The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions
Abstract
Two homologous genes, lin-12 and glp-1, encode transmembrane proteins required for regulatory cell interactions during C. elegans development. Based on their single mutant phenotypes, each gene has been thought to govern a distinct set of cell fates. We show here that lin-12 and glp-1 are functionally redundant during embryogenesis: Unlike either single mutant, the lin-12 glp-1 double mutant dies soon after hatching. Numerous cellular defects can be observed in these Lag (for lin-12 and glp-1) double mutants. Furthermore, we have identified two genes, lag-1 and lag-2, that appear to be required for both lin-12 and glp-1 -mediated cell interactions. Strong loss-of-function lag. mutants are phenotypically indistinguishable from the lin-12 glp-1 double; weak lag mutants have phenotypes typical of lin-12 and glp-1 single mutants. We speculate that the lin-12 and glp-1 proteins are biochemically interchangeable and that their divergent roles in development may rely largely on differences in gene expression.
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Citations
Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Cited by
Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310
Thinking about genetic redundancy
Thomas, J. H. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90140-d · Cited by 239
C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence
Singh, K., Chao, M. Y., Somers, G. A., Komatsu, H., Corkins, M. E., Larkins-Ford, J., Tucey, T., Dionne, H. M., Walsh, M. B., Beaumont, E. K., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.04.010 · Cited by 137
Metadata
- Authors
- Lambie, E. J., & Kimble, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-05-01
- Volume
- 112
- Issue
- 1
- Pages
- 231-240
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2154047394
- Cited by
- 253
- References
- 1
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lambie, E. J., & Kimble, J. (1991). Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions. Development. https://doi.org/10.1242/dev.112.1.231
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