Programmed cell death and the control of cell survival
Abstract
We draw the following tentative conclusions from our studies on programmed cell death (PCD): (i) the amount of normal cell death in mammalian development is still underestimated; (ii) most mammalian cells constitutively express the proteins required to undergo PCD; (iii) the death programme operates by default when a mammalian cell is deprived of signals from other cells; (iv) many normal cell deaths may occur because cells fail to obtain the extracellular signals they need to suppress the death programme; and (v) neither the nucleus nor mitochondrial respiration is required for PCD (or Bcl-2 protection from PCD), raising the possibility that the death programme, like mitosis, is orchestrated by a cytosolic regulator that acts on multiple organelles in parallel.
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In many cell types the intrinsic apoptosis pathway can be activated by withdrawal of specific hormones that normally suppress the apoptotic pathway.
“In many cell types the intrinsic pathway can be activated by the withdrawal of specific hormones that normally act to suppress the apoptotic pathway(Raff et al., 1994).”
From Programmed cell death in aging (2015) · cites this paper as Raff et al., 1994
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Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
Programmed cell death in aging
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- Authors
- Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S. R., Ishizaki, Y., & Jacobson, M. D.
- Affiliations
- MRC Laboratory for Molecular Cell Biology (GB)
- Venue
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 1994-08-30
- Volume
- 345
- Issue
- 1313
- Pages
- 265-268
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W1976698766
- Cited by
- 166
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 5
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- programmed cell death, apoptosis, cell survival, mammalian development, extracellular signals, Bcl-2, mitochondrial respiration, developmental cell death
- MeSH terms
- Animals, Cartilage, Cell Survival, Kidney, Lens, Crystalline, Oligodendroglia, Apoptosis
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