Apoptotic bone cells may be engulfed by osteoclasts during alveolar bone resorption in young rats
Abstract
The alveolar bone is a suitable in vivo physiological model for the study of apoptosis and interactions of bone cells because it undergoes continuous, rapid and intense resorption/remodelling, during a long period of time, to accommodate the growing tooth germs. The intensity of alveolar bone resorption greatly enhances the chances of observing images of the extremely rapid events of apoptosis of bone cells and also of images of interactions between osteoclasts and osteocytes/osteoblasts/bone lining cells. To find such images, we have therefore examined the alveolar bone of young rats using light microscopy, the TUNEL method for apoptosis, and electron microscopy. Fragments of alveolar bone from young rats were fixed in Bouin and formaldehyde for morphology and for the TUNEL method. Glutaraldehyde-formaldehyde fixed specimens were processed for transmission electron microscopy. Results showed TUNEL positive round/ovoid structures on the bone surface and inside osteocytic lacunae. These structures--also stained by hematoxylin--were therefore interpreted, respectively, as osteoblasts/lining cells and osteocytes undergoing apoptosis. Osteoclasts also exhibited TUNEL positive apoptotic bodies inside large vacuoles; the nuclei of osteoclasts, however, were always TUNEL negative. Ultrathin sections revealed typical apoptotic images--round/ ovoid bodies with dense crescent-like chromatin--on the bone surface, corresponding therefore to apoptotic osteoblasts/lining cells. Osteocytes also showed images compatible with apoptosis. Large osteoclast vacuoles often contained fragmented cellular material. Our results provide further support for the idea that osteoclasts internalize dying bone cells; we were however, unable to find images of osteoclasts in apoptosis.
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During bone resorption, apoptotic osteocytes are engulfed by osteoclasts.
“In agreement, it has been shown that during bone resorption, apoptotic osteocytes are engulfed by osteoclasts [74–76].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [74]
Osteoclasts engulf apoptotic osteocytes.
“Accordingly, it has been reported that osteoclasts engulf apoptotic osteocytes [74, 75, 192], suggesting that osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site (Figures 4(c) and 4(d)).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [74]
Osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site.
“Accordingly, it has been reported that osteoclasts engulf apoptotic osteocytes [74, 75, 192], suggesting that osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site (Figures 4(c) and 4(d)).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [74]
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- Authors
- Boabaid, F., Cerri, P. S., & Katchburian, E.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- ORCID
- Cerri, P.S.
- Venue
- Tissue and Cell
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 33
- Issue
- 4
- Pages
- 318-325
- ISSN
- 0040-8166 (ISSN-L)
- OpenAlex
- W2005128372
- Cited by
- 53
- References
- 38
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tissue and Cell (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- apoptosis, osteoclasts, alveolar bone loss, osteocytes, osteoblasts, bone lining cells, apoptotic bodies, tooth germ, bone remodeling, young rats
- MeSH terms
- Tartrate-Resistant Acid Phosphatase, Acid Phosphatase, Alveolar Process, Animals, Animals, Newborn, Bone Resorption, Female, Isoenzymes, Male, Microscopy, Electron, Osteoblasts, Osteoclasts, Osteocytes, Phagocytosis, Staining and Labeling, Biomarkers, Bone Remodeling, Rats, Wistar, Apoptosis, In Situ Nick-End Labeling, Rats
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