The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish
Open accessAbstract
One of the major challenges of developmental biology is understanding the inductive and morphogenetic processes that shape the vertebrate embryo. In a large-scale genetic screen for zygotic effect, embryonic lethal mutations in zebrafish we have identified 25 mutations that affect specification of cell fates and/or cellular rearrangements during gastrulation. These mutations define at least 14 complementation groups, four of which correspond to previously identified genes. Phenotypic analysis of the ten novel loci revealed three groups of mutations causing distinct effects on cell fates in the gastrula. One group comprises mutations that lead to deficiencies in dorsal mesodermal fates and affect central nervous system patterning. Mutations from the second group affect formation of ventroposterior embryonic structures. We suggest that mutations in these two groups identify genes necessary for the formation, maintenance or function of the dorsal organizer and the ventral signaling pathway, respectively. Mutations in the third group affect primarily cellular rearrangements during gastrulation and have complex effects on cell fates in the embryo. This group, and to some extent mutations from the first two groups, affect the major morphogenetic processes, epiboly, convergence and extension, and tail morphogenesis. These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465
Halpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., & Kimmel, C. B. (1995) · Development · doi:10.1242/dev.121.12.4257 · Cited by 178
Cited by
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013
Self-citationWallingford, J. B., Fraser, S. E., & Harland, R. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00197-1 · Cited by 613
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Jessen, J. R., Topczewski, J., Bingham, S., Sepich, D. S., Marlow, F., Chandrasekhar, A., & Solnica-Krezel, L. (2002) · Nature Cell Biology · doi:10.1038/ncb828 · Cited by 504
Self-citationTopczewski, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., & Solnica-Krezel, L. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00005-3 · Cited by 455
Self-citationConserved Patterns of Cell Movements during Vertebrate Gastrulation
Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391
Self-citationSchier, A. F., Neuhauss, S. C. F., Helde, K. A., Talbot, W. S., & Driever, W. (1997) · Development · doi:10.1242/dev.124.2.327 · Cited by 359
Self-citationNotochord induction of zebrafish slow muscle mediated by Sonic hedgehog
Blagden, C. S., Currie, P. D., Ingham, P. W., & Hughes, S. M. (1997) · Genes & Development · doi:10.1101/gad.11.17.2163 · Cited by 357
Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
Carreira-Barbosa, F., Concha, M. L., Takeuchi, M., Ueno, N., Wilson, S. W., & Tada, M. (2003) · Development · doi:10.1242/dev.00567 · Cited by 269
Patterning the zebrafish axial skeleton requires early chordin function
Fisher, S., & Halpern, M. E. (1999) · Nature Genetics · doi:10.1038/70557 · Cited by 102
The Tumor Suppressor PRDM5 Regulates Wnt Signaling at Early Stages of Zebrafish Development
Meani, N., Pezzimenti, F., Deflorian, G., Mione, M., & Alcalay, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004273 · Cited by 47
A genetically tractable non-vertebrate system to study complete camera-type eye regeneration
Accorsi, A., Pardo, B., Ross, E., Corbin, T. J., McClain, M., Weaver, K., Delventhal, K., Gattamraju, A., Morrison, J. A., McKinney, M. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61681-6 · Cited by 14
Metadata
- Authors
- Solnica-Krezel, L., Stemple, D. L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S. C. F., Malicki, J., Schier, A. F., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S., & Driever, W.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-12-01
- Volume
- 123
- Issue
- 1
- Pages
- 67-80
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1811130017
- Cited by
- 320
- References
- 3
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
