The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Analysis of genetic mosaics in developing and adult Drosophila tissues
Abstract
We have constructed a series of strains to facilitate the generation and analysis of clones of genetically distinct cells in developing and adult tissues of Drosophila. Each of these strains carries an FRT element, the target for the yeast FLP recombinase, near the base of a major chromosome arm, as well as a gratuitous cellautonomous marker. Novel markers that carry epitope tags and that are localized to either the cell nucleus or cell membrane have been generated. As a demonstration of how these strains can be used to study a particular gene, we have analyzed the developmental role of the Drosophila EGF receptor homolog. Moreover, we have shown that these strains can be utilized to identify new mutations in mosaic animals in an efficient and unbiased way, thereby providing an unprecedented opportunity to perform systematic genetic screens for mutations affecting many biological processes.
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Citations
Cites
Mutations affecting segment number and polarity in Drosophila
Nüsslein-Volhard, C., & Wieschaus, E. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370
The Genetics and Biology of Drosophila
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The Genome of Drosophila Melanogaster
Lindsley, D. L., & Zimm, G. G. (1992) · Cited by 3,098
Genetic Transformation of Drosophila with Transposable Element Vectors
Rubin, G. M., & Spradling, A. C. (1982) · Science · doi:10.1126/science.6289436 · Cited by 3,014
Self-citationDrosophila — A Practical Approach
(1987) · Biochemical Education · doi:10.1016/0307-4412(87)90074-4 · Cited by 1,802
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The Genetics and Biology of Drosophila
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N�sslein-Volhard, C., Wieschaus, E., & Kluding, H. (1984) · Wilhelm Roux's Archives of Developmental Biology · doi:10.1007/bf00848156 · Cited by 1,546
Drosophila: A laboratory handbook
Kyriacou, C. P. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90285-j · Cited by 1,242
Wharton, K. A., Johansen, K. M., Xu, T., & Artavanis-Tsakonas, S. (1985) · Cell · doi:10.1016/0092-8674(85)90229-6 · Cited by 1,060
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Items 101–104 of 104
Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila
Vuong, L. T., Mukhopadhyay, B., & Choi, K.-W. (2014) · Development · doi:10.1242/dev.106229 · Cited by 21
Characterization of Autophagic Responses in Drosophila melanogaster
Xu, T., Kumar, S., & Denton, D. (2017) · Methods in Enzymology · doi:10.1016/bs.mie.2016.09.089 · Cited by 12
Self-citationAzlan, A., & Fukunaga, R. (2025) · PLOS Genetics · doi:10.1371/journal.pgen.1011792
(2025) · doi:10.7554/elife.103828.4
Metadata
- Authors
- Xu, T., & Rubin, G. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-04-01
- Volume
- 117
- Issue
- 4
- Pages
- 1223-1237
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2159935247
- Cited by
- 2,041
- References
- 44
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- closed
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