The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio
Abstract
In a screen for embryonic mutants in the zebrafish a large number of mutants were isolated with abnormal brain morphology. We describe here 26 mutants in 13 complementation groups that show abnormal development of large regions of the brain. Early neurogenesis is affected in white tail (wit). During segmentation stages, homozygous wit embryos display an irregularly formed neural keel, particularly in the hindbrain. Using a variety of molecular markers, a severe increase in the number of various early differentiating neurons can be demonstrated. In contrast, late differentiating neurons, radial glial cells and some non-neural cell types, such as the neural crest-derived melanoblasts, are much reduced. Somitogenesis appears delayed. In addition, very reduced numbers of melanophores are present posterior to the mid-trunk. The wit phenotype is reminiscent of neurogenic mutants in Drosophila, such as Notch or Delta. In mutant parachute (pac) embryos the general organization of the hindbrain is disturbed and many rounded cells accumulate loosely in the hindbrain and midbrain ventricles. Mutants in a group of 6 genes, snakehead(snk), natter (nat), otter (ott), fullbrain (ful), viper (vip) and white snake (wis) develop collapsed brain ventricles, before showing signs of general degeneration. atlantis (atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele) mutants have different malformation of the brain folds. Some of them have transient pheno-types, and mutant individuals may grow up to adults.
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Citations
Cites
Organization of hindbrain segments in the zebrafish embryo
Trevarrow, B., Marks, D. L., & Kimmel, C. B. (1990) · Neuron · doi:10.1016/0896-6273(90)90194-k · Cited by 506
Zebrafish pigmentation mutations and the processes of neural crest development
Kelsh, R. N., Brand, M., Jiang, Y.-J., Heisenberg, C.-P., Lin, S., Haffter, P., Odenthal, J., Mullins, M. C., Eeden, F. J. M. V., Furutani-Seiki, M., et al. (1996) · Development · doi:10.1242/dev.123.1.369 · Cited by 455
Self-citationVenstrom, K. A., & Reichardt, L. F. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.11.8370483 · Cited by 269
Cited by
Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi110 · Cited by 1,374
Lawson, N. D., Scheer, N., Pham, V. N., Kim, C.-H., Chitnis, A. B., Campos-Ortega, J. A., & Weinstein, B. M. (2001) · Development · doi:10.1242/dev.128.19.3675 · Cited by 915
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497
Zebrafish pigmentation mutations and the processes of neural crest development
Kelsh, R. N., Brand, M., Jiang, Y.-J., Heisenberg, C.-P., Lin, S., Haffter, P., Odenthal, J., Mullins, M. C., Eeden, F. J. M. V., Furutani-Seiki, M., et al. (1996) · Development · doi:10.1242/dev.123.1.369 · Cited by 455
Self-citationHematopoietic stem cell fate is established by the Notch-Runx pathway
Burns, C. E., Traver, D., Mayhall, E., Shepard, J. L., & Zon, L. I. (2005) · Genes & Development · doi:10.1101/gad.1337005 · Cited by 401
Mutations affecting pigmentation and shape of the adult zebrafish.
Haffter, P., Odenthal, J., Mullins, M. C., Lin, S., Farrell, M. J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F. J. M., Furutani-Seiki, M., et al. (1996) · Development Genes and Evolution · doi:10.1007/s004270050051 · Cited by 175
Self-citationLászló, Z. I., & Lele, Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.972059 · Cited by 49
Metadata
- Authors
- Jiang, Y.-J., Brand, M., Heisenberg, C.-P., Beuchle, D., Furutani-Seiki, M., Kelsh, R. N., Warga, R. M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Mullins, M. C., Odenthal, J., Eeden, F. J. M. V., & Nüsslein-Volhard, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-12-01
- Volume
- 123
- Issue
- 1
- Pages
- 205-216
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2165936034
- Cited by
- 298
- References
- 3
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- closed
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