Calcium signaling in vertebrate embryonic patterning and morphogenesis
Open accessAbstract
Signaling pathways that rely on the controlled release and/or accumulation of calcium ions are important in a variety of developmental events in the vertebrate embryo, affecting cell fate specification and morphogenesis. One such major developmentally important pathway is the Wnt/calcium signaling pathway, which, through its antagonism of Wnt/beta-catenin signaling, appears to regulate the formation of the early embryonic organizer. In addition, the Wnt/calcium pathway shares components with another non-canonical Wnt pathway involved in planar cell polarity, suggesting that these two pathways form a loose network involved in polarized cell migratory movements that fashion the vertebrate body plan. Furthermore, left-right axis determination, neural induction and somite formation also display dynamic calcium release, which may be critical in these patterning events. Finally, we summarize recent evidence that propose a role for calcium signaling in stem cell biology and human developmental disorders.
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Wnt5a, Wnt11 and rat Fz2 (RFz-2) are capable of intracellular Ca2+ release, without affecting β-catenin stabilization.
“Wnt5a, Wnt11 and rat Fz2 (RFz-2) are capable of intracellular Ca2+ release, without affecting β-catenin stabilization.91”
From Wnt signal transduction pathways (2008) · cites this paper as [91]
The Wnt/Ca2+ pathway emerged with the finding that some Wnts and Fz receptors can stimulate intracellular Ca2+ release from ER and this pathway is dependent on G-proteins.
“The Wnt/Ca2+ pathway emerged with the finding that some Wnts and Fz receptors can stimulate intracellular Ca2+ release from ER and this pathway is dependent on G-proteins.90,91”
From Wnt signal transduction pathways (2008) · cites this paper as [91]
Wnt5a can activate the non-canonical pathway and induce calcium flux but not activate β-catenin stabilization.
“Likewise, Wnt5a can activate the non-canonical pathway and induce calcium flux but not activate β-catenin stabilization.91,114”
From Wnt signal transduction pathways (2008) · cites this paper as [91]
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Wnt signal transduction pathways
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- Authors
- Slusarski, D. C., & Pelegri, F.
- Affiliations
- University of Iowa (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Pelegri, Francisco
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 307
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC2729314
- OpenAlex
- W2113130311
- Cited by
- 178
- References
- 176
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 11 · 2018: 9 · 2017: 20 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 13
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM065303)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- calcium signaling, vertebrate embryonic development, embryonic patterning, morphogenesis, Wnt/β-catenin signaling, planar cell polarity, cell migration, left-right axis determination, neural induction, somitogenesis, stem cell biology, developmental disorders
- MeSH terms
- Animals, Humans, Morphogenesis, Stem Cells, Vertebrates, Body Patterning, Calcium Signaling, Organizers, Embryonic, Wnt Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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