The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction
Abstract
Establishment of mesodermal tissues in the amphibian body involves a series of inductive interactions probably elicited by a variety of peptide growth factors. Results reported here suggest that mesodermal patterning involves an array of signalling molecules including DVR-4, a TGF-β-like molecule. We show that ectopic expression of DVR-4 causes embryos to develop with an overall posterior and/or ventral character, and that DVR-4 induces ventral types of mesoderm in animal cap explants. Moreover, DVR-4 overrides the dorsalizing effects of activin. DVR-4 is therefore the first molecule reported both to induce posteroventral mesoderm and to counteract dorsalizing signals such as activin. Possible interactions between these molecules resulting in establishment of the embryonic body plan are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs
Krieg, P. A., & Melton, D. A. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7057 · Cited by 1,533
The origin of pattern and polarity in the Drosophila embryo
Johnston, D. S., & Nüsslein-Volhard, C. (1992) · Cell · doi:10.1016/0092-8674(92)90466-p · Cited by 1,361
Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D., & Herrmann, B. G. (1991) · Cell · doi:10.1016/0092-8674(91)90573-h · Cited by 971
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors
Slack, J. M. W., Darlington, B. G., Heath, J. K., & Godsave, S. F. (1987) · Nature · doi:10.1038/326197a0 · Cited by 933
[25] In vitro RNA synthesis with SP6 RNA polymerase
Krieg, P. A., & Melton, D. A. (1987) · Methods in Enzymology · doi:10.1016/0076-6879(87)55027-3 · Cited by 719
Jones, C. M., Lyons, K. M., & Hogan, B. L. M. (1991) · Development · doi:10.1242/dev.111.2.531 · Cited by 650
Self-citationSmith, W. C., & Harland, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90070-f · Cited by 647
Lyons, K. M., Pelton, R. W., & Hogan, B. L. M. (1990) · Development · doi:10.1242/dev.109.4.833 · Cited by 614
Self-citationFate map for the 32-cell stage of Xenopus laevis
Dale, L., & Slack, J. M. W. (1987) · Development · doi:10.1242/dev.99.4.527 · Cited by 507
Injected Wnt RNA induces a complete body axis in Xenopus embryos
Sokol, S., Christian, J. L., Moon, R. T., & Melton, D. A. (1991) · Cell · doi:10.1016/0092-8674(91)90069-b · Cited by 506
Cited by
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
Zimmerman, L. B., De Jesús-Escobar, J. M., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,633
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839
A common plan for dorsoventral patterning in Bilateria
De Robertis, E. M., & Sasai, Y. (1996) · Nature · doi:10.1038/380037a0 · Cited by 780
Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells
Hollnagel, A., Oehlmann, V., Heymer, J., Rüther, U., & Nordheim, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19838 · Cited by 527
Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer
Nishita, M., Hashimoto, M. K., Ogata, S., Laurent, M. N., Ueno, N., Shibuya, H., & Cho, K. W. Y. (2000) · Nature · doi:10.1038/35001602 · Cited by 465
Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90409-x · Cited by 451
Christian, J. L., & Moon, R. T. (1993) · Genes & Development · doi:10.1101/gad.7.1.13 · Cited by 447
Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.81 · Cited by 420
Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo
Frasch, M. (1995) · Nature · doi:10.1038/374464a0 · Cited by 414
Vassalli, A., Matzuk, M. M., Gardner, H. A., Lee, K. F., & Jaenisch, R. (1994) · Genes & Development · doi:10.1101/gad.8.4.414 · Cited by 398
On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.
Fainsod, A., Steinbeisser, H., & De Robertis, E. M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06830.x · Cited by 395
dino and mercedes , two genes regulating dorsal development in the zebrafish embryo
Hammerschmidt, M., Pelegri, F., Mullins, M. C., Kane, D. A., Eeden, F. J. M. V., Granato, M., Brand, M., Furutani-Seiki, M., Haffter, P., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.95 · Cited by 323
Ying, Y., Qi, X., & Zhao, G.-Q. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151242798 · Cited by 306
Xwnt-11: a maternally expressed Xenopus wnt gene
Ku, M., & Melton, D. A. (1993) · Development · doi:10.1242/dev.119.4.1161 · Cited by 304
Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.
Padgett, R. W., Wozney, J. M., & Gelbart, W. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2905 · Cited by 280
Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., & Niehrs, C. (1996) · Development · doi:10.1242/dev.122.10.3045 · Cited by 270
BMP signaling and early embryonic patterning
Kishigami, S., & Mishina, Y. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.002 · Cited by 265
Endogenous patterns of TGFβ superfamily signaling during early Xenopus development
Faure, S., Lee, M. A., Keller, T., Dijke, P. T., & Whitman, M. (2000) · Development · doi:10.1242/dev.127.13.2917 · Cited by 257
Lieschke, G. J., Oates, A. C., Paw, B. H., Thompson, M. A., Hall, N. E., Ward, A. C., Ho, R. K., Zon, L. I., & Layton, J. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0657 · Cited by 183
Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms
Holley, S. A., & Ferguson, E. L. (1997) · BioEssays · doi:10.1002/bies.950190404 · Cited by 122
Structural and functional analysis of the BMP-4 promoter in early embryos of xenopus laevis.
Metz, A., Knöchel, S., Büchler, P., Köster, M., & Knöchel, W. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00059-8 · Cited by 42
Metadata
- Authors
- Jones, C. M., Lyons, K. M., An, P. M. L., Wright, C. V. E., & Hogan, B. L. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-06-01
- Volume
- 115
- Issue
- 2
- Pages
- 639-647
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2130662470
- Cited by
- 477
- References
- 24
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
