Regulation of innate immune responses in the brain

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

Untitled work

Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

The inflammatory response in stroke.

Wang, Q., Tang, X.-N., & Yenari, M. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.014 · Cited by 1,195 · see citing works

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Zhang, S., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P. J., Segal, D. M., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., et al. (2007) · Science · doi:10.1126/science.1139522 · Cited by 1,165 · see citing works

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

Wang, T., Town, T., Alexopoulou, L., Anderson, J. F., Fikrig, E., & Flavell, R. A. (2004) · Nature Medicine · doi:10.1038/nm1140 · Cited by 1,155 · see citing works

Cytokines and acute neurodegeneration

Allan, S. M., & Rothwell, N. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094583 · Cited by 1,126 · see citing works

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089 · see citing works

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.

Lu, Q. R., Sun, T., Zhu, Z.-M., Ma, N., García, M., Stiles, C., & Rowitch, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,064 · see citing works

The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059 · cited 1× · see citing works

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,059 · see citing works

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052 · see citing works

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

Ray, S., Britschgi, M., Herbert, C., Takeda-Uchimura, Y., Boxer, A., Blennow, K., Friedman, L. F., Galasko, D. R., Jutel, M., Karydas, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1653 · Cited by 1,048 · see citing works

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works

Interleukin-1 and neuronal injury

Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992 · see citing works

Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works

Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain

Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874 · see citing works

TLR signaling tailors innate immune responses in human microglia and astrocytes

Jack, C. S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., McCrea, E., Shapiro, A., & Antel, J. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4320 · Cited by 734 · see citing works

Innate immunity: the missing link in neuroprotection and neurodegeneration?

Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 698 · see citing works

Depletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury

Popovich, P. G., Guan, Z., Wei, P. Y., Huitinga, I., van Rooijen, N., & Stokes, B. T. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7118 · Cited by 692 · see citing works

The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

Lehnardt, S., Lachance, C., Patrizi, S., Lefebvre, S., Follett, P. L., Jensen, F. E., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02478.2002 · Cited by 684 · see citing works

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1356 · Cited by 637 · see citing works

The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.

Zhou, Q., Choi, G. B., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00414-7 · Cited by 625 · see citing works

Toll-like receptors modulate adult hippocampal neurogenesis

Rolls, A., Shechter, R., London, A., Ziv, Y., Ronen, A., Levy, R., & Schwartz, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1629 · Cited by 620 · see citing works

Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

Yin, Y., Henzl, M. T., Lorber, B., Nakazawa, T., Thomas, T. T., Jiang, F., Langer, R., & Benowitz, L. I. (2006) · Nature Neuroscience · doi:10.1038/nn1701 · Cited by 516 · see citing works

γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

Sisodia, S. S., & St George-Hyslop, P. H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn785 · Cited by 512 · see citing works

Interleukin-1β Promotes Repair of the CNS

Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502 · see citing works

The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.

Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K., & Nabeshima, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00926-0 · Cited by 500 · see citing works

Role of toll-like receptor signalling in A uptake and clearance

Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works

PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage

Pringle, N. P., Mudhar, H. S., Collarini, E. J., & Richardson, W. D. (1992) · Development · doi:10.1242/dev.115.2.535 · Cited by 442 · see citing works

Glial specification in the vertebrate neural tube

Rowitch, D. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1389 · Cited by 432 · see citing works

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Town, T., Laouar, Y., Pittenger, C., Mori, T., Szekely, C. A., Tan, J., Duman, R. S., & Flavell, R. A. (2008) · Nature Medicine · doi:10.1038/nm1781 · Cited by 422 · see citing works

Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain

Zhang, J., Shi, X., Echeverry, S., Mogil, J. S., Koninck, Y. D., & Rivest, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3016-07.2007 · Cited by 421 · see citing works

Molecular insights on the cerebral innate immune system

Rivest, S. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00055-7 · Cited by 417 · see citing works

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416 · see citing works

Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

Chakravarty, S., & Herkenham, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4268-04.2005 · Cited by 396 · see citing works

Cultured astrocytes express toll‐like receptors for bacterial products

Bowman, C. C., Rasley, A., Tranguch, S. L., & Marriott, I. (2003) · Glia · doi:10.1002/glia.10256 · Cited by 395 · see citing works

Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393 · see citing works

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a Randomized, Controlled Trial of Naproxen and Celecoxib

(2008) · Archives of Neurology · doi:10.1001/archneur.2008.65.7.nct70006 · Cited by 387 · see citing works

Neuroprotective role of the innate immune system by microglia

Glezer, I., Simard, A. R., & Rivest, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.055 · Cited by 371 · see citing works

Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

Getts, D. R., Terry, R. L., Getts, M. T., Müller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I. L., & King, N. J. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080421 · Cited by 360 · see citing works

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide

Liu, Y., Walter, S., Stagi, M., Cherny, D., Letièmbre, M., Schulz‐Schaeffer, W., Heine, H., Penke, B., Neumann, H., & Fassbender, K. C. (2005) · Brain · doi:10.1093/brain/awh531 · Cited by 344 · see citing works

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

Quan, N., Whiteside, M., & Herkenham, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00350-3 · Cited by 335 · see citing works

Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions

Horn, K. P., Busch, S. A., Hawthorne, A. L., van Rooijen, N., & Silver, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2488-08.2008 · Cited by 332 · see citing works

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

O'Neill, L. A. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.004 · Cited by 327 · see citing works

Toll‐like receptor (TLR)‐2 and TLR‐4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury

Kigerl, K. A., Lai, W., Rivest, S., Hart, R. P., Satoskar, A. R., & Popovich, P. G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04524.x · Cited by 298 · see citing works

Toll‐like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators

Bsibsi, M., Persoon-Deen, C., Verwer, R. W. H., Meeuwsen, S., Ravid, R., & van Noort, J. M. (2006) · Glia · doi:10.1002/glia.20328 · Cited by 296 · see citing works

Neuronal injury in bacterial meningitis: mechanisms and implications for therapy

Nau, R., & Brück, W. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02024-5 · Cited by 295 · see citing works

Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis

Ma, Y., Li, J., Chiu, I., Wang, Y., Sloane, J., Lu, J.-N., Kosaras, B., Sidman, R., Volpe, J., & Vartanian, T. (2006) · Journal of Cell Biology · doi:10.1083/jcb.200606016 · Cited by 284 · see citing works

Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

Rolls, A., Shechter, R., London, A., Segev, Y., Jacob–Hirsch, J., Amariglio, N., Rechavi, G., & Schwartz, M. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050171 · Cited by 272 · see citing works

Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils

Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0975 · Cited by 271 · see citing works

Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo

Priller, J., Persons, D. A., Fernández‐Klett, F., Kempermann, G., Kreutzberg, G. W., & Dirnagl, U. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105103 · Cited by 266 · see citing works

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid β_1–42and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

Richard, K. L., Filali, M., Préfontaine, P., & Rivest, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1146-08.2008 · Cited by 261 · see citing works

Toll-Like Receptor Signaling Is Critical for Wallerian Degeneration and Functional Recovery after Peripheral Nerve Injury

Boivin, A., Pineau, I., Barrette, B., Filali, M., Vallières, N., Rivest, S., & Lacroix, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3027-07.2007 · Cited by 260 · see citing works

Acute Bacterial Meningitis in Adults

Sigurðardóttir, B. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440250077009 · Cited by 259 · see citing works

Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice

Xin, M., Yue, T., Ma, Z.-Y., Wu, F.-F., Gow, A., & Lu, Q. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-04.2005 · Cited by 253 · see citing works

Requirement of Myeloid Cells for Axon Regeneration

Barrette, B., Hébert, M., Filali, M., Lafortune, K., Vallières, N., Gowing, G., Julien, J., & Lacroix, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1447-08.2008 · Cited by 250 · see citing works

Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals

Cameron, J. S., Alexopoulou, L., Sloane, J. A., DiBernardo, A., Ma, Y., Kosaras, B., Flavell, R. A., Strittmatter, S. M., Volpe, J. J., Sidman, R. L., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4290-06.2007 · Cited by 235 · see citing works

Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin

Fiala, M., Liu, P. T., Monteros, A. E. D. L., Rosenthal, M. J., Bernard, G. W., Ringman, J. M., Sayre, J. W., Zhang, L., Zaghi, J., Dejbakhsh, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701267104 · Cited by 233 · see citing works

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

Tang, S.-C., Lathia, J. D., Selvaraj, P. K., Jo, D.-G., Mughal, M. R., Cheng, A., Siler, D. A., Markesbery, W. R., Arumugam, T. V., & Mattson, M. P. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.014 · Cited by 232 · see citing works

Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

Gensel, J. C., Nakamura, S., Guan, Z., van Rooijen, N., Ankeny, D. P., & Popovich, P. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3992-08.2009 · Cited by 230 · see citing works

The Bacterial Endotoxin Lipopolysaccharide has the Ability to Target the Brain in Upregulating Its Membrane CD14 Receptor Within Specific Cellular Populations

Lacroix, S., Feinstein, D., & Rivest, S. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00189.x · Cited by 223 · see citing works

Powerful beneficial effects of macrophage colony-stimulating factor on -amyloid deposition and cognitive impairment in Alzheimer's disease

Boissonneault, V., Filali, M., Lessard, M., Relton, J., Wong, G., & Rivest, S. (2008) · Brain · doi:10.1093/brain/awn331 · Cited by 221 · see citing works

Role of Microglial-Derived Tumor Necrosis Factor in Mediating CD14 Transcription and Nuclear Factor κ B Activity in the Brain during Endotoxemia

Nadeau, S., & Rivest, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03456.2000 · Cited by 217 · see citing works

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

Town, T., Bai, F., Wang, T., Kaplan, A. T., Qian, F., Montgomery, R. R., Anderson, J. F., Flavell, R. A., & Fikrig, E. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.012 · Cited by 217 · see citing works

Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide

Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., & Wang, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508125200 · Cited by 214 · see citing works

Toll-Like Receptor 3 Is a Negative Regulator of Embryonic Neural Progenitor Cell Proliferation

Lathia, J. D., Okun, E., Tang, S., Griffioen, K. J. S., Cheng, A., Mughal, M. R., Laryea, G. N., Selvaraj, P., ffrench‐Constant, C., Magnus, T., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2140-08.2008 · Cited by 206 · see citing works

Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response

Nadeau, S., & Rivest, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05536.2003 · Cited by 190 · see citing works

Central Nervous System-Initiated Inflammation and Neurotrophism in Trauma: IL-1β Is Required for the Production of Ciliary Neurotrophic Factor

Herx, L. M., Rivest, S., & Yong, V. W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2232 · Cited by 190 · see citing works

Circulating cell wall components derived from gram‐negative, not gram‐positive, bacteria cause a profound induction of the gene‐encoding Toll‐like receptor 2 in the CNS

Laflamme, N., Soucy, G., & Rivest, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00603.x · Cited by 185 · see citing works

TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain

Sørensen, L. N., Reinert, L. S., Malmgaard, L., Bartholdy, C., Thomsen, A. R., & Paludan, S. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8604 · Cited by 181 · see citing works

Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab

Martin, M. D. P. (2008) · Archives of Neurology · doi:10.1001/archneur.65.12.noc80051 · Cited by 181 · see citing works

A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in Microglia

Lehnardt, S., Henneke, P., Lien, E., Kasper, D. L., Volpe, J. J., Bechmann, I., Nitsch, R., Weber, J. R., Golenbock, D. T., & Vartanian, T. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.583 · Cited by 171 · see citing works

Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells

Setzu, A., Lathia, J. D., Zhao, C., Wells, K., Rao, M. S., ffrench‐Constant, C., & Franklin, R. J. M. (2006) · Glia · doi:10.1002/glia.20371 · Cited by 171 · see citing works

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

Stevens, S. L., Ciesielski, T., Marsh, B. J., Yang, T., Homen, D. S., Boule, J.-L., Lessov, N. S., Simon, R. P., & Stenzel‐Poore, M. P. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600606 · Cited by 168 · see citing works

A Requirement for Microglial TLR4 in Leukocyte Recruitment into Brain in Response to Lipopolysaccharide

Zhou, H. Y., Lapointe, B. M., Clark, S., Zbytnuik, L. D., & Kubes, P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.8103 · Cited by 166 · see citing works

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

Scholtzova, H., Kascsak, R. J., Bates, K. A., Boutajangout, A., Kerr, D. J., Meeker, H. C., Mehta, P. D., Spinner, D. S., & Wisniewski, T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5715-08.2009 · Cited by 166 · see citing works

Tumor Necrosis Factor–α and Interleukin‐1β Play a Critical Role in the Resistance against Lethal Herpes Simplex Virus Encephalitis

Sergerie, Y., Rivest, S., & Boivin, G. (2007) · The Journal of Infectious Diseases · doi:10.1086/520094 · Cited by 165 · see citing works

Immunostimulatory CpG-DNA Activates Murine Microglia

Dalpke, A. H., Schäfer, M. K.-H., Frey, M., Zimmermann, S., Tebbe, J. J., Weihe, E., & Heeg, K. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.4854 · Cited by 161 · see citing works

Cooperation between toll‐like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram‐negative and gram‐positive bacteria

Laflamme, N., Echchannaoui, H., Landmann, R. M., & Rivest, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200323821 · Cited by 160 · see citing works

Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat

Quan, N., Whiteside, M. B., Kim, L., & Herkenham, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10985 · Cited by 159 · see citing works

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

Kılıç, Ü., Kılıç, E., Matter, C. M., Bassetti, C. L., & Hermann, D. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.03.002 · Cited by 159 · see citing works

Regulation of the Gene Encoding Tumor Necrosis Factor Alpha (TNF-α) in the Rat Brain and Pituitary in Response to Different Models of Systemic Immune Challenge

Nadeau, S., & Rivest, S. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199901000-00008 · Cited by 142 · see citing works

Bone-marrow-derived microglia: myth or reality?

Soulet, D., & Rivest, S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.04.002 · Cited by 139 · see citing works

Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation

Lalancette–Hébert, M., Phaneuf, D., Soucy, G., Weng, Y.-C., & Križ, J. (2009) · Brain · doi:10.1093/brain/awn345 · Cited by 136 · see citing works

G protein‐coupled receptor 84, a microglia‐associated protein expressed in neuroinflammatory conditions

Bouchard, C., Pagé, J., Bédard, A., Tremblay, P., & Vallières, L. (2007) · Glia · doi:10.1002/glia.20506 · Cited by 132 · see citing works

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

Klein, M., Obermaier, B., Angele, B., Pfister, H., Wagner, H., Koedel, U., & Kirschning, C. J. (2008) · The Journal of Infectious Diseases · doi:10.1086/591626 · Cited by 130 · see citing works

Tumor Necrosis Factor α But Not Interleukin 1β Mediates Neuroprotection in Response to Acute Nitric Oxide Excitotoxicity

Turrin, N. P., & Rivest, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4032-05.2006 · Cited by 129 · see citing works

Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries

Glezer, I., Lapointe, A., & Rivest, S. (2006) · The FASEB Journal · doi:10.1096/fj.05-5234fje · Cited by 126 · see citing works

Increased Glioma Growth in Mice Depleted of Macrophages

Galarneau, H., de Villeneuve, J. P., Gowing, G., Julien, J., & Vallières, L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0177 · Cited by 113 · see citing works

The role of macrophages in optic nerve regeneration

Cui, Q., Yin, Y., & Benowitz, L. I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.036 · Cited by 106 · see citing works

Drug Insight: selective agonists and antagonists of the glucocorticoid receptor

McMaster, A., & Ray, D. W. (2008) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0745 · Cited by 95 · see citing works

Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14

Nadeau, S., & Rivest, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3370 · Cited by 94 · see citing works

Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system

Soulet, D., & Rivest, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301097 · Cited by 93 · see citing works

Glucocorticoids: Protectors of the Brain during Innate Immune Responses

Glezer, I., & Rivest, S. (2004) · The Neuroscientist · doi:10.1177/1073858404263494 · Cited by 79 · see citing works

Toll-like receptor 4 restricts retinal progenitor cell proliferation

Shechter, R., Ronen, A., Rolls, A., London, A., Bakalash, S., Young, M. J., & Schwartz, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804010 · Cited by 77 · see citing works

Delayed but Not Early Glucocorticoid Treatment Protects the Host during Experimental Herpes Simplex Virus Encephalitis in Mice

Sergerie, Y., Boivin, G., Gosselin, D., & Rivest, S. (2007) · The Journal of Infectious Diseases · doi:10.1086/511987 · Cited by 76 · see citing works

Endogenous signals initiating inflammation in the injured nervous system

Pineau, I., & Lacroix, S. (2008) · Glia · doi:10.1002/glia.20763 · Cited by 75 · see citing works

Mouse model for ablation of proliferating microgliain acute CNS injuries

Gowing, G., Vallières, L., & Julien, J. (2005) · Glia · doi:10.1002/glia.20288 · Cited by 71 · see citing works

A 20-Year Overview

Bentovim, A. (2001) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781848161528_0001 · Cited by 50 · see citing works

Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain

Boivin, G., Coulombe, Z., & Rivest, S. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02057.x · Cited by 49 · see citing works

Modulation of the Innate Immune Response by NMDA Receptors Has Neuropathological Consequences

Glezer, I., Zekki, H., Scavone, C., & Rivest, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11094.2003 · Cited by 41 · see citing works

Genes Involved in the Balance between Neuronal Survival and Death during Inflammation

Glezer, I., Chernomoretz, A., David, S., Plante, M.-M., & Rivest, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000310 · Cited by 40 · see citing works

Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis

Letièmbre, M., Echchannaoui, H., Ferracin, F., Rivest, S., & Landmann, R. M. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.06.016 · Cited by 27 · see citing works

Cannabinoids in Microglia: A New Trick for Immune Surveillance and Neuroprotection

Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.004 · Cited by 26 · see citing works

CD14 receptor polymorphism and Alzheimer's disease risk

Combarros, O., Infante, J., Rodríguez‐Rodríguez, E., Llorca, J., Peña, N., Fernández‐Viadero, C., & Berciano, J. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.082 · Cited by 22 · see citing works

NLRs and the dangers of pollution and aging

Willingham, S. B., & Ting, J. P. ‐. (2008) · Nature Immunology · doi:10.1038/ni0808-831 · Cited by 17 · see citing works

Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice

Lewandowski, G. A., & Hobbs, M. V. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00159-8 · Cited by 15 · see citing works

Altered immune response to CNS viral infection in mice with a conditional knock‐down of macrophage‐lineage cells

Carmen, J., Gowing, G., Julien, J., & Kerr, D. A. (2006) · Glia · doi:10.1002/glia.20359 · Cited by 15 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works

An environment-dependent transcriptional network specifies human microglia identity

Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science · doi:10.1126/science.aal3222 · Cited by 1,220 · see citing works

Visceral influences on brain and behavior

Critchley, H. D., & Harrison, N. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.008 · Cited by 1,177 · see citing works

Emerging targets in neuroinflammation-driven chronic pain

Ji, R., Xu, Z., & Gao, Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4334 · Cited by 1,102 · see citing works

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 933 · see citing works

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808 · see citing works

Does neuroinflammation fan the flame in neurodegenerative diseases?

Frank-Cannon, T. C., Alto, L. T., McAlpine, F. E., & Tansey, M. G. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-47 · Cited by 751 · see citing works

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Friedman, B. A., Srinivasan, K., Ayalon, G., Meilandt, W. J., Lin, H., Huntley, M. A., Cao, Y., Lee, S.-H., Haddick, P. C. G., Ngu, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.066 · Cited by 662 · see citing works

Alternatively activated microglia and macrophages in the central nervous system

Franco, R., & Fernández‐Suárez, D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.003 · Cited by 650 · see citing works

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

Zhou, Y., Wang, Y., Wang, J., Stetler, R. A., & Yang, Q. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.003 · Cited by 650 · see citing works

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

Poole, S., Singhrao, S. K., Kesavalu, L. N., Curtis, M. A., & Crean, S. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121918 · Cited by 599 · see citing works

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge

Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 596 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-179 · Cited by 499 · see citing works

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

Gorina, R., Font-Nieves, M., Márquez‐Kisinousky, L., Santalucı́a, T., & Planas, A. M. (2010) · Glia · doi:10.1002/glia.21094 · Cited by 470 · see citing works

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 461 · see citing works

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., et al. (2012) · Nature Medicine · doi:10.1038/nm.2749 · Cited by 455 · see citing works

Inflammation, microglia, and alzheimer's disease

Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 440 · see citing works

The neurobiology of interoception in health and disease

Quadt, L., Critchley, H., & Garfinkel, S. N. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13915 · Cited by 447 · see citing works

Balancing the immune response in the brain: IL-10 and its regulation

Lobo‐Silva, D., Carriche, G. M., Castro, A. G., Roque, S., & Saraiva, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0763-8 · Cited by 427 · see citing works

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

Shao, W., Zhang, S., Tang, M., Zhang, X., Zhou, Z., Yin, Y., Zhou, Q., Huang, Y., Liu, Y., Wawrousek, E. F., et al. (2012) · Nature · doi:10.1038/nature11748 · Cited by 418 · see citing works

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Hutchinson, M. R., Shavit, Y., Grace, P. M., Rice, K. C., Maier, S. F., & Watkins, L. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004135 · Cited by 397 · see citing works

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

Freeman, L., Guo, H., David, C. N., Brickey, W. J., Jha, S., & Ting, J. P.-Y. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20150237 · Cited by 397 · see citing works

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

Beurel, E., Michalek, S. M., & Jope, R. S. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.007 · Cited by 378 · see citing works

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

Zhu, H., Bian, C., Yuan, J., Chu, W., Xiang, X., Chen, F., Wang, C., Feng, H., & Lin, J. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-59 · Cited by 367 · see citing works

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

Masuda, T., Tsuda, M., Yoshinaga, R., Tozaki-Saitoh, H., Ozato, K., Tamura, T., & Inoue, K. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.014 · Cited by 338 · see citing works

Choroid plexus and the blood–cerebrospinal fluid barrier in disease

Solár, P., Zamani, A., Kubíčková, L., Dubový, P., & Joukal, M. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00196-2 · Cited by 365 · see citing works

P2X4R+ microglia drive neuropathic pain

Beggs, S., Trang, T., & Salter, M. W. (2012) · Nature Neuroscience · doi:10.1038/nn.3155 · Cited by 362 · see citing works

Review: Systemic inflammation and<scp>A</scp>lzheimer's disease

Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356 · see citing works

The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood

Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., & Cardona, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100421 · Cited by 346 · see citing works

Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 347 · see citing works

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

Lin, S., Yin, Q., Zhong, Q., Lv, F., Zhou, Y., Li, J.-Q., Wang, J., Su, B., & Yang, Q. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-46 · Cited by 332 · see citing works

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

Kraft, A. D., & Harry, G. J. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8072980 · Cited by 330 · see citing works

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324 · see citing works

Identification of a microglia phenotype supportive of remyelination

Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia · doi:10.1002/glia.21266 · Cited by 358 · see citing works

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

Nie, X., Kitaoka, S., Tanaka, K., Segi‐Nishida, E., Imoto, Y., Ogawa, A., Nakano, F., Tomohiro, A., Nakayama, K., Taniguchi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.035 · Cited by 318 · see citing works

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

McCarthy, M., Nugent, B. M., & Lenz, K. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.61 · Cited by 256 · see citing works

Function of microglia and macrophages in secondary damage after spinal cord injury

Ren, Y., Zhou, X., & He, X. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.143423 · Cited by 317 · see citing works

Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction

Thackeray, J. T., Hupe, H. C., Wang, Y., Bankstahl, J. P., Berding, G., Roß, T. L., Bauersachs, J. K., Wollert, K. C., & Bengel, F. M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.024 · Cited by 302 · see citing works

Cellular infiltration in traumatic brain injury

Alam, A., Thelin, E. P., Tajsic, T., Khan, D. Z., Khellaf, A., Patani, R., & Helmy, A. E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02005-x · Cited by 298 · see citing works

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

Li, X., & Jope, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.105 · Cited by 294 · see citing works

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

Lampron, A., ElAli, A., & Rivest, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.005 · Cited by 282 · see citing works

Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

Li, L., Acioglu, C., Heary, R. F., & Elkabes, S. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.10.007 · Cited by 283 · see citing works

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271 · see citing works

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

Zattoni, M., Mura, M. L., Deprez, F., Schwendener, R. A., Engelhardt, B., Frei, K., & Fritschy, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6210-10.2011 · Cited by 267 · see citing works

Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation

Benicky, J., Sánchez-Lemus, E., Honda, M., Pang, T., Orecna, M., Wang, J., Leng, Y., Chuang, D.-M., & Saavedra, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.225 · Cited by 254 · see citing works

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

Michaud, J.-P., Bellavance, M.-A., Préfontaine, P., & Rivest, S. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.010 · Cited by 257 · see citing works

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

Michaud, J.-P., Hallé, M., Lampron, A., Thériault, P., Préfontaine, P., Filali, M., Tribout-Jover, P., Lanteigne, A.-M., Jodoin, R., Cluff, C. W., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215165110 · Cited by 251 · see citing works

Toll-like receptors in chronic pain

Nicotra, L. L., Loram, L. C., Watkins, L. R., & Hutchinson, M. R. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.038 · Cited by 250 · see citing works

Early Brain Injury After Subarachnoid Hemorrhage: Incidence and Mechanisms

Lauzier, D. C., Jayaraman, K., Yuan, J. Y., Diwan, D., Vellimana, A. K., Osbun, J. W., Chatterjee, A. R., Athiraman, U., Dhar, R., & Zipfel, G. J. (2023) · Stroke · doi:10.1161/strokeaha.122.040072 · Cited by 249 · see citing works

Rodent models of neuroinflammation for Alzheimer’s disease

Nazem, A., Sankowski, R., Bacher, M., & Al‐Abed, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0291-y · Cited by 249 · see citing works

TNFα in synaptic function: switching gears

Santello, M., & Volterra, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.001 · Cited by 245 · see citing works

Noninvasive Molecular Imaging of Neuroinflammation

Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245 · see citing works

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236 · see citing works

Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

Fillman, S. G., Sinclair, D., Fung, S. J., Webster, M. J., & Shannon Weickert, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.8 · Cited by 226 · see citing works

Age related macular degeneration and drusen: Neuroinflammation in the retina

Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230 · see citing works

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

Diz-Chaves, Y., Pernía, O., Carrero, P., & García‐Segura, L. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-71 · Cited by 233 · see citing works

Harnessing monocyte‐derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

Shechter, R., & Schwartz, M. (2012) · The Journal of Pathology · doi:10.1002/path.4106 · Cited by 225 · see citing works

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Ryu, J. K., Rafalski, V. A., Meyer-Franke, A., Adams, R. A., Poda, S. B., Rios Coronado, P. E., Pedersen, L. Ø., Menon, V., Baeten, K. M., Sikorski, S. L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0232-x · Cited by 213 · see citing works

Post-Ischemic Inflammation in the Brain

Shichita, T., Sakaguchi, R., Suzuki, M., & Yoshimura, A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00132 · Cited by 221 · see citing works

Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases

Tian, L., Ma, L., Kaarela, T., & Li, Z. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-155 · Cited by 218 · see citing works

WNT signaling in activated microglia is proinflammatory

Halleskog, C., Mulder, J., Dahlström, J., Mackie, K., Hortobágyi, T., Tanila, H., Puli, L., Färber, K., Harkany, T., & Schulte, G. (2010) · Glia · doi:10.1002/glia.21081 · Cited by 216 · see citing works

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

Papageorgiou, I. E., Lewen, A., Galow, L. V., Cesetti, T., Scheffel, J., Regen, T., Hanisch, U., & Kann, O. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513853113 · Cited by 214 · see citing works

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216 · see citing works

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

Masuda, T., Iwamoto, S., Yoshinaga, R., Tozaki‐Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Tsuda, M., & Inoue, K. (2014) · Nature Communications · doi:10.1038/ncomms4771 · Cited by 217 · see citing works

Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks

Domingues, C., Silva, O. A. B. D. C. E., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 212 · see citing works

The Role of Copper Homeostasis in Brain Disease

An, Y., Li, S., Huang, X., Chen, X., Shan, H., & Zhang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213850 · Cited by 220 · see citing works

Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice

Jin, X., Ishii, H., Bai, Z., Itokazu, T., & Yamashita, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041892 · Cited by 211 · see citing works

Dicer ablation in oligodendrocytes provokes neuronal impairment in mice

Shin, D., Shin, J., McManus, M. T., Ptáček, L. J., & Fu, Y. (2009) · Annals of Neurology · doi:10.1002/ana.21927 · Cited by 207 · see citing works

Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia

McArthur, S., Cristante, E., Paterno, M., Christian, H., Roncaroli, F., Gillies, G. E., & Solito, E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001095 · Cited by 209 · see citing works

Biological role of Toll-like receptor-4 in the brain

Trotta, T., Porro, C., Calvello, R., & Panaro, M. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.01.014 · Cited by 204 · see citing works

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system

Leszek, J., E. Barreto, G., G|siorowski, K., Koutsouraki, E., Ávila-Rodrigues, M., & Aliev, G. (2016) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160202125914 · Cited by 206 · see citing works

Oncomodulin links inflammation to optic nerve regeneration

Yin, Y., Cui, Q., Gilbert, H.-Y., Yang, Y., Yang, Z., Berlinicke, C. A., Li, Z., Zaverucha-do-Valle, C., He, H., Petkova, V., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907085106 · Cited by 205 · see citing works

Functional diversity of microglia – how heterogeneous are they to begin with?

Hanisch, U.-K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00065 · Cited by 195 · see citing works

Innate Immunity and Neuroinflammation

Shastri, A., Bonifati, D. M., & Kishore, U. (2013) · Mediators of Inflammation · doi:10.1155/2013/342931 · Cited by 201 · see citing works

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

Fülöp, T., Witkowski, J. M., Bourgade, K., Khalil, A., Zerif, E., Larbi, A., Hirokawa, K., Pawelec, G., Bocti, C., Lacombe, G., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00224 · Cited by 201 · see citing works

Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain

Trang, T., Beggs, S., & Salter, M. W. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000087 · Cited by 197 · see citing works

Inflammation in Parkinson's Disease

Tüfekçi, K. U., Meuwissen, R. L. J., Genç, Ş., & Genç, K. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00004-0 · Cited by 199 · see citing works

Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology

Peery, H. E., Day, G. S., Dunn, S. E., Fritzler, M. J., Prüß, H., Souza, C. M. D., Doja, A., Mossman, K. L., Resch, L., Xia, C., et al. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.001 · Cited by 191 · see citing works

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 189 · see citing works

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

Akundi, R. S., Huang, Z., Eason, J., Pandya, J. D., Zhi, L., Cass, W. A., Sullivan, P. G., & Büeler, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016038 · Cited by 187 · see citing works

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

Franco, R., & Cedazo-Minguez, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00146 · Cited by 183 · see citing works

Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence

Coller, J. K., & Hutchinson, M. R. (2012) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2012.01.008 · Cited by 186 · see citing works

The link between chronic pain and Alzheimer’s disease

Cao, S., Fisher, D. W., Yu, T., & Dong, H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1608-z · Cited by 183 · see citing works

Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

Kabir, M. T., Rahman, M. H., Shah, M., Jamiruddin, M. R., Basak, D., Al‐Harrasi, A., Bhatia, S., Ashraf, G. M., Najda, A., El-kott, A. F., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112610 · Cited by 184 · see citing works

Ethanol induces TLR 4/ TLR 2 association, triggering an inflammatory response in microglial cells

Fernández‐Lizarbe, S., Montesinos, J., & Guerri, C. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12276 · Cited by 182 · see citing works

Can oral infection be a risk factor for Alzheimer's disease?

Olsen, I., & Singhrao, S. K. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.29143 · Cited by 182 · see citing works

Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders

Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00016 · Cited by 174 · see citing works

Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease

ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B. (2017) · Physiological Research · doi:10.33549/physiolres.933480 · Cited by 167 · see citing works

Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice

Kenne, E. M., Erlandsson, A., Lindbom, L., Hillered, L., & Clausen, F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-17 · Cited by 169 · see citing works

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Anderson, S. T., Commins, S., Moynagh, P. N., & Coogan, A. N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.007 · Cited by 169 · see citing works

Neuroinflammation, Microglia and Mast Cells in the Pathophysiology of Neurocognitive Disorders: A Review

Skaper, S. D., Facci, L., & Giusti, P. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130224206 · Cited by 168 · see citing works

Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives

McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 167 · see citing works

Sphingolipids: Critical players in Alzheimer’s disease

van Echten‐Deckert, G., & Walter, J. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.07.001 · Cited by 172 · see citing works

Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors α and β

Brown, C. M., Mulcahey, T. A., Filipek, N. C., & Wise, P. M. (2010) · Endocrinology · doi:10.1210/en.2010-0371 · Cited by 166 · see citing works

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer’s disease triple transgenic mouse model

Guedes, J. R., Custódia, C. M., Silva, R. J., de Almeida, L. P., Pedroso de Lima, M. C., & Cardoso, A. L. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu348 · Cited by 150 · see citing works

Neuropathology of mood disorders: Do we see the stigmata of inflammation?

Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165 · see citing works

Molecular and cellular immune mediators of neuroprotection

Turrin, N. P., & Rivest, S. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:3:221 · Cited by 85 · see citing works

Microglia and their roles in response to injury of the central nervous system

Jia, Y. (2012) · Yixue yanjiusheng xuebao · Cited by 2 · see citing works

The role of the microglia in acute CNS injury

Kawabori, M., & Yenari, M. A. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9531-6 · Cited by 138 · see citing works

The Brain innate immune response in neuroprotection and repair

Serge, R. (2009) · Frontiers in Neuroscience · doi:10.3389/conf.neuro.01.2009.11.001

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works