The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor
Abstract
Although normal cell death is known to occur in many developing vertebrate organs, it has not been thought to play an important part in the development of the mammalian kidney. We show here that normal cell death is found in both the nephrogenic region and medullary papilla of the developing rat kidney and, in each of these areas, it follows a distinct developmental time course. As many as 3% of the cells in these areas have a typical apoptotic morphology and the dead cells seem to be cleared rapidly (within 1-2 hours) by phagocytosis by neighbouring parenchymal cells. These values are similar to those in vertebrate neural tissues where 50% or more of the cells die during normal development, suggesting that large-scale death is a normal feature of kidney development. We also show that in vivo treatment with epidermal growth factor inhibits cell death in the developing kidney, consistent with the possibility that the cells normally die because they lack sufficient survival factors. Our findings suggest that the extent of normal cell death in developing animals is still greatly underestimated and they raise the possibility that many of these cell deaths may reflect limiting amounts of survival factors.
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Cites
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Cited by
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & Raff, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,698
Self-citationDevelopmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
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Dedifferentiation and Proliferation of Surviving Epithelial Cells in Acute Renal Failure
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Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme
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Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim
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Programmed cell death and the control of cell survival
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Self-citationApoptotic bone cells may be engulfed by osteoclasts during alveolar bone resorption in young rats
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Metadata
- Authors
- Coles, H. S. R., Burne, J. F., & Raff, M. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-07-01
- Volume
- 118
- Issue
- 3
- Pages
- 777-784
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2132963869
- Cited by
- 426
- References
- 4
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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