The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors
Abstract
Platelet-derived growth factor alpha-receptors (PDGFRα) are expressed by a subset of neuroepithelial cells in the ventral half of the embryonic day 14 (E14) rat spinal cord. The progeny of these cells subsequently proliferate and migrate into the dorsal parts of the cord after E16. Here, we show that E14 ventral cells are able to generate oligodendrocytes in culture but that dorsal cells acquire this ability only after E16, coinciding with the appearance of PDGFRα-immunoreactive cells in the starting population. PDGFRα-positive cells in optic nerve and spinal cord cultures co-labelled with antibody markers of oligodendrocyte progenitors. When PDGFRα-positive cells were purified from embryonic rat spinal cords by immunoselection and cultured in defined medium, they all differentiated into oligodendrocytes. Very few oligodendrocytes developed in cultures of embryonic spinal cord cells that had been depleted of PDGFRα-expressing cells by antibody-mediated complement lysis. These data demonstrate that all PDGFRα-positive cells in the embryonic rat spinal cord are oligodendrocyte progenitors and that most or all early-developing oligodendrocytes are derived from these ventrally-derived precursors.
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Cell death and control of cell survival in the oligodendrocyte lineage
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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
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Self-citationDefective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice
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Self-citationTakebayashi, H., Yoshida, S., Sugimori, M., Kosako, H., Kominami, R., Nakafuku, M., & Nabeshima, Y.-I. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00466-4 · Cited by 386
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A tripotential glial precursor cell is present in the developing spinal cord
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Self-citationAscl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani, H., Martin, E., Hassani, H., Clavairoly, A., Maire, C. L., Viadieu, A., Kerninon, C., Delmasure, A., Frah, M., Weber, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-13.2013 · Cited by 158
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Metadata
- Authors
- Hall, A., Giese, N. A., & Richardson, W. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-12-01
- Volume
- 122
- Issue
- 12
- Pages
- 4085-4094
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2183343968
- Cited by
- 209
- References
- 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
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