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Cited by 286

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo

Jennings, Barbara, Preiss, Anette, Delidakis, Christos, Bray, Sarah·1994·Development
DOI 10.1242/dev.120.12.3537
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Abstract

The Enhancer of split locus is required during many cell-fate decisions in Drosophila, including the segregation of neural precursors in the embryo. We have generated monoclonal antibodies that recognise some of the basic helix-loop-helix proteins encoded by the Enhancer of split locus and have used them to examine expression of Enhancer of split proteins during neurogenesis. The proteins are expressed in a dynamic pattern in the ventral neurogenic region and are confined to those ectodermal cells that surround a neuroblast in the process of delaminating. There is no staining in the neuroblasts themselves. We have also examined the relationship between Enhancer of split protein accumulation and the Notch signalling pathway. Protein expression is abolished in a number of neurogenic mutant backgrounds, including Notch, but is increased as a result of expressing a constitutively active Notch product. We conclude that Notch signalling activity is directly responsible for the accumulation of basic helix-loop-helix proteins encoded by the Enhancer of split locus.

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Metadata

Authors
Jennings, B., Preiss, A., Delidakis, C., & Bray, S.
Venue
Development
Publisher
The Company of Biologists
Published
1994-12-01
Volume
120
Issue
12
Pages
3537-3548
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.120.12.3537
OpenAlex
W2138301962
Cited by
286
References
57
FWCI
6.25
Type
journal article
Language
en
Open access
closed

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