The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans
Abstract
In the 4-cell Caenorhabditis elegans embryo, two blastomeres are destined to generate pharyngeal cells, each by a distinct developmental strategy: one pathway is inductive, while the other is autonomous. Here, we identify the pha-4 locus. In animals lacking pha-4 activity, an early step in pharyngeal organogenesis is blocked: no pharyngeal primordium is formed and differentiated pharyngeal cells are absent. Most other tissues are generated normally in pha-4 mutants, including cells related to pharyngeal cells by cell lineage and position. Thus, pha-4 activity is required to form the pharyngeal primordium. We propose that pha-4 marks a convergence of the inductive and autonomous pathways of pharyngeal development and suggest that establishment of pharyngeal organ identity is a crucial step for pharyngeal organogenesis.
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Genetic control of programmed cell death in the nematode C. elegans
Ellis, H. (1986) · Cell · doi:10.1016/0092-8674(86)90004-8 · Cited by 1,828
The pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649
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Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766
The evolution of Fox genes and their role in development and disease
Hannenhalli, S., & Kaestner, K. H. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2523 · Cited by 658
Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 572
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Metadata
- Authors
- Mango, S. E., Lambie, E. J., & Kimble, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-10-01
- Volume
- 120
- Issue
- 10
- Pages
- 3019-3031
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1924615382
- Cited by
- 187
- References
- 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mango, S. E., Lambie, E. J., & Kimble, J. (1994). The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans. Development. https://doi.org/10.1242/dev.120.10.3019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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