The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mutations affecting the cardiovascular system and other internal organs in zebrafish
Abstract
In a screen for early developmental mutants of the zebrafish, we have identified mutations specifically affecting the internal organs. We identified 53 mutations affecting the cardiovascular system. Nine of them affect specific landmarks of heart morphogenesis. Mutations in four genes cause a failure in the fusion of the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, no heart venticle is visible and the atrium is directly fused to the outflow tract. In the overlooped mutant, the relative position of the two heart chambers is distorted. The heart is enormously enlarged in the santa mutant. In two mutants, scotch tape and superglue, the cardiac jelly between the two layers of the heart is significantly reduced. We also identified a number of mutations affecting the function of the heart. The mutations affecting heart function can be subdivided into two groups, one affecting heart contraction and another affecting the rhythm of the heart beat. Among the contractility group of mutants are 5 with no heart beat at all and 15 with a reduced heart beat of one or both chambers. 6 mutations are in the rhythmicity group and specifically affect the beating pattern of the heart. Mutations in two genes, bypass and kurzschluss, cause specific defects in the circulatory system. In addition to the heart mutants, we identified 23 mutations affecting the integrity of the liver, the intestine or the kidney. In this report, we demonstrate that it is feasible to screen for genes specific for the patterning or function of certain internal organs in the zebrafish. The mutations presented here could serve as an entrypoint to the establishment of a genetic hierarchy underlying organogenesis.
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Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606
Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F., & Copeland, N. G. (1994) · Genes & Development · doi:10.1101/gad.8.9.1019 · Cited by 641
Structural development of endocardial cushions
Markwald, R. R., Fitzharris, T. P., & Manasek, F. J. (1977) · American Journal of Anatomy · doi:10.1002/aja.1001480108 · Cited by 489
Cited by
Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi110 · Cited by 1,374
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Moreno-Mateos, M. A., Vejnar, C. E., Beaudoin, J.-D., Fernandez, J. P., Mis, E. K., Khokha, M. K., & Giraldez, A. J. (2015) · Nature Methods · doi:10.1038/nmeth.3543 · Cited by 1,290
Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
Stainier, D. Y. R., Fouquet, B., Chen, J.-N., Warren, K. S., Weinstein, B. M., Meiler, S. E., Mohideen, M.-A. P. K., Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A. F., et al. (1996) · Development · doi:10.1242/dev.123.1.285 · Cited by 624
Self-citationDrummond, I. A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A. F., Neuhauss, S. C. F., Stemple, D. L., Zwartkruis, F., Rangini, Z., et al. (1998) · Development · doi:10.1242/dev.125.23.4655 · Cited by 486
Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414
Arterial–Venous Specification During Development
Swift, M. R., & Weinstein, B. M. (2009) · Circulation Research · doi:10.1161/circresaha.108.188805 · Cited by 420
Unique and conserved aspects of gut development in zebrafish
Wallace, K. N., & Pack, M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00034-9 · Cited by 349
The Zebrafish as a Model Organism to Study Development of the Immune System
TRAVER, D., HERBOMEL, P., PATTON, E. E., MURPHEY, R. D., YODER, J. A., LITMAN, G. W., CATIC, A., AMEMIYA, C. T., ZON, L. I., & TREDE, N. S. (2003) · Advances in Immunology · doi:10.1016/s0065-2776(03)81007-6 · Cited by 276
Komada, M., & Soriano, P. (1999) · Genes & Development · doi:10.1101/gad.13.11.1475 · Cited by 209
Mutations affecting pigmentation and shape of the adult zebrafish.
Haffter, P., Odenthal, J., Mullins, M. C., Lin, S., Farrell, M. J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F. J. M., Furutani-Seiki, M., et al. (1996) · Development Genes and Evolution · doi:10.1007/s004270050051 · Cited by 175
Self-citationNotochord Patterning of the Endoderm
Cleaver, O., & Krieg, P. A. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0214 · Cited by 114
Poulain, M., & Lepage, T. (2002) · Development · doi:10.1242/dev.129.21.4901 · Cited by 96
Scherer, A. K., Blair, B. A., Park, J., Seman, B. G., Kelley, J. B., & Wheeler, R. T. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008414 · Cited by 30
Metadata
- Authors
- Chen, J.-N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.-P., Jiang, Y.-J., Kane, D. A., Kelsh, R. N., Mullins, M. C., & Nüsslein-Volhard, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-12-01
- Volume
- 123
- Issue
- 1
- Pages
- 293-302
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2148335222
- Cited by
- 444
- References
- 4
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- closed
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