms in murine palatogenesis
FitzPatrick, D. R., Denhez, F., Kondaiah, P., & Akhurst, R. J. (1990) · Development · doi:10.1242/dev.109.3.585 · Cited by 252 · see citing works
Effect of Conditional Knockout of the Type II TGF-β Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis
Forrester, E., Chytil, A., Bierie, B., Aakre, M. E., Gorska, A. E., Sharif‐Afshar, A., Muller, W. J., & Moses, H. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3272 · Cited by 248 · see citing works
GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of drosophila
Manseau, L. J., Baradaran, A., Brower, D. L., Budhu, A., Elefant, F., Phan, H., Philp, A. V., Yang, M., Glover, D. M., Kaiser, K., et al. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199707)209:3 · Cited by 241 · see citing works
Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis.
Russo, J., & Russo, I. H. (1980) · PubMed · Cited by 234 · see citing works
Parity, age at first and last birth, and risk of breast cancer: A population-based study in Sweden
Lambe, M. P., Hsieh, C., Chan, H.-W., Ekbom, A., Trichopoulos, D., & Adami, H. (1996) · Breast Cancer Research and Treatment · doi:10.1007/bf01806150 · Cited by 234 · see citing works
TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis
Akhurst, R. J., Lehnert, S. A., Faissner, A., & Duffie, E. (1990) · Development · doi:10.1242/dev.108.4.645 · Cited by 233 · see citing works
Tissue-Wide Expression Profiling Using cDNA Subtraction and Microarrays to Identify Tumor-Specific Genes
Amatschek, S., Koenig, U., Auer, H., Steinlein, P., Pacher, M., Gruenfelder, A., Dekan, G., Vogl, S. E., Kubista, E., Heider, K., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2361 · Cited by 230 · see citing works
Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.
Engle, S. J., Hoying, J. B., Boivin, G. P., Ormsby, I., Gartside, P. S., & Doetschman, T. C. (1999) · PubMed · Cited by 216 · see citing works
Crystal structure of the human TβR2 ectodomain–TGF-β3 complex
Hart, P. J., Deep, S., Taylor, A. B., Shu, Z., Hinck, C. S., & Hinck, A. P. (2002) · Nature Structural Biology · doi:10.1038/nsb766 · Cited by 214 · see citing works
A Case-Control Study of Oral Contraceptive Use and Invasive Epithelial Ovarian Cancer
Rosenberg, L. A., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Lewis, J. L., Strom, B. L., Harlap, S., & Shapiro, S. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117055 · Cited by 195 · see citing works
Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.
Dickson, R. B., Kasid, A., Huff, K. K., Bates, S. E., Knabbe, C., Bronzert, D. A., Gelmann, E. P., & Lippman, M. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.3.837 · Cited by 194 · see citing works
Malignant melanoma: modern black plague and genetic black boxPreprint
Chin, L., Merlino, G. T., & DePinho, R. A. (1998) · Genes & Development · doi:10.1101/gad.12.22.3467 · Cited by 193 · see citing works
DNA Labeling Index and Structure of the Rat Mammary Gland as Determinants of Its Susceptibility to Carcinogenesis 2
Russo, J., & Russo, I. H. (1978) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/61.6.1451 · Cited by 193 · see citing works
Transforming growth factor β3 induces cell death during the first stage of mammary gland involution
Nguyen, A., & Pollard, J. W. (2000) · Development · doi:10.1242/dev.127.14.3107 · Cited by 179 · see citing works
Functional Gene Expression Analysis Uncovers Phenotypic Switch in Aggressive Uveal Melanomas
Onken, M. D., Ehlers, J. P., Worley, L. A., Makita, J., Yokota, Y., & Harbour, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4196 · Cited by 178 · see citing works
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Tian, F., Byfield, S. D., Parks, W. T., Yoo, S. S., Felici, A., Tang, B., Piek, E., Wakefield, L. M., & Roberts, A. B. (2003) · PubMed · Cited by 177 · see citing works
Self-citation
Site‐specific production of TGF‐β in oral mucosal and cutaneous wounds
Schrementi, M. E., Ferreira, A. M., Zender, C. A., & DiPietro, L. A. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00320.x · Cited by 177 · see citing works
Validation of 70-gene prognosis signature in node-negative breast cancer
Bueno-de-Mesquita, J. M., Linn, S., Keijzer, R., Wesseling, J., Nuyten, D. S. A., van Krimpen, C., Meijers, C., de Graaf, P. W., Bos, M. M. E. M., Hart, A. A. M., et al. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0191-2 · Cited by 177 · see citing works
Persistent Parity-Induced Changes in Growth Factors, TGF-β3, and Differentiation in the Rodent Mammary Gland
D’Cruz, C. M., Moody, S. E., Master, S. R., Hartman, J. L., Keiper, E. A., Imielinski, M. B., Cox, J. D., Wang, J., Ha, S. I., Keister, B. A., et al. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0073 · Cited by 175 · see citing works
Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3
Ask, K., Bonniaud, P., Maass, K., Eickelberg, O., Margetts, P. J., Warburton, D., Groffen, J., Gauldie, J., & Kolb, M. R. J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.08.016 · Cited by 172 · see citing works
Susceptibility of the mammary gland to carcinogenesis: I Differentiation of the mammary gland as determinant of tumor incidence and type of lesion.
Russo, J., Wilgus, G. S., & Russo, I. H. (1979) · PubMed · Cited by 170 · see citing works
Transforming Growth Factor β1: Three-Dimensional Structure in Solution and Comparison with the X-ray Structure of Transforming Growth Factor β2,
Hinck, A. P., Archer, S. J., Qian, S. W., Roberts, A. B., Sporn, M. B., Weatherbee, J. A., Tsang, M., Lucas, R., Zhang, B.-L., Wenker, J., et al. (1996) · Biochemistry · doi:10.1021/bi9604946 · Cited by 168 · see citing works
Predicting protein interaction sites: binding hot-spots in protein–protein and protein–ligand interfaces
Burgoyne, N. J., & Jackson, R. M. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl079 · Cited by 166 · see citing works
Transforming growth factors.
Roberts, A. B., & Sporn, M. B. (1985) · PubMed · Cited by 163 · see citing works
Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-β
Dumont, N., & Arteaga, C. L. (2000) · Breast Cancer Research · doi:10.1186/bcr44 · Cited by 158 · see citing works
Transforming Growth Factor β Receptor Type II Inactivation Promotes the Establishment and Progression of Colon Cancer
Biswas, S., Chytil, A. M., Washington, K., Romero–Gallo, J., Gorska, A. E., Wirth, P. S., Gautam, S., Moses, H. L., & Grady, W. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3255 · Cited by 153 · see citing works
The crystal structure of TGF‐β3 and comparison to TGF‐β2: Implications for receptor binding
Mittl, P. R. E., Priestle, J. P., Cox, D., McMaster, G., Cerletti, N., & Grütter, M. G. (1996) · Protein Science · doi:10.1002/pro.5560050705 · Cited by 147 · see citing works
Induction of growth factor RNA expression in human malignant melanoma: markers of transformation.
Albino, A. P., Davis, B. M., & Nanus, D. M. (1991) · PubMed · Cited by 146 · see citing works
Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion
Brunet, C. L., Sharpe, P. M., & Ferguson, M. W. J. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7669547 · Cited by 142 · see citing works
Self-citation
Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis
Luo, J., Dunn, T. A., Ewing, C. M., Sauvageot, J., Chen, Y., Trent, J. M., & Isaacs, W. B. (2002) · The Prostate · doi:10.1002/pros.10087 · Cited by 138 · see citing works
Elevated serum levels of transforming growth factor-?1 in patients with colorectal carcinoma
Shim, K. S., Kim, K. H., Han, W. S., & Park, E. B. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990201)85:3 · Cited by 137 · see citing works
Human Leiomyoma Smooth Muscle Cells Show Increased Expression of Transforming Growth Factor-β3 (TGFβ3) and Altered Responses to the Antiproliferative Effects of TGFβ 1
Lee, B. S., & Nowak, R. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7237 · Cited by 137 · see citing works
Genetic architecture of mouse skin inflammation and tumour susceptibility
Quigley, D. A., To, M. D., Pérez‐Losada, J., Pelorosso, F. G., Mao, J., Nagase, H., Ginzinger, D. G., & Balmain, A. (2009) · Nature · doi:10.1038/nature07683 · Cited by 137 · see citing works
The transforming growth factors
Massagué, J. (1985) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(85)90141-0 · Cited by 133 · see citing works
Induction of papillomas with a high probability of conversion to malignancy
Hennings, H., Shores, R., Mitchell, P., Spangler, E. F., & Yuspa, S. H. (1985) · Carcinogenesis · doi:10.1093/carcin/6.11.1607 · Cited by 132 · see citing works
Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells.
Rodeck, U., Bossler, A., Graeven, U., Fox, F. E., Nowell̀, P. C., Knabbe, C., & Kari, C. (1994) · PubMed · Cited by 123 · see citing works
TGF‐βS and TGF‐β type II receptor in human epidermis: Differential expression in acute and chronic skin wounds
Schmid, P., Cox, D., Bilbe, G., McMaster, G., Morrison, C., Stähelin, H. B., Lüscher, N. J., & Seiler, W. O. (1993) · The Journal of Pathology · doi:10.1002/path.1711710307 · Cited by 122 · see citing works
Latent-TGF-β: An overview
Lawrence, D. A. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1010819716023 · Cited by 117 · see citing works
Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies
Gallagher, W. M., Bergin, O. E., Rafferty, M., Kelly, Z. D., Nolan, I.-M., Fox, E., Culhane, A. C., McArdle, L., Fraga, M. F., Hughes, L., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi152 · Cited by 116 · see citing works
Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis
Lakshmanaswamy, R., Guzman, R. C., Yang, J., Thórdarson, G., Talamantes, F. J., & Nandi, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201393798 · Cited by 114 · see citing works
Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy
Sinha, D., Pazik, J., & Dao, T. L. (1988) · British Journal of Cancer · doi:10.1038/bjc.1988.88 · Cited by 109 · see citing works
Progestin-Induced Apoptosis in the Macaque Ovarian Epithelium: Differential Regulation of Transforming Growth Factor-
Rodriguez, G. C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.1.50 · Cited by 109 · see citing works
Melanoma-associated expression of transforming growth factor-beta isoforms.
Belle, P. A. V., Rodeck, U., Nuamah, I. F., Halpern, A. C., & Elder, D. E. (1996) · Europe PMC (PubMed Central) · Cited by 103 · see citing works
Role of TGF-? in immune-evasion of cancer
Beck, C., Schreiber, H. W., & Rowley, D. A. (2001) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010215)52:4 · Cited by 103 · see citing works
Recombinant Transforming Growth Factor Type β3: Biological Activities and Receptor-Binding Properties in Isolated Bone Cells
ten Dijke, P., Iwata, K. K., Goddard, C. P., Pieler, C., CANALIS, E. M., McCarthy, T. L., & Centrella, M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4473-4479.1990 · Cited by 103 · see citing works
SKI activates Wnt/beta-catenin signaling in human melanoma.
Chen, D., Xu, W., Bales, E. S., Colmenares, C., Conacci‐Sorrell, M., Ishii, S., Stavnezer, E., Campisi, J., Fisher, D. E., Ben‐Ze'ev, A., et al. (2003) · PubMed · Cited by 102 · see citing works
Protective effects of pregnancy and lactation against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats
Yang, J., Yoshizawa, K., Nandi, S., & Tsubura, A. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.623 · Cited by 101 · see citing works
The Loss of TGF-β Signaling Promotes Prostate Cancer Metastasis
Tu, W. H., Thomas, T. Z., Masumori, N., Bhowmick, N. A., Gorska, A. E., Shyr, Y., Kasper, S., Case, T., Roberts, R. L., Shappell, S. B., et al. (2003) · Neoplasia · doi:10.1016/s1476-5586(03)80058-1 · Cited by 98 · see citing works
Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms
Jacobsen, S. E. W., Keller, J. R., Ruscetti, F., Kondaiah, P., Roberts, A. B., & Falk, L. (1991) · Blood · doi:10.1182/blood.v78.9.2239.2239 · Cited by 96 · see citing works
Prognostic significance of TGF beta 1 and TGF beta 3 in human breast carcinoma.
Ghellal, A., Li, C., Hayes, M., Byrne, G. J., Bundred, N. J., & Kumar, S. (2000) · PubMed · Cited by 90 · see citing works
Three Key Residues Underlie the Differential Affinity of the TGFβ Isoforms for the TGFβ Type II Receptor
Crescenzo, G. D., Hinck, C. S., Shu, Z., Zúñiga, J. E., Yang, J., Tang, Y., Baardsnes, J., Mendoza, V., Sun, L., López‐Casillas, F., et al. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.10.022 · Cited by 90 · see citing works
Tumor angiogenesis as a prognostic factor in ovarian carcinoma
Schoell, W., Pieber, D., Reich, O., LAHOUSEN, M., Janicek, M. F., Güçer, F., & Winter, R. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971215)80:12 · Cited by 88 · see citing works
Protection Against Mucosal Injury By Growth Factors and Cytokines
Booth, D., & Potten, C. S. (2001) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a003433 · Cited by 82 · see citing works
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma
Pedersen, T. X., Leethanakul, C., Patel, V., Mitola, D. J., Lund, L. R., Danø, K., Johnsen, M., Gutkind, J. S., & Bugge, T. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206614 · Cited by 80 · see citing works
Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells.
ten Dijke, P., Iwata, K. K., Goddard, C., Pieler, C., CANALIS, E. M., McCarthy, T. L., & Centrella, M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4473 · Cited by 80 · see citing works
Identification of differentially expressed genes in organ‐confined prostate cancer by gene expression array
Chetcuti, A., Margan, S. H., Mann, S., Russell, P., Handelsman, D. J., Rogers, J. H., & Dong, Q. (2001) · The Prostate · doi:10.1002/pros.1056 · Cited by 70 · see citing works
Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells.
Rodeck, U., Nishiyama, T., & Mauviel, A. (1999) · PubMed · Cited by 70 · see citing works
Experimental Manipulation of Transforming Growth Factor-β Isoforms Significantly Affects Adhesion Formation in a Murine Surgical Model
Gorvy, D. A., Herrick, S. E., Shah, M., & Ferguson, M. W. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61190-x · Cited by 68 · see citing works
Self-citation
Latent forms of TGF‐β: Molecular Structure and Mechanisms of Activation
Miyazono, K., & Heldin, C. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514061.ch6 · Cited by 67 · see citing works
Differential Effects of TGF-β1 and TGF-β3 on Chondrogenesis in Posterofrontal Cranial Suture–Derived Mesenchymal Cells In Vitro
James, A. W., Xu, Y., Lee, J. K., Wang, R., & Longaker, M. T. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181904c19 · Cited by 67 · see citing works
Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants
Yang, L., & Kaartinen, V. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.034 · Cited by 67 · see citing works
Formation and removal of 7,12-dimethylbenz[a]anthracene -- nucleic acid adducts in rat mammary epithelial cells with different susceptibility to carcinogenesis
Tay, L. K., & Russo, J. (1981) · Carcinogenesis · doi:10.1093/carcin/2.12.1327 · Cited by 67 · see citing works
TGF-? isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis
Gold, L. I., Jussila, T., Fusenig, N. E., & Stenb�ck, F. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200004)190:5 · Cited by 57 · see citing works
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Grütter, C., Wilkinson, T. C. I., Turner, R., Podichetty, S., Finch, D. K., McCourt, M., Loning, S., Jermutus, L., & Grütter, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807200106 · Cited by 56 · see citing works
Differential expression of transforming growth factors-β1, -β2 and -β3 in human colon carcinoma
Bellone, G., Carbone, A., Tibaudi, D., Mauri, F. A., Ferrero, I., Smirne, C., Suman, F. R., Rivetti, C., Migliaretti, G., Camandona, M., et al. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00391-9 · Cited by 55 · see citing works
In situ analysis of transforming growth factor-βs (TGF-β1, TGF-β2, TGF-β3and TGF-3 type II receptor expression in malignant melanoma
Schmid, P., Itin, P. H., & Rufli, T. (1995) · Carcinogenesis · doi:10.1093/carcin/16.7.1499 · Cited by 53 · see citing works
Association Between Microarray Gene Expression Signature and Extravascular Matrix Patterns in Primary Uveal Melanomas
Onken, M. D., Lin, A., Worley, L. A., Folberg, R., & Harbour, J. W. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.04.024 · Cited by 51 · see citing works
TGFβ1, TGFβ2, and TGFβ3 Protein Expression in Gastric Carcinomas: Correlation with Prognostics Factors and Patient Survival
Vagenas, K., Spyropoulos, C., Gavala, V., & Tsamandas, A. C. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.10.005 · Cited by 51 · see citing works
Opposite Regulation of Transforming Growth Factors-β2 and -β3 Expression in the Human Endometrium
Chevronnay, H. P. G., Cornet, P. B., Delvaux, D., Lemoine, P., Courtoy, P. J., Henriet, P., & Marbaix, É. (2007) · Endocrinology · doi:10.1210/en.2007-0849 · Cited by 50 · see citing works
Suppression of carcinogenesis: a role for TGF-beta and related molecules in prevention of cancer.
Wakefield, L. M., & Sporn, M. B. (1990) · PubMed · Cited by 48 · see citing works
Self-citation
Immunolocalizations of VEGF, its receptors flt-1, KDR and TGF-beta's in epithelial ovarian tumors.
Inan, S., Vatansever, S., Çelik-Özenci, Ç., Sanci, M., Dicle, N., & Demir, R. (2006) · PubMed · doi:10.14670/hh-21.1055 · Cited by 45 · see citing works
7,12-Dimethylbenz[a]anthracene-Induced DNA Binding and Repair Synthesis in Susceptible and Nonsusceptible Mammary Epithelial Cells in Culture 2
Tay, L. K., & Russo, J. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.1.155 · Cited by 45 · see citing works
The Role of Serum TGF-β Isoforms as Potential Markers of Osteoporosis
Grainger, D. J., Percival, J., Chiano, M., & Spector, T. D. (1999) · Osteoporosis International · doi:10.1007/s001980050163 · Cited by 44 · see citing works
Paracrine and autocrine regulation of human melanocyte and melanoma cell growth by transforming growth factor beta in vitro.
Krasagakis, K., Garbe, C., Schrier, P. I., & Orfanos, C. E. (1994) · PubMed · Cited by 42 · see citing works
TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3.
Jacobsen, S. E. W., Ruscetti, F. W., Roberts, A. B., & Keller, J. R. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4534 · Cited by 41 · see citing works
A transforming growth factor .beta. (TGF-.beta.) receptor from human placenta-exhibits a greater affinity for TGF-.beta.2 than for TGF-.beta.1
Mitchell, E. J., & O'Connor‐McCourt, M. D. (1991) · Biochemistry · doi:10.1021/bi00231a034 · Cited by 39 · see citing works
Human Leiomyoma Smooth Muscle Cells Show Increased Expression of Transforming Growth Factor- 3 (TGF 3) and Altered Responses to the Antiproliferative Effects of TGF
Lee, B.-S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.913 · Cited by 38 · see citing works
Periodontal tissue regeneration by recombinant human transforming growth factor‐β3 in Papio ursinus
Teare, J., Ramoshebi, L. N., & Ripamonti, U. (2007) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2007.00987.x · Cited by 34 · see citing works
Dynamics-modulated Biological Activity of Transforming Growth Factor β3
Bocharov, E. V., Korzhnev, D. M., Blommers, M. J. J., Arvinte, T., Orekhov, V., Billeter, M., & Arseniev, A. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206274200 · Cited by 33 · see citing works
Synthesis and secretion of transforming growth factor beta isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen
Benson, J., Wakefield, L. M., Baum, M., & Colletta, A. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.365 · Cited by 32 · see citing works
Self-citation
Expression and secretion of TGF-beta isoforms and expression of TGF-beta-receptors I, II and III in normal and neoplastic human breast.
Chakravarthy, D., Green, A. R., Green, V. L., Kerin, M. J., & Speirs, V. (1999) · International Journal of Oncology · doi:10.3892/ijo.15.1.187 · Cited by 32 · see citing works
Differential Binding of Transforming Growth Factor-β1, -β2, and -β3 by Fibroblasts and Epithelial Cells Measured by Affinity Cross-Linking of Cell Surface Receptors
Lyons, R. M., Miller, D. A., Graycar, J. L., Moses, H. L., & Derynck, R. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1887 · Cited by 31 · see citing works
Hormone levels and mammary epithelial cell proliferation in rats treated with a regimen of estradiol and progesterone that mimics the preventive effect of pregnancy against mammary cancer.
Swanson, S. M., Whitaker, L. M., Stockard, C. R., Myers, R. B., Oelschlager, D. K., Grizzle, W. E., Juliana, M. M., & Grubbs, C. J. (1997) · PubMed · Cited by 29 · see citing works
Relation between Histological Intensity of Transforming Growth Factor-.BETA. Isoforms in Human Osteosarcoma and the Rate of Lung Metastasis.
Yang, R., Wu, C., Lin, K.-H., Hong, R., Liu, T., & Lin, K. (1998) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.184.133 · Cited by 28 · see citing works
Transcriptional deregulation of VEGF, FGF2, TGF-β1, 2, 3 and cognate receptors in breast tumorigenesis
Soufla, G., Porichis, F., Sourvinos, G., Vassilaros, S. D., & Spandidos, D. A. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.022 · Cited by 28 · see citing works
PDGF-A, PDGF-Rβ, TGFβ3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmoplasia: an immunohistochemical study
Zhang, P. J., Goldblum, J. R., Pawel, B., Pasha, T. L., Fisher, C., & Barr, F. G. (2004) · Modern Pathology · doi:10.1038/modpathol.3800264 · Cited by 26 · see citing works
Expression of TGF‐β isoforms and their receptors during mineralized nodule formation by rat periodontal ligament cells in vitro
Chien, H., Lin, W., & Cho, M. (1999) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1999.tb02258.x · Cited by 24 · see citing works
Transforming growth factor-β3 is expressed in nondividing basal epithelial cells in normal human prostate and benign prostatic hyperplasia, and is no longer detectable in prostate carcinoma
Djonov, V., Ball, R. K., Graf, S., Mottaz, A. E., Arnold, A., Flanders, K., Studer, U. E., & Merz, V. W. (1997) · The Prostate · doi:10.1002/(sici)1097-0045(19970501)31:2 · Cited by 22 · see citing works
Transforming Growth Factor Beta 1 Serum Levels in Patients with Preinvasive and Invasive Lesions of the Breast
Lebrecht, A., Grimm, C., Euller, G., Ludwig, E., Ulbrich, E. J., Lantzsch, T., Hefler, L., & Koelbl, H. (2004) · The International Journal of Biological Markers · doi:10.5301/jbm.2008.2143 · Cited by 21 · see citing works
TGFβ Signaling Pathways and Human Diseases
Padgett, R. W. (1999) · Cancer and Metastasis Reviews · doi:10.1023/a:1006325408261 · Cited by 19 · see citing works
Differential effects of transforming growth factor-βs and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes
Ren, R. F., Lah, J. J., Diehlmann, A., Kim, E. S., Hawver, D. B., Levey, A. I., Beyreuther, K. T., & Flanders, K. C. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00215-8 · Cited by 18 · see citing works
Letter to the Editor: Sequence-specific 1H and 15N assignment and secondary structure of transforming growth factor β3
Bocharov, E. V., Blommers, M. J. J., Kuhla, J., Arvinte, T., Bürgi, R., & Arseniev, A. S. (2000) · Journal of Biomolecular NMR · doi:10.1023/a:1008315600134 · Cited by 16 · see citing works
Expression of Transforming Growth Factor β Isoforms and Their Receptors in Malignant Fibrous Histiocytoma of Soft Tissues
Yamamoto, T., Akisue, T., Marui, T., Fujita, I., Matsumoto, K., Hitora, T., Kawamoto, T., Nagira, K., Nakatani, T., & Kurosaka, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0770-03 · Cited by 16 · see citing works
Structure of D -ribulose 5-phosphate 3-epimerase fromSynechocystisto 1.6 Å resolution
Wise, E. L., Akana, J., Gerlt, J. A., & Rayment, I. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904015896 · Cited by 14 · see citing works
Transforming growth factor-beta s in mammary tumorigenesis: promoters or antipromoters?
Wakefield, L. M., Letterio, J. J., Geiser, A. G., Flanders, K. C., O’Shaughnessy, J., Roberts, A. B., & Sporn, M. B. (1995) · PubMed · Cited by 14 · see citing works
Self-citation
The effect of TGF-β1 on cell proliferation and proteoglycan production in human melanoma cells depends on the degree of cell differentiation
Heredia, A., Villena, J., Romarı́s, M., Molist, A., & Bassols, A. (1996) · Cancer Letters · doi:10.1016/s0304-3835(96)04402-3 · Cited by 12 · see citing works
Plasma CD105, TGFbeta-1, TGFbeta-3 and the ligand/receptor complexes in children with acute lymphoblastic leukaemia.
Al-Mowallad, A. F., Carr, T. F., Al-Qouzi, A., Li, C., Byers, R. J., & Kumar, S. (2006) · PubMed · Cited by 7 · see citing works
Overexpression of transforming growth factor‐β3 immunohistochemical staining in extramammary Paget's disease, but downregulated expression in Bowen's disease
Kawakami, T., Soma, Y., Mizoguchi, M., & Saito, R. (2001) · International Journal of Dermatology · doi:10.1046/j.1365-4362.2001.01026.x · Cited by 6 · see citing works
Transforming growth factor-beta2 and beta3 expression in carcinoma of the prostate.
Parada, D., Arciniegas, E., Moreira, O. E., & Trujillo, E. (2004) · PubMed · Cited by 5 · see citing works
Cellular senescence and cancer
(1999) · doi:10.1002/(sici)1096-9896(199901)187:1

Flagged first, then by citations

12 of the 176 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

[64]MacDougall JR, Kobayashi H, Kerbel RS. Responsiveness of normal dysplastic melanocytes and melanoma cells from different lesional stages of disease progression to the growth inhibitory effects of TGF-β. Mol Cell Different 1993; 1: 21– 40.

Sorted by citations

Long non-coding RNAs and cancer: a new frontier of translational research?
Spizzo, R., Almeida, M. I., Colombatti, A., & Călin, G. A. (2012) · Oncogene · doi:10.1038/onc.2011.621 · Cited by 1,004 · see citing works
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works
The Role of Cytokines in Breast Cancer Development and Progression
Esquivel‐Velázquez, M., Ostoa‐Saloma, P., Arreola, M. I. P., Castro, K. E. N., Castro, J. I., & Morales‐Montor, J. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0026 · Cited by 495 · see citing works
Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring
Finnson, K. W., McLean, S., Guglielmo, G. M. D., & Philip, A. (2013) · Advances in Wound Care · doi:10.1089/wound.2013.0429 · Cited by 302 · see citing works
Promiscuity and specificity in BMP receptor activation
Mueller, T. D., & Nickel, J. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.02.043 · Cited by 285 · see citing works
Role of Transforming Growth Factor Beta in Corneal Function, Biology and Pathology
Tandon, A., Tovey, J. C. K., Sharma, A., Gupta, R., & Mohan, R. R. (2010) · Current Molecular Medicine · doi:10.2174/1566524011009060565 · Cited by 245 · see citing works
Targeting TGF-β Signaling for Therapeutic GainPreprint
Akhurst, R. J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022301 · Cited by 243 · see citing works
Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration
Gilbert, R. W. D., Vickaryous, M. K., & Viloria‐Petit, A. (2016) · Journal of Developmental Biology · doi:10.3390/jdb4020021 · Cited by 193 · see citing works
Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily
Radaev, S., Zou, Z., Huang, T., Lafer, E. M., Hinck, A. P., & Sun, P. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.079921 · Cited by 165 · see citing works
NKT Cell Networks in the Regulation of Tumor Immunity
Robertson, F. C., Berzofsky, J. A., & Terabe, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00543 · Cited by 124 · see citing works
Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue
Petrus, P., Mejhert, N., Corrales, P., Lecoutre, S., Li, Q., Maldonado, E., Kulyté, A., López, Y., Campbell, M., Acosta, J. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.069 · Cited by 123 · see citing works
TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis
Qin, X., Yan, M., Zhang, J., Wang, X., Shen, Z., Lv, Z., Li, Z., Wei, W., & Chen, W. (2016) · Scientific Reports · doi:10.1038/srep20587 · Cited by 117 · see citing works
Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion
Sundqvist, A., Zieba, A., Vasilaki, E., Hidalgo, C. H., Söderberg, O., Koinuma, D., Miyazono, K., Ch, H., Landegren, U. D., ten Dijke, P., et al. (2012) · Oncogene · doi:10.1038/onc.2012.370 · Cited by 107 · see citing works
Revisiting the regulatory roles of the TGF-β family of cytokines
Fujio, K., Komai, T., Inoue, M., Morita, K., Okamura, T., & Yamamoto, K. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.07.007 · Cited by 106 · see citing works
Role of TGF-β in metastatic colon cancer: it is finally time for targeted therapy
Villalba-Esparza, M., Evans, S. R., Vidal‐Vanaclocha, F., & Calvo, A. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2633-9 · Cited by 103 · see citing works
Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis
Qi, H., Xin, L.-Y., Xu, X., Ji, X., & Fan, L. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-22 · Cited by 92 · see citing works
Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy
Terabe, M., Robertson, F. C., Clark, K. T., Ravin, E. D., Bloom, A. C., Venzon, D. J., Kato, S., Mirza, A. M., & Berzofsky, J. A. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1308616 · Cited by 89 · see citing works
Integrated network analysis and machine learning approach for the identification of key genes of triple‐negative breast cancer
Naorem, L. D., Muthaiyan, M., & Venkatesan, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27903 · Cited by 70 · see citing works
Colostrum and Mature Human Milk of Women from London, Moscow, and Verona: Determinants of Immune Composition
Munblit, D., Сергеевна, Т. М., Peroni, D. G., Colicino, S., Chow, L., Dissanayeke, S. R., Abrol, P., Sheth, S., Pampura, A. N., Boner, A. L., et al. (2016) · Nutrients · doi:10.3390/nu8110695 · Cited by 69 · see citing works
TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy
Merčnik, M. H., Schliefsteiner, C., Sánchez‐Duffhues, G., & Wadsack, C. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae007 · Cited by 72 · see citing works
Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production
Morita, K., Okamura, T., Inoue, M., Komai, T., Teruya, S., Iwasaki, Y., Sumitomo, S., Shoda, H., Yamamoto, K., & Fujio, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611286114 · Cited by 67 · see citing works
Generation of mice with a conditional allele for the transforming growth factor beta3 gene
Doetschman, T., Georgieva, T. G., Li, H., Reed, T. D., Grisham, C., Friel, J., Estabrook, M. A., Gard, C., Sanford, L. P., & Azhar, M. (2011) · genesis · doi:10.1002/dvg.20789 · Cited by 64 · see citing works
S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI Imaging
Nipp, M., Elsner, M., Balluff, B., Meding, S., Sarioglu, H., Ueffing, M., Rauser, S., Unger, K., Höfler, H., Walch, A. K., et al. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0815-6 · Cited by 63 · see citing works
Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma
Seystahl, K., Papachristodoulou, A., Burghardt, I., Schneider, H., Hasenbach, K., Janicot, M., Roth, P., & Weller, M. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0465 · Cited by 60 · see citing works
Transforming Growth Factor-β1 and -β2 in Gastric Precancer and Cancer and Roles in Tumor-Cell Interactions with Peripheral Blood Mononuclear Cells In Vitro
Ma, G., Miao, Q., Zeng, X., Luo, T., Ma, L., Liu, Y., Lian, J., Gao, H., & Chen, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054249 · Cited by 59 · see citing works
Recent Advances in Understanding Mechanisms of TGF Beta Signaling and Its Role in Glioma Pathogenesis
Kaminska, B., & Cyranowski, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-30651-9_9 · Cited by 54 · see citing works
Immunological Differences Between Immune-Rich Estrogen Receptor–Positive and Immune-Rich Triple-Negative Breast Cancers
O’Meara, T. A., Marczyk, M., Qing, T., Yaghoobi, V., Blenman, K., Cole, K. S., Pelekanou, V., Rimm, D. L., & Pusztai, L. (2020) · JCO Precision Oncology · doi:10.1200/po.19.00350 · Cited by 53 · see citing works
Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective
Danielpour, D. (2024) · Pharmaceuticals · doi:10.3390/ph17040533 · Cited by 52 · see citing works
Culture supernatants of cervical cancer cells induce an M2 phenotypic profile in THP-1 macrophages
Pedraza‐Brindis, E. J., Sánchez-Reyes, K., Hernández‐Flores, G., Bravo‐Cuéllar, A., Jave‐Suárez, L. F., Aguilar‐Lemarroy, A., Gómez-Lomelí, P., López-López, B. A., & Ortiz‐Lazareno, P. C. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.07.001 · Cited by 49 · see citing works
Skin Cancer Arising in Scars: A Systematic Review
Wallingford, S. C., Olsen, C. M., Plasmeijer, E. I., & Green, A. C. (2011) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2011.02060.x · Cited by 44 · see citing works
Expression of TGFβ3 and its effects on migratory and invasive behavior of prostate cancer cells: involvement of PI3-kinase/AKT signaling pathway
Walker, L., Millena, A. C., Strong, N., & Khan, S. A. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-012-9494-0 · Cited by 44 · see citing works
Transforming Growth Factor-β and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment
van Dorst, D. C. H., Wagenaar, N. P. V.-D., van der Pluijm, I., Roos‐Hesselink, J. W., Essers, J., & Danser, A. H. J. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07116-4 · Cited by 43 · see citing works
Transforming Growth Factor-β3 (TGF-β3) Knock-in Ameliorates Inflammation Due to TGF-β1 Deficiency While Promoting Glucose Tolerance
Hall, B. E., Wankhade, U. D., Konkel, J. E., Cherukuri, K. S., Nagineni, C. N., Flanders, K. C., Arany, P. R., Chen, W., Rane, S. G., & Kulkarni, A. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.480764 · Cited by 42 · see citing works
Baicalin inhibits human osteosarcoma cells invasion, metastasis, and anoikis resistance by suppressing the transforming growth factor-β1-induced epithelial-to-mesenchymal transition
Wang, Y., Wang, H., Zhou, R., Zhong, W., Lu, S., Ma, Z., & Chai, Y. (2017) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000495 · Cited by 40 · see citing works
Involvement of miR‐140‐3p in Wnt3a and TGF β3 signaling pathways during osteoblast differentiation in MC 3T3‐E1 cells
Fushimi, S., Nohno, T., Nagatsuka, H., & Katsuyama, H. (2018) · Genes to Cells · doi:10.1111/gtc.12591 · Cited by 39 · see citing works
Chimaphilin inhibits human osteosarcoma cell invasion and metastasis through suppressing the TGF-β1-induced epithelial-to-mesenchymal transition markers via PI-3K/Akt, ERK1/2, and Smad signaling pathways
Dong, F., Liu, T., Jin, H., & Wang, W. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0522 · Cited by 37 · see citing works
Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder
Liu, F., Li, Y., Ying, D., Qiu, S., He, Y., Li, M., Liu, Y., Zhang, Y., Hu, Y., Hu, Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00412-3 · Cited by 36 · see citing works
TGFβ isoforms and receptors mRNA expression in breast tumours: prognostic value and clinical implications
Chen, C., Zhao, K., Masci, P. P., Lakhani, S. R., Antonsson, A., Simpson, P. T., & Vitetta, L. (2015) · BMC Cancer · doi:10.1186/s12885-015-1993-3 · Cited by 33 · see citing works
Interleukin-1 beta and transforming growth factor-beta 3 cooperate to activate matrix metalloproteinase expression and invasiveness in A549 lung adenocarcinoma cells
Petrella, B. L., Armstrong, D. A., & Vincenti, M. P. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.07.009 · Cited by 33 · see citing works
Differential role of PTEN in transforming growth factor β (TGF‐β) effects on proliferation and migration in prostate cancer cells
Kimbrough-Allah, M., Millena, A. C., & Khan, S. A. (2018) · The Prostate · doi:10.1002/pros.23482 · Cited by 29 · see citing works
Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
Jakopović, B., Oršolić, N., & Jakopovich, I. (2021) · Molecules · doi:10.3390/molecules26216708 · Cited by 28 · see citing works
Advances in Immunotherapy and the TGF-β Resistance Pathway in Metastatic Bladder Cancer
Benjamin, D. J., & Lyou, Y. (2021) · Cancers · doi:10.3390/cancers13225724 · Cited by 26 · see citing works
A new TGF‐β3 controlled‐released chitosan scaffold for tissue engineering synovial sheath
Jiang, K., Wang, Z., Du, Q., Jiang, Y., Wang, A., & Xiong, Y. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34742 · Cited by 26 · see citing works
BMP2 as a promising anticancer approach: functions and molecular mechanisms
Li, T., Lai, Y.-W., Han, X., Niu, X., & Zhang, P.-X. (2022) · Investigational New Drugs · doi:10.1007/s10637-022-01298-4 · Cited by 23 · see citing works
Transforming growth factor‐β enhances invasion and metastasis in Ras‐transfected human malignant epidermal keratinocytes
Davies, M., Prime, S. S., Eveson, J. W., Price, N., Ganapathy, A., d'Mello, A., & Paterson, I. C. (2012) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00806.x · Cited by 23 · see citing works
The Role of TGF-β3 in Radiation Response
Hanson, I., Pitman, K. E., & Edin, N. F. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087614 · Cited by 22 · see citing works
TGF-β1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells
Chen, Q., Li, Y., Shao, Y., Yu-hua, Z., Ren, W., Liu, R., Zhou, L., Hu, X., Huang, M., He, F., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3875 · Cited by 21 · see citing works
Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
Poulet, S., Dai, M., Wang, N., Yan, G., Boudreault, J., Daliah, G., Guillevin, A., Nguyen, H., Galal, S., Ali, S., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02029-4 · Cited by 22 · see citing works
Improving knowledge on the activation of bone marrow fibroblasts in MGUS and MM disease through the automatic extraction of genes via a nonnegative matrix factorization approach on gene expression profiles
Boccarelli, A., Esposito, F., Coluccia, M., Frassanito, M. A., Vacca, A., & Buono, N. D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1589-1 · Cited by 19 · see citing works
Ethnic differences in TGFβ-signaling pathway may contribute to prostate cancer health disparity
Elliott, B., Zackery, D. L., Eaton, V., Jones, R. T., Abebe, F., Ragin, C. C. R., & Khan, S. A. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy020 · Cited by 19 · see citing works
Transforming growth factor-β gene silencing using adenovirus expressing TGF-β1 or TGF-β2 shRNA
Oh, S., Kim, E., Kang, D., Kim, M., Kim, J.-H., & Song, J. J. (2013) · Cancer Gene Therapy · doi:10.1038/cgt.2012.90 · Cited by 18 · see citing works
TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)
Scherer, S. D., Bauer, J., Schmaus, A., Neumaier, C., Herskind, C., Veldwijk, M. R., Wenz, F. K., & Sleeman, J. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162221 · Cited by 17 · see citing works
Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development
Sarper, S. E., Kurosaka, H., Inubushi, T., Minagi, H. O., Kuremoto, K.-I., Sakai, T., Taniuchi, I., & Yamashiro, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-29681-3 · Cited by 16 · see citing works
Mechanisms of BMP–Receptor Interaction and Activation
Mueller, T. D. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2015.06.003 · Cited by 15 · see citing works
Therapeutic potential of regulatory cytokines that target B cells
Fujio, K., Okamura, T., Sumitomo, S., & Yamamoto, K. (2015) · International Immunology · doi:10.1093/intimm/dxv069 · Cited by 15 · see citing works
A novel multi-stage feature selection method for microarray expression data analysis
Du, W., Sun, Y., Wang, Y., Cao, Z., Zhang, C., & Liang, Y. (2012) · International Journal of Data Mining and Bioinformatics · doi:10.1504/ijdmb.2013.050977 · Cited by 14 · see citing works
EIF5A2 Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Growth by Modulating TGF- Signals
Hao, F., Zhu, Q., Lu, L., Sun, S., Huang, Y., Zhang, J., Liu, Z., Miao, Y., Jiao, X., & Chen, D. (2020) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504020x15834065061807 · Cited by 14 · see citing works
Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis
Boudreault, J., Wang, N., Ghozlan, M., & Lebrun, J. J. (2024) · Cancers · doi:10.3390/cancers16010224 · Cited by 13 · see citing works
Anti-TGF-β1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model
Takahashi, M., Hashimoto, Y., & Nakamura, Y. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.06.001 · Cited by 13 · see citing works
Tumor-educated Gr1+CD11b+ cells drive breast cancer metastasis via OSM/IL-6/JAK–induced cancer cell plasticity
Peyvandi, S., Bulliard, M., Yilmaz, A., Kauzlaric, A., Marcone, R., Haerri, L., Coquoz, O., Huang, Y.-T., Duffey, N., Gafner, L., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci166847 · Cited by 12 · see citing works
Development and experimental validation of an M2 macrophage and platelet‐associated gene signature to predict prognosis and immunotherapy sensitivity in bladder cancer
Muhuitijiang, B., Zhou, J., Zhou, R., Zhang, Z., Yan, G., Zheng, Z., Zeng, X., Zhu, Y., Wu, H., Gao, R., et al. (2024) · Cancer Science · doi:10.1111/cas.16113 · Cited by 12 · see citing works
Phytochemical analysis and in vitro anti-inflammatory, anticancer activities of Marrubium lutescens on melanoma cancer cell line and molecular docking studies
Sarıkürkçü, C., Erdoğmuş, S. F., & Yazar, T. (2024) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2024.100907 · Cited by 12 · see citing works
Association of TGF-β2 levels in breast milk with severity of breast biopsy diagnosis
Yang, H., Schneider, S. S., Chisholm, C., Browne, E. P., Mahmood, S., Gierach, G. L., Lenington, S., Anderton, D. L., Sherman, M. E., & Arcaro, K. F. (2015) · Cancer Causes & Control · doi:10.1007/s10552-014-0498-8 · Cited by 11 · see citing works
Residues of Alpha Helix H3 Determine Distinctive Features of Transforming Growth Factor β3
Nayeem, S. M., Oteri, F., Baaden, M., & Deep, S. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.7b01867 · Cited by 11 · see citing works
Proteomics reveals the function reverse of MPSSS‐treated prostate cancer‐associated fibroblasts to suppress PC‐3 cell viability via the FoxO pathway
Zhang, T., Chen, X., Sun, L., Guo, X., Cai, T., Wang, J., Zeng, Y., Ma, J., Ding, X. D., Xie, Z., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.3825 · Cited by 9 · see citing works
HIPPO signaling-related signature for predicting prognosis and therapeutic response in gastric cancer
Jiang, R., Wang, J., Liang, J., Lin, D., Mao, Q., Cheng, S., Huang, S.-J., Tong, S., Lyu, Y., Wei, R., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1096055 · Cited by 9 · see citing works
Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers
Meaburn, K. J., & Misteli, T. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01029 · Cited by 9 · see citing works
Targeted Mutations of Genes Reveal Important Roles in Palatal Development in Mice
Ma, L., Shi, B., & Zheng, Q. (2013) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e318295dcb8 · Cited by 8 · see citing works
Possible Inflammatory Origin of Endometrial Polyps
L, R., Cicinelli, E., & T, L. (2018) · Archives of reproductive medicine and sexual health · doi:10.22259/2639-1791.0102003 · Cited by 7 · see citing works
High Intra-Tumor Transforming Growth Factor Beta 2 Level as a Predictor of Poor Treatment Outcomes in Pediatric Diffuse Intrinsic Pontine Glioma
Uckun, F. M., Qazi, S., & Trieu, V. N. (2023) · Cancers · doi:10.3390/cancers15061676 · Cited by 8 · see citing works
TGF-β3 reduces apoptosis in ischemia-induced adipose-derived stem cells by enhancing DNA repair
Wu, F., Ye, H., Lin, J., Xu, Y., Zhang, Z., Xiong, H., Laing, M., Zhen, Y., & Chen, S. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5980 · Cited by 7 · see citing works
TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model
Hanson, I., Juvkam, I. S., Zlygosteva, O., Søland, T. M., Galtung, H. K., Malinen, E., & Edin, N. F. J. (2024) · International Journal of Radiation Biology · doi:10.1080/09553002.2024.2324476 · Cited by 6 · see citing works
Overcoming resistance to PD-1 inhibitors: the synergistic anti-tumor effect with inflammatory factors
Yan, H., Wang, Y., Zhu, M., Sun, D., Li, H., & Chen, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115555 · Cited by 5 · see citing works
Cytokines and cancer-associated fibroblasts
Hu, Y., Liang, J.-J., Duan, L., Zhu, J., Shan, G., Cheng, T., Wu, Y., Tan, L., & Zhan, C. (2026) · Journal of Hematology & Oncology · doi:10.1186/s13045-026-01801-x · Cited by 5 · see citing works
Transforming growth factor-β (TGF-β) signaling pathway-related genes in predicting the prognosis of colon cancer and guiding immunotherapy
Chen, J., Ji, C., Liu, S., Wang, J., Wang, C., Pan, J., Qiao, J., Yu, L., Cai, M., & Ma, J. (2023) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2023.12.002 · Cited by 5 · see citing works
TGFβ3 regulates adipogenesis of bovine subcutaneous preadipocytes via typical Smad and atypical MAPK signaling pathways
Yang, L., Wang, H., Hao, W., Li, T., Fang, H., Bai, H., Yan, P., & Wei, S. (2022) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2022.11.001 · Cited by 4 · see citing works
RGD Density on Tadpole Nanostructures Regulates Cancer Stem Cell Proliferation and Stemness
Zhang, D., Sun, B. F., Wang, J., Chen, S. R., Bobrin, V. A., Gu, Y., Ng, C. K., Gu, W., & Monteiro, M. J. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00645 · Cited by 4 · see citing works
Interplay of Transforming Growth Factor-Beta 1 and 3 in the Pathogenesis of Oral Submucous Fibrosis and Its Malignant Transformation: An Immunohistochemical Study
Bansal, S. P., Pereira, T., Desai, R. S., Jena, A., Bobade, P. P., & Patil, M. (2023) · Cureus · doi:10.7759/cureus.42412 · Cited by 4 · see citing works
Advances in Biopharmaceutical Agents and Growth Factors for Wound Healing and Scarring
Lali, F. V., Hewings-Martin, Y., & Metcalfe, A. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801654-1.00017-6 · Cited by 4 · see citing works
E2F1 K117 methylation by SETD6 disrupts BRD4–E2F1 binding and modulates E2F1 chromatin binding and gene regulation in prostate cancer cells
Ulu, G. T., Kublanovsky, M., Shalev, R., Biton, T. E., Feldman, M. W., Murr, S., Brockmeyer, J., Dorscht, F., Weirich, S., Levy, D., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkaf1513 · Cited by 8 · see citing works
Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms
Jakopović, B., Oršolić, N., Pavelić, S. K., & Jakopovich, I. (2023) · Springer eBooks · doi:10.1007/978-981-19-9550-7_11 · Cited by 3 · see citing works
The potential role of transforming growth factor beta family ligand interactions in prostate cancer
Croxford, K. P., Reader, K. L., & Nicholson, H. D. (2017) · AIMS molecular science · doi:10.3934/molsci.2017.1.41 · Cited by 3 · see citing works
Comparative Effects of the Preventive Effect of Pregnancy, Steroidal Hormones, and hCG in the Transcriptomic Profile of the Rat Mammary Gland
Russo, J., & Russo, I. H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4884-6_3 · Cited by 3 · see citing works
TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy
Teng, Q., Wang, N., Lei, H., Tong, T., Guan, Y., Huang, M., Cao, F., Xu, B., Yang, J., Huo, Y., et al. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04103-2 · Cited by 2 · see citing works
Immunoinformatic analysis of role of tumor microenvironment constituents secreted ligands in breast cancer progression, metastasis, prognosis, survival and development of effective tumor microenvironment directed therapeutic strategy
Mondal, P., Mahanti, K., & Bhattacharyya, S. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100017 · Cited by 2 · see citing works
Identification of Transforming Growth Factor-β3 Signaling by Compressive Force in MC3T3-E1 Cells Reactions
Togawa, M., Nakajima, A., Fukumashi, N., & Kawato, T. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01783-6 · Cited by 2 · see citing works
Determinants of colostrum and breast milk immune composition and consequences for infant health
Munblit, D. (2015) · doi:10.25560/42364 · Cited by 2 · see citing works
Interaction of TGFβ3 ligand with its receptors type II (TβRII) and type I (TβRI): A unique mechanism of protein-protein association
Dawn, A., Khatri, K. S., Karmakar, S., & Deep, S. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140485 · Cited by 2 · see citing works
Direct early growth response-1 knockdown decreases melanoma viability independent of mitogen-activated extracellular signal-related kinase inhibition
Miley, D. R., Andrews-Pfannkoch, C. M., Pulido, J. S., Erickson, S. A., Vile, R. G., Fautsch, M. P., Marmorstein, A. D., & Dalvin, L. A. (2023) · Melanoma Research · doi:10.1097/cmr.0000000000000921 · Cited by 2 · see citing works
Function of Transforming Growth Factor β2 and β3 in Palatogenesis
Aoki, M., Nakajima, A., Fukumashi, N., Okuma, R., Motoyoshi, M., & Shuler, C. F. (2025) · Cells Tissues Organs · doi:10.1159/000544097 · Cited by 1 · see citing works
Exploring the Anticancer, Anti‐Inflammatory, and Antibiofilm Efficacy of Endemic Stachys longiflora : Insights into the Phytochemical Composition
GÜLDAR, E., Erdoğmuş, S. F., & Sarıkürkçü, C. (2025) · ChemistryOpen · doi:10.1002/open.202500146 · Cited by 1 · see citing works
In Vitro and In Silico Evaluation of Sideritis Pisidica : Insights into Biological Potential in Melanoma Cancer Cells
Erdoğmuş, S. F., KOKENER, N., Istıflı, E. S., & Sarıkürkçü, C. (2025) · ChemistrySelect · doi:10.1002/slct.202503368 · Cited by 1 · see citing works
Influence of Sex and Diet on the Gastrointestinal Tract in a Mice Model with Partial Deficiency for TGF-β3
Gallego-Barceló, P., Bagüés, A., Escasany, E., López‐Tofiño, Y., Márquez, A., Medina‐Gómez, G., Uranga, J. A., & Abalo, R. (2020) · International Electronic Conference on Nutrients (IECN) · doi:10.3390/iecn2020-06983 · Cited by 1 · see citing works
Scar-free wound healing and regeneration in the leopard gecko (Eublepharis macularius)
Delorme, S. (2011) · The Atrium (University of Guelph) · Cited by 1 · see citing works
Cytotoxicity of ascorbate to cancer cells: mathematical modelling, mechanisms and clinical implications
Chen, C. (2015) · The University of Queensland · doi:10.14264/uql.2015.292 · Cited by 1 · see citing works
Application of morphometry, static DNA ploidy analysis, and steroid receptor expression in diagnosis and prognosis of Libyan breast cancer
Abdalla, F. (2012) · UTUPub (University of Turku) · Cited by 1 · see citing works
Epithelial to mesenchymal transition in the metastatic progression of gastroenteropancreatic neuroendocrine tumours
Mok, S. (2015) · Scholarship@Western (Western University)
STUDIO DEL POSSIBILE RUOLO DEL COMPLESSO POLYCOMB NEL DETERMINARE LA SCHISI DEL LABBRO E DEL PALATO
Tesi, T. D. (2015)
Faculty Opinions recommendation of Signalling by transforming growth factor beta isoforms in wound healing and tissue regeneration.
Pihlajaniemi, T. A., & Heljäsvaara, R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731487222.793560513
Comparison of thewound healing effects of vascular endothelial growth factor a (VEGF-A) and transforming growth factor beta 3 (TGF-β3) on gingival cells
Yelliand, S., Yıldırım, A., Tayhan, S. E., Bilgin, S., & Gökçe, İ. (2023) · International Journal of Chemistry and Technology · doi:10.32571/ijct.1249472

Transforming Growth Factor-βs and Mammary Gland Involution; Functional Roles and Implications for Cancer Progression
Flanders, K. C., & Wakefield, L. M. (2009) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-009-9122-z · Cited by 71 · see citing works
Self-citation
Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
Huang, J. J. (2019)
TGF-? isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis
Gold, L. I., Jussila, T., Fusenig, N. E., & Stenb�ck, F. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200004)190:5 · Cited by 57 · see citing works
TGF beta signalling and its role in tumour pathogenesis.
Kamińska, B., Wesolowska, A. M., & Danilkiewicz, M. (2005) · Acta Biochimica Polonica · doi:10.18388/abp.2005_3446 · Cited by 186 · see citing works
Transforming growth factor-β in cancer and metastasis
Jakowlew, S. B. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9006-2 · Cited by 519 · see citing works

Authors: Laverty, H. G., Wakefield, L. M., Occleston, N. L., O’Kane, S., & Ferguson, M. W. J.
Affiliations: Renovo (United Kingdom) (GB)
National Institutes of Health (US)
Corresponding author: Ferguson, M.W.J.
ORCID: Wakefield, L.M.
Ferguson, M.W.J.
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2009-08
Volume: 20
Issue: 4
Pages: 305-317
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2009.07.002
PMC: PMC7294566
OpenAlex: W2025475845
Cited by: 110
References: 176
Citations by year: 2026: 7 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 9
FWCI: 0.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (Z01BC010881)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: TGF-beta3, tumourigenesis, tumor progression, TGF-beta isoforms, TGF-β1, growth factor therapy, tumor suppression, scar tissue, breast cancer, oral mucosa, gastric mucosa
MeSH terms: Amino Acid Sequence, Animals, Humans, Models, Molecular, Molecular Conformation, Molecular Sequence Data, Neoplasms, Sequence Homology, Amino Acid, Protein Isoforms, Transforming Growth Factor beta3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TGF-β3 and cancer: A review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks