Cited by 178Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Calcium signaling in vertebrate embryonic patterning and morphogenesis

Open access
Slusarski, Diane C., Pelegri, Francisco·2007·Developmental Biology

Abstract

Signaling pathways that rely on the controlled release and/or accumulation of calcium ions are important in a variety of developmental events in the vertebrate embryo, affecting cell fate specification and morphogenesis. One such major developmentally important pathway is the Wnt/calcium signaling pathway, which, through its antagonism of Wnt/beta-catenin signaling, appears to regulate the formation of the early embryonic organizer. In addition, the Wnt/calcium pathway shares components with another non-canonical Wnt pathway involved in planar cell polarity, suggesting that these two pathways form a loose network involved in polarized cell migratory movements that fashion the vertebrate body plan. Furthermore, left-right axis determination, neural induction and somite formation also display dynamic calcium release, which may be critical in these patterning events. Finally, we summarize recent evidence that propose a role for calcium signaling in stem cell biology and human developmental disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ydbio.2007.04.043

Cites

176 of 176 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Wnt5a, Wnt11 and rat Fz2 (RFz-2) are capable of intracellular Ca2+ release, without affecting β-catenin stabilization.

    “Wnt5a, Wnt11 and rat Fz2 (RFz-2) are capable of intracellular Ca2+ release, without affecting β-catenin stabilization.91”

    From Wnt signal transduction pathways (2008) · cites this paper as [91]

  • The Wnt/Ca2+ pathway emerged with the finding that some Wnts and Fz receptors can stimulate intracellular Ca2+ release from ER and this pathway is dependent on G-proteins.

    “The Wnt/Ca2+ pathway emerged with the finding that some Wnts and Fz receptors can stimulate intracellular Ca2+ release from ER and this pathway is dependent on G-proteins.90,91”

    From Wnt signal transduction pathways (2008) · cites this paper as [91]

  • Wnt5a can activate the non-canonical pathway and induce calcium flux but not activate β-catenin stabilization.

    “Likewise, Wnt5a can activate the non-canonical pathway and induce calcium flux but not activate β-catenin stabilization.91,114”

    From Wnt signal transduction pathways (2008) · cites this paper as [91]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Slusarski, D. C., & Pelegri, F.
Affiliations
  • University of Iowa (US)
  • University of Wisconsin–Madison (US)
Corresponding author
Pelegri, Francisco
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2007-07
Volume
307
Issue
1
Pages
1-13
ISSN
0012-1606 (ISSN-L)
OpenAlex
W2113130311
Cited by
178
References
176
Citations by year
2026: 6 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 11 · 2018: 9 · 2017: 20 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 13
FWCI
0.90
Type
journal article
Language
en
Open access
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (R01GM065303)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
calcium signaling, vertebrate embryonic development, embryonic patterning, morphogenesis, Wnt/β-catenin signaling, planar cell polarity, cell migration, left-right axis determination, neural induction, somitogenesis, stem cell biology, developmental disorders
MeSH terms
Animals, Humans, Morphogenesis, Stem Cells, Vertebrates, Body Patterning, Calcium Signaling, Organizers, Embryonic, Wnt Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review