The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Selective accumulation of MyoD and Myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones
Abstract
Each of the myogenic helix-loop-helix transcription factors (MyoD, Myogenin, Myf-5, and MRF4) is capable of activating muscle-specific gene expression, yet distinct functions have not been ascribed to the individual proteins. We report here that MyoD and Myogenin mRNAs selectively accumulate in hindlimb muscles of the adult rat that differ in contractile properties: MyoD is prevalent in fast twitch and Myogenin in slow twitch muscles. The distribution of MyoD and Myogenin transcripts also differ within a single muscle and correlate with the proportions of fast glycolytic and slow oxidative muscle fibres, respectively. Furthermore, the expression of a transgene consisting of a muscle-specific cis-regulatory region from the myoD gene controlling lacZ was primarily associated with the fast glycolytic fibres. Alteration of the fast/slow fibre type distribution by thyroid hormone treatment or by cross-reinnervation resulted in a corresponding alteration in the MyoD/Myogenin mRNA expression pattern. These findings show that the expression of specific myogenic helix-loop-helix regulators is under the control of innervation and humoral factors and may mediate differential control of contractile protein gene expression in adult muscle.
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Cites
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The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
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Self-citationMyogenin, a factor regulating myogenesis, has a domain homologous to MyoD
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Cited by
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Myogenic satellite cells: physiology to molecular biology
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Hespel, P., Op't Eijnde, B., Leemputte, M. V., Ursø, B., Greenhaff, P. L., Labarque, V., Dymarkowski, S., Hecke, P. V., & Richter, E. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0625c.xd · Cited by 335
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Metadata
- Authors
- Hughes, S. M., Taylor, J. M., Tapscott, S. J., Gurley, C. M., Carter, W. J., & Peterson, C. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-08-01
- Volume
- 118
- Issue
- 4
- Pages
- 1137-1147
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1837450065
- Cited by
- 422
- References
- 71
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selective accumulation of MyoD and Myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones. https://app.cochat.ai/papers/10.1242/dev.118.4.1137
- The paper
- Hughes, S. M., Taylor, J. M., Tapscott, S. J., Gurley, C. M., Carter, W. J., & Peterson, C. A. (1993). Selective accumulation of MyoD and Myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones. Development. https://doi.org/10.1242/dev.118.4.1137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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