The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo
Abstract
The Enhancer of split locus is required during many cell-fate decisions in Drosophila, including the segregation of neural precursors in the embryo. We have generated monoclonal antibodies that recognise some of the basic helix-loop-helix proteins encoded by the Enhancer of split locus and have used them to examine expression of Enhancer of split proteins during neurogenesis. The proteins are expressed in a dynamic pattern in the ventral neurogenic region and are confined to those ectodermal cells that surround a neuroblast in the process of delaminating. There is no staining in the neuroblasts themselves. We have also examined the relationship between Enhancer of split protein accumulation and the Notch signalling pathway. Protein expression is abolished in a number of neurogenic mutant backgrounds, including Notch, but is increased as a result of expressing a constitutively active Notch product. We conclude that Notch signalling activity is directly responsible for the accumulation of basic helix-loop-helix proteins encoded by the Enhancer of split locus.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
The Genome of Drosophila Melanogaster
Lindsley, D. L., & Zimm, G. G. (1992) · Cited by 3,098
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,696
N�sslein-Volhard, C., Wieschaus, E., & Kluding, H. (1984) · Wilhelm Roux's Archives of Developmental Biology · doi:10.1007/bf00848156 · Cited by 1,546
Wharton, K. A., Johansen, K. M., Xu, T., & Artavanis-Tsakonas, S. (1985) · Cell · doi:10.1016/0092-8674(85)90229-6 · Cited by 1,060
The choice of cell fate in the epidermis of Drosophila
Heitzler, P., & Simpson, P. (1991) · Cell · doi:10.1016/0092-8674(91)90263-x · Cited by 743
J�rgens, G., Wieschaus, E., N�sslein-Volhard, C., & Kluding, H. (1984) · Wilhelm Roux's Archives of Developmental Biology · doi:10.1007/bf00848157 · Cited by 683
Fehon, R. G., Kooh, P. J., Rebay, I., Regan, C. L., Xu, T., Muskavitch, M. A. T., & Artavanis-Tsakonas, S. (1990) · Cell · doi:10.1016/0092-8674(90)90534-l · Cited by 673
On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster
Lehmann, R., Jim�nez, F., Dietrich, U., & Campos-Ortega, J. A. (1983) · Wilhelm Roux's Archives of Developmental Biology · doi:10.1007/bf00848482 · Cited by 494
Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila.
Chou, T. B., & Perrimon, N. (1992) · Genetics · doi:10.1093/genetics/131.3.643 · Cited by 483
Cited by
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Nuclear Access and Action of Notch In Vivo
Struhl, G., & Adachi, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81193-9 · Cited by 733
Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane
Blaumueller, C. M., Qi, H., Zagouras, P., & Artavanis-Tsakonas, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80336-0 · Cited by 614
Bailey, A. M., & Posakony, J. W. (1995) · Genes & Development · doi:10.1101/gad.9.21.2609 · Cited by 585
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
Kao, H.-Y., Ordentlich, P., Koyano-Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579
Metadata
- Authors
- Jennings, B., Preiss, A., Delidakis, C., & Bray, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-12-01
- Volume
- 120
- Issue
- 12
- Pages
- 3537-3548
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2138301962
- Cited by
- 286
- References
- 57
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. https://app.cochat.ai/papers/10.1242/dev.120.12.3537
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- Jennings, B., Preiss, A., Delidakis, C., & Bray, S. (1994). The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development. https://doi.org/10.1242/dev.120.12.3537
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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