The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage
Abstract
Using in situ hybridization, we have visualized cells in the rat central nervous system (CNS) that contain mRNA encoding the platelet-derived growth factor alpha receptor (PDGF-αR). After embryonic day 16 (E16), PDGF-αR mRNA appears to be expressed by a subset of glial cells, but not by neurons. The temporal and spatial distribution of PDGF-αR+ cells, together with 125I-PDGF binding studies on subsets of glial cells in vitro, suggests that PDGF-αR may be expressed predominantly, or exclusively, by cells of the oligodendrocyte-type-2 astrocyte (O-2A) lineage. This conclusion is supported by the fact that the numbers of PDGF-αR+ cells in developing and adult optic nerves correlate well with independent estimates of the number of O-2A progenitor cells in the nerve at equivalent ages. Small numbers of PDGF-αR+ cells are present in the brain at E16, at which time they are found outside the subventricular germinal zones, suggesting that these cells do not express PDGF-αR until after, or shortly before they start to migrate away from the subventricular layer towards their final destinations. Reduced numbers of PDGF-αR+ cells persist in the adult CNS. PDGF-αR is also expressed strongly in the meningeal membranes and choroid plexus, and in the inner limiting membrane of the retina.
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Cites
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Self-citationNoble, M., Murray, K., Stroobant, P., Waterfield, M. D., & Riddle, P. (1988) · Nature · doi:10.1038/333560a0 · Cited by 830
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819
Cited by
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Self-citationPDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Self-citationOligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
Self-citationPolydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
Regulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843
Metadata
- Authors
- Pringle, N. P., Mudhar, H. S., Collarini, E. J., & Richardson, W. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-06-01
- Volume
- 115
- Issue
- 2
- Pages
- 535-551
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2245482469
- Cited by
- 443
- References
- 3
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. https://app.cochat.ai/papers/10.1242/dev.115.2.535
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- Pringle, N. P., Mudhar, H. S., Collarini, E. J., & Richardson, W. D. (1992). PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development. https://doi.org/10.1242/dev.115.2.535
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
