Cited by 168Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesReproductive Biology and FertilitySperm and Testicular Function

The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse

Burgoyne, P. S., Thornhill, A. R., Boudrean, S. Kalmus, Darling, S. M., Bishop, C. E., Evans, E. P.·1995·Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

Abstract

There is now a substantial body of data showing that in eutherian mammals (mouse, rat, cow and man) XY conceptuses are developmentally more advanced (and consequently larger) than XX conceptuses of equivalent gestational age. This developmental difference is already discernible in the preimplantation period and it has been suggested that the more advanced development of XY embryos may be a consequence of the preimplantation expression of Y chromosomal genes such as Sry or Zfy. In the present paper sex-chromosomally variant mice were used to analyse the genetic basis of XX-XY differences as manifest at 10.5 days post coitum. The results show that the XX-XY difference is due to a combination of a Y chromosome effect and an effect of the difference in X chromosome constitution (2X v 1X). The Y effect is not dependent on the presence of Sry. In the light of this and other studies, it is concluded that the Y chromosome of most mouse strains carries a factor which accelerates preimplantation development and that the resulting developmental advantage is carried over into the postimplantation period. The retarding effect of two X chromosomes is then superimposed on this Y effect subsequent to the blastocyst stage but prior to 9.5 days post coitum.

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Crossref · 10.1098/rstb.1995.0159

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Authors
Burgoyne, P. S., Thornhill, A. R., Boudrean, S. K., Darling, S. M., Bishop, C. E., & Evans, E. P.
Affiliations
  • National Institute for Medical Research (GB)
  • MRC Mammalian Development Unit, Wolfson House, 4 Stephenson Way, London NW1 2HE, U. K.
  • University College London (GB)
  • Inserm (FR)
  • MRC Radiobiology Unit, Chilton, Didcot, Oxon OX11 0RD, U. K.
Venue
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
Published
1995-11-29
Volume
350
Issue
1333
Pages
253-261
ISSN
  • 0962-8436 (ISSN-L)
  • 1471-2970
OpenAlex
W2119156348
Cited by
168
References
37
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 15 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 5 · 2012: 6
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Locations
  • Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
preimplantation embryo development, Y chromosome, SRY, ZFY, mouse embryo, developmental rate, X chromosome dosage, gonadal sex differentiation, blastocyst
MeSH terms
Animals, Body Weight, Female, Embryonic and Fetal Development, Gonads, Longitudinal Studies, Male, Sex Determination Analysis, X Chromosome, Y Chromosome, Mice

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