The DOI matches its Crossref record.
Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways
Abstract
The specification of the vertebrate body plan is dependent on numerous signaling molecules, including members of the Wnt family. We have identified two zebrafish wnt8 paralogs related to Xwnt-8B and Xwnt-8, respectively. A RT-PCR assay demonstrated that wnt8 is expressed maternally, with transcripts detected throughout embryogenesis, whereas wnt8b transcripts were first detected during late gastrulation. The wnt8 transcripts at 50% epiboly are spatially restricted to those cells at the blastoderm margin, overlying gsc-expressing cells in the axial hypoblast. During late gastrulation, wnt8 was no longer detected in the marginal cells at the dorsal midline and by mid-segmentation, transcripts were found in the presumptive tail bud. In contrast, wnt8b expression is spatially restricted to prospective neuroepithelium, and later to neural-specific structures. Overexpression of both wnts results in two major phenotypes: radialized embryos and embryos with anterior defects. These phenotypes were preceded by significant changes in the spatial expression patterns of gsc and ntl transcripts, reminiscent of activities of Xwnt-8 in Xenopus, and consistent with a role for wnt8 in the specification or patterning of mesoderm.
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Cited by
Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.81 · Cited by 420
Modulation of Embryonic Intracellular Ca2+Signaling byWnt-5A
Slusarski, D. C., Yang-Snyder, J., Busa, W. B., & Moon, R. T. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8463 · Cited by 404
Self-citationAngers, S., Thorpe, C. J., Biechele, T. L., Goldenberg, S. J., Zheng, N., MacCoss, M. J., & Moon, R. T. (2006) · Nature Cell Biology · doi:10.1038/ncb1381 · Cited by 364
Self-citationLekven, A. C., Thorpe, C. J., Waxman, J. S., & Moon, R. T. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00007-7 · Cited by 349
Self-citationExpression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.
Hoppler, S., Brown, J. D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.21.2805 · Cited by 342
Self-citationPfeffer, P. L., Gerster, T., Lun, K., Brand, M., & Busslinger, M. (1998) · Development · doi:10.1242/dev.125.16.3063 · Cited by 338
Wnt signaling function in Alzheimer’s disease
De Ferrari and, G. V., & Inestrosa, N. C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00021-7 · Cited by 289
Reiterated Wnt signaling during zebrafish neural crest development
Lewis, J. L., Bonner, J., Modrell, M., Ragland, J. W., Moon, R. T., Dorsky, R. I., & Raible, D. W. (2004) · Development · doi:10.1242/dev.01007 · Cited by 263
Self-citationCan zebrafish be used as a model to study the neurodevelopmental causes of autism?
Tropepe, V., & Sive, H. L. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00038.x · Cited by 257
Calcium signaling in vertebrate embryonic patterning and morphogenesis
Slusarski, D. C., & Pelegri, F. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.043 · Cited by 178
Endogenous Wnt Signaling Maintains Neural Progenitor Cell Potency
Wexler, E. M., Paucer, A., Kornblum, H. I., Palmer, T. D., & Geschwind, D. H. (2009) · Stem Cells · doi:10.1002/stem.36 · Cited by 174
nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development
Thorpe, C. J., & Moon, R. T. (2004) · Development · doi:10.1242/dev.01171 · Cited by 84
Self-citationLele, Z., Nowak, M., & Hammerschmidt, M. (2001) · Developmental Dynamics · doi:10.1002/dvdy.1222 · Cited by 55
Metadata
- Authors
- Kelly, G. M., Greenstein, P., Erezyilmaz, D. F., & Moon, R. T.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-06-01
- Volume
- 121
- Issue
- 6
- Pages
- 1787-1799
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2167352593
- Cited by
- 231
- References
- 0
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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