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A role for the Drosophila Bag-of-marbles protein in the differentiation of cystoblasts from germline stem cells
Abstract
Cell differentiation commonly dictates a change in the cell cycle of mitotic daughters. Previous investigations have suggested that the Drosophila bag of marbles (bam) gene is required for the differentiation of germline stem cell daughters (cystoblasts) from the mother stem cells, perhaps by altering the cell cycle. In this paper, we report the preparation of antibodies to the Bam protein and the use of those reagents to investigate how Bam is required for germ cell development. We find that Bam exists as both a fusome component and as cytoplasmic protein and that cytoplasmic and fusome Bam might have separable activities. We also show that bam mutant germ cells are blocked in differentiation and are trapped as mitotically active cells like stem cells. A model for how Bam might regulate cystocyte differentiation is presented.
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Cited by
Lin, H., & Spradling, A. C. (1997) · Development · doi:10.1242/dev.124.12.2463 · Cited by 698
Xie, T., & Spradling, A. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81424-5 · Cited by 668
Chen, D., & McKearin, D. M. (2003) · Development · doi:10.1242/dev.00325 · Cited by 447
Self-citationSong, X., Wong, M. D., Kawase, E., Xi, R., Ding, B. C., McCarthy, J. J., & Xie, T. (2004) · Development · doi:10.1242/dev.01026 · Cited by 416
RNA LOCALIZATION IN DEVELOPMENT
Bashirullah, A., Cooperstock, R. L., & Lipshitz, H. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.335 · Cited by 339
Type IV collagens regulate BMP signalling in Drosophila
Wang, X., Harris, R. E., Bayston, L. J., & Ashe, H. L. (2008) · Nature · doi:10.1038/nature07214 · Cited by 337
Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis
Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268
Deng, W., & Lin, H. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8669 · Cited by 261
Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage
Zhang, Q., Shalaby, N. A., & Buszczak, M. (2014) · Science · doi:10.1126/science.1246384 · Cited by 192
Blocking promiscuous activation at cryptic promoters directs cell type–specific gene expression
Kim, J., Lu, C., Srinivasan, S., Awe, S., Brehm, A., & Fuller, M. T. (2017) · Science · doi:10.1126/science.aal3096 · Cited by 39
Gui, J., Samuels, T. J., Grobicki, K. Z. A., & Teixeira, F. K. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112181 · Cited by 19
(2025) · doi:10.7554/elife.103828.4
Metadata
- Authors
- McKearin, D., & Ohlstein, B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-09-01
- Volume
- 121
- Issue
- 9
- Pages
- 2937-2947
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2185662616
- Cited by
- 345
- References
- 0
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
