The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Why we have (only) five fingers per hand: Hox genes and the evolution of paired limbs
Abstract
Limb development has long been a model system for studying vertebrate pattern formation. The advent of molecular biology has allowed the identification of some of the key genes that regulate limb morphogenesis. One important class of such genes are the homeobox-containing, or Hox genes. Understanding of the roles these genes play in development additionally provides insights into the evolution of limb pattern. Hox gene expression patterns divide the embryonic limb bud into five sectors along the anterior/posterior axis. The expression of specific Hox genes in each domain specifies the developmental fate of that region. Because there are only five distinct Hox-encoded domains across the limb bud there is a developmental constraint prohibiting the evolution of more than five different types of digits. The expression patterns of Hox genes in modern embryonic limb buds also gives clues to the shape of the ancestral fin field from which the limb evolved, hence elucidating the evolution of the tetrapod limb.
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(1990) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040628 · Cited by 198
Cited by
The development of the paired fins in the zebrafish (Danio rerio).
Grandel, H., & Schulte-Merker, S. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00176-2 · Cited by 267
Coates, M. I. (1996) · Transactions of the Royal Society of Edinburgh: Earth Sciences · doi:10.1017/s0263593300006787 · Cited by 260
The origin of vertebrate limbs
Coates, M. I. (1994) · Development · doi:10.1242/dev.1994.supplement.169 · Cited by 209
Eastwick, P. W. (2009) · Psychological Bulletin · doi:10.1037/a0016845 · Cited by 116
PETERSON, K. J., SUMMONS, R. E., & DONOGHUE, P. C. J. (2007) · Palaeontology · doi:10.1111/j.1475-4983.2007.00692.x · Cited by 93
Metadata
- Authors
- Tabin, C. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-10-01
- Volume
- 116
- Issue
- 2
- Pages
- 289-296
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1853437144
- Cited by
- 188
- References
- 1
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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