The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retinoic acid promotes differentiation of photoreceptors in vitro
Abstract
The results of several recent studies have demonstrated that cell commitment and differentiation in the developing vertebrate retina are influenced by cell-cell interactions within the microenvironment. Retinoic acid has been shown to influence cell fates during development of the nervous system, and retinoic acid has been detected in the embryonic retina. To determine whether retinoic acid mediates the differentiation of specific neuronal phenotypes during retinal histogenesis, we treated dissociated cell cultures of embryonic and neonatal rat retina with varying concentrations of all-trans or 9-cis retinoic acid and analyzed the effects on cell fate using neuron and photoreceptor-specific antibodies. Addition of exogenous retinoic acid caused a dose-dependent, specific increase in the number of cells that developed as photoreceptors in culture throughout the period of retinal neurogenesis. In the same cultures, retinoic acid also caused a dose-dependent decrease in the number of cells that developed as amacrine cells. Also, results of double-labeled immunohistochemical studies using bromodeoxyuridine demonstrated that the primary effect of retinoic acid was to influence progenitor cells to develop as newly generated rod photoreceptors. Since retinoic acid and at least one of the retinoic acid receptors (RARα) have been localized to the developing neural retina, these results suggest that retinoic acid may play a role in the normal development of photoreceptor cells in vivo.
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Cites
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992) · Cell · doi:10.1016/0092-8674(92)90479-v · Cited by 1,780
Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S., & Rubin, G. M. (1990) · Cell · doi:10.1016/0092-8674(90)90737-y · Cited by 457
Cited by
Retinal Stem Cells in the Adult Mammalian Eye
Tropepe, V., Coles, B. L. K., Chiasson, B. J., Horsford, D. J., Elia, A. J., McInnes, R. R., & van der Kooy, D. (2000) · Science · doi:10.1126/science.287.5460.2032 · Cited by 1,081
Cell fate determination in the vertebrate retina.
Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M., & Ezzeddine, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.589 · Cited by 986
Functional brain mapping of the relaxation response and meditation
Lazar, S. W., Bush, G., Gollub, R. L., Fricchione, G. L., Khalsa, G., & Benson, H. (2000) · NeuroReport · doi:10.1097/00001756-200005150-00042 · Cited by 717
Genomic Analysis of Mouse Retinal Development
Blackshaw, S., Harpavat, S., Trimarchi, J., Cai, L., Huang, H., Kuo, W. P., Weber, G., Lee, K., Fraioli, R. E., Cho, S.-H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020247 · Cited by 585
Regulation of neurogenesis by growth factors and neurotransmitters
Cameron, H. A., Hazel, T. G., & McKay, R. D. G. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2<287::aid-neu13>3.0.co;2-b · Cited by 494
Metadata
- Authors
- Kelley, M. W., Turner, J. K., & Reh, T. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-08-01
- Volume
- 120
- Issue
- 8
- Pages
- 2091-2102
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2340773711
- Cited by
- 273
- References
- 2
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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