The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
The evolution of Fox genes and their role in development and disease
Open accessAbstract
The forkhead box (Fox) family of transcription factors, which originated in unicellular eukaryotes, has expanded over time through multiple duplication events, and sometimes through gene loss, to over 40 members in mammals. Fox genes have evolved to acquire a specialized function in many key biological processes. Mutations in Fox genes have a profound effect on human disease, causing phenotypes as varied as cancer, glaucoma and language disorders. We summarize the salient features of the evolution of the Fox gene family and highlight the diverse contribution of various Fox subfamilies to developmental processes, from organogenesis to speech acquisition.
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Cites
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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A forkhead-domain gene is mutated in a severe speech and language disorder
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Molecular evolution of FOXP2, a gene involved in speech and language
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Cited by
Pioneer transcription factors: establishing competence for gene expression
Zaret, K. S., & Carroll, J. S. (2011) · Genes & Development · doi:10.1101/gad.176826.111 · Cited by 1,589
Organogenesis and development of the liver
Si-Tayeb, K., Lemaigre, F. P., & Duncan, S. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.011 · Cited by 800
Fox transcription factors: from development to disease
Golson, M. L., & Kaestner, K. H. (2016) · Development · doi:10.1242/dev.112672 · Cited by 406
Self-citationFOXO transcription factor family in cancer and metastasis
Jiramongkol, Y., & Lam, E. W.-F. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09883-w · Cited by 281
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Vernes, S. C., Oliver, P. L., Spiteri, E., Lockstone, H. E., Puliyadi, R., Taylor, J. M., Ho, J., Mombereau, C., Brewer, A., Lowy, E., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002145 · Cited by 276
Metadata
- Authors
- Hannenhalli, S., & Kaestner, K. H.
- Venue
- Nature Reviews Genetics
- Published
- 2009-04
- Volume
- 10
- Issue
- 4
- Pages
- 233-240
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2163107106
- Cited by
- 658
- References
- 91
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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