The DOI matches its Crossref record.
DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction
Abstract
Establishment of mesodermal tissues in the amphibian body involves a series of inductive interactions probably elicited by a variety of peptide growth factors. Results reported here suggest that mesodermal patterning involves an array of signalling molecules including DVR-4, a TGF-β-like molecule. We show that ectopic expression of DVR-4 causes embryos to develop with an overall posterior and/or ventral character, and that DVR-4 induces ventral types of mesoderm in animal cap explants. Moreover, DVR-4 overrides the dorsalizing effects of activin. DVR-4 is therefore the first molecule reported both to induce posteroventral mesoderm and to counteract dorsalizing signals such as activin. Possible interactions between these molecules resulting in establishment of the embryonic body plan are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839
A common plan for dorsoventral patterning in Bilateria
De Robertis, E. M., & Sasai, Y. (1996) · Nature · doi:10.1038/380037a0 · Cited by 780
Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells
Hollnagel, A., Oehlmann, V., Heymer, J., Rüther, U., & Nordheim, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19838 · Cited by 527
Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.81 · Cited by 420
Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo
Frasch, M. (1995) · Nature · doi:10.1038/374464a0 · Cited by 414
Metadata
- Authors
- Jones, C. M., Lyons, K. M., An, P. M. L., Wright, C. V. E., & Hogan, B. L. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-06-01
- Volume
- 115
- Issue
- 2
- Pages
- 639-647
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2130662470
- Cited by
- 477
- References
- 0
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. https://app.cochat.ai/papers/10.1242/dev.115.2.639
- The paper
- Jones, C. M., Lyons, K. M., An, P. M. L., Wright, C. V. E., & Hogan, B. L. M. (1992). DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development. https://doi.org/10.1242/dev.115.2.639
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
