The DOI matches its Crossref record.
Pax-2 controls multiple steps of urogenital development
Open accessAbstract
Urogenital system development in mammals requires the coordinated differentiation of two distinct tissues, the ductal epithelium and the nephrogenic mesenchyme, both derived from the intermediate mesoderm of the early embryo. The former give rise to the genital tracts, ureters and kidney collecting duct system, whereas mesenchymal components undergo epithelial transformation to form nephrons in both the mesonephric (embryonic) and metanephric (definitive) kidney. Pax-2 is a transcriptional regulator of the paired-box family and is widely expressed during the development of both ductal and mesenchymal components of the urogenital system. We report here that Pax-2 homozygous mutant newborn mice lack kidneys, ureters and genital tracts. We attribute these defects to dysgenesis of both ductal and mesenchymal components of the developing urogenital system. The Wolffian and Müllerian ducts, precursors of male and female genital tracts, respectively, develop only partially and degenerate during embryogenesis. The ureters, inducers of the metanephros are absent and therefore kidney development does not take place. Mesenchyme of the nephrogenic cord fails to undergo epithelial transformation and is not able to form tubules in the mesonephros. In addition, we show that the expression of specific markers for each of these components is de-regulated in Pax-2 mutants. These data show that Pax-2 is required for multiple steps during the differentiation of intermediate mesoderm. In addition, Pax-2 mouse mutants provide an animal model for human hereditary kidney diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
Takasato, M., Er, P. X., Becroft, M., Vanslambrouck, J. M., Stanley, E. G., Elefanty, A. G., & Little, M. H. (2014) · Nature Cell Biology · doi:10.1038/ncb2894 · Cited by 720
Sex Determination and Gonadal Development in Mammals
Wilhelm, D., Palmer, S., & Koopman, P. (2007) · Physiological Reviews · doi:10.1152/physrev.00009.2006 · Cited by 686
Drummond, I. A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A. F., Neuhauss, S. C. F., Stemple, D. L., Zwartkruis, F., Rangini, Z., et al. (1998) · Development · doi:10.1242/dev.125.23.4655 · Cited by 486
Sertoli Cells of the Mouse Testis Originate from the Coelomic Epithelium
Karl, J., & Capel, B. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9068 · Cited by 462
Bullock, S. L., Fletcher, J. M., Beddington, R. S. P., & Wilson, V. A. (1998) · Genes & Development · doi:10.1101/gad.12.12.1894 · Cited by 455
Sex Determination and Differentiation
MacLaughlin, D. T., & Donahoe, P. K. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022784 · Cited by 454
Favor, J., Sandulache, R., Neuhäuser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Spörle, R., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13870 · Cited by 391
Celli, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1642 · Cited by 375
Six1 is required for the early organogenesis of mammalian kidney
Xu, P.-X., Zheng, W., Huang, L., Maire, P., Laclef, C., & Silvius, D. (2003) · Development · doi:10.1242/dev.00536 · Cited by 361
Mammalian sex determination: a molecular drama
Swain, A., & Lovell-Badge, R. (1999) · Genes & Development · doi:10.1101/gad.13.7.755 · Cited by 361
Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development
Nishinakamura, R., Matsumoto, Y., Nakao, K., Nakamura, K., Sato, A., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Scully, S., Lacey, D. L., et al. (2001) · Development · doi:10.1242/dev.128.16.3105 · Cited by 358
Grote, D., Souabni, A., Busslinger, M., & Bouchard, M. (2006) · Development · doi:10.1242/dev.02184 · Cited by 351
Ozcan, A., Shen, S. S., Hamilton, C., Anjana, K., Coffey, D., Krishnan, B., & Truong, L. D. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.3 · Cited by 349
Wada, H., Saiga, H., Satoh, N., & Holland, P. W. H. (1998) · Development · doi:10.1242/dev.125.6.1113 · Cited by 312
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
Kispert, A., Vainio, S., Shen, L., Rowitch, D. H., & McMahon, A. P. (1996) · Development · doi:10.1242/dev.122.11.3627 · Cited by 305
Isolation and Characterization of Kidney-Derived Stem Cells
Gupta, S., Verfaillie, C., Chmielewski, D., Kren, S., Eidman, K., Connaire, J., Heremans, Y., Lund, T., Blackstad, M., Jiang, Y., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006030275 · Cited by 286
Kidney morphogenesis: cellular and molecular regulation
Kuure, S., Vuolteenaho, R., & Vainio, S. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00323-8 · Cited by 262
Depew, M. J., Tucker, A. S., & Sharpe, P. T. (2002) · Mouse Development · doi:10.1016/b978-012597951-1/50023-8 · Cited by 259
Patel, S. R., Kim, D., Levitan, I., & Dressler, G. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.09.004 · Cited by 249
Self-citationMolecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
Shang, Y. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1879 · Cited by 246
Vesico-ureteric reflux and urinary tract development in the Pax21Neu+/−mouse
Murawski, I. J., Myburgh, D. B., Favor, J., & Gupta, I. R. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00221.2007 · Cited by 61
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape
Wang, L.-H., Aberin, M. A. E., Wu, S., & Wang, S.-P. (2021) · Biochemical Society Transactions · doi:10.1042/bst20191164 · Cited by 53
Metadata
- Authors
- Torres, M., Gómez-Pardo, E., Dressler, G. R., & Gruss, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-12-01
- Volume
- 121
- Issue
- 12
- Pages
- 4057-4065
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143416290
- Cited by
- 897
- References
- 0
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
