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Cited by 441

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

A dominant mutation in the maize homeobox gene, Knotted-1, causes its ectopic expression in leaf cells with altered fates

Smith, Laurie G., Greene, Ben, Veit, Bruce, Hake, Sarah·1992·Development
DOI 10.1242/dev.116.1.21
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Abstract

Dominant mutations of the Knotted-1 (Kn1) homeobox gene of maize alter the differentiation and growth of cells associated with leaf veins. By analyzing Kn1 transcripts and KN1 protein, we show that the gene is not expressed at high levels during the development of wildtype leaves. Instead, Kn1 is expressed in apical meristems of vegetative and floral shoots, and is downregulated as leaves and floral organs are initiated. Kn1 is also expressed in relatively undifferentiated cells within developing vascular bundles, as well as ground tissue, in immature, unelongated axes of wild-type vegetative and floral shoots. In Kn1-N2 mutant plants, quantitative, but not qualitative differences are apparent in Kn1 transcripts and KN1 protein, consistent with previous observations that dominant Kn1 mutations map to noncoding regions of the gene. Kn1 is expressed ectopically in vascular bundles within developing mutant leaves in a pattern that correlates with the phenotypic alterations produced by the Kn1-N2 mutation. Thus, Kn1 apparently alters the fates of leaf cells in which it is ectopically expressed from an early stage of leaf development. Based on these observations, we hypothesize that Kn1 functions in its wild-type context as a regulator of cell determination.

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Metadata

Authors
Smith, L. G., Greene, B., Veit, B., & Hake, S.
Venue
Development
Publisher
The Company of Biologists
Published
1992-09-01
Volume
116
Issue
1
Pages
21-30
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.116.1.21
OpenAlex
W2112757930
Cited by
441
References
30
FWCI
21.84
Type
journal article
Language
en
Open access
closed

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