The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode
Abstract
We have identified and mapped three members of a new family of vertebrate genes, designated Eya1, Eya2 and Eya3, which share high sequence similarity with the Drosophila eyes absent (eya) gene. Comparison of all three murine Eya gene products and that encoded by the Drosophila eya gene defines a 271 amino acid carboxyl terminal Eya domain, which has been highly conserved during evolution. Eya1 and Eya2, which are closely related, are extensively expressed in cranial placodes, in the branchial arches and CNS and in complementary or over-lapping patterns during organogenesis. Eya3 is also expressed in the branchial arches and CNS, but lacks cranial placode expression. All three Eya genes are expressed in the developing eye. Eya1 is expressed in developing anterior chamber structures, including the lens placode, the iris and ciliary region and the prospective corneal ectoderm. Eya1 is also expressed in retinal pigment epithelium and optic nerve. Eya2 is expressed in neural retina, sclera and optic nerve sheath. Moreover, Eya1 and Eya2 expressions in the lens and nasal placode overlap with and depend upon expression of Pax6. The high sequence similarity with Drosophila eya, the conserved developmental expression of Eya genes in the eye and the Pax6 dependence of Eya expression in the lens and nasal placode indicates that these genes likely represent functional homologues of the Drosophila eya gene. These results suggest that members of the Eya gene family play critical roles down-stream of Pax genes in specifying placodal identity and support the idea that despite enormous morphological differences, the early development of insect and mammalian eyes is controlled by a conserved regulatory hierarchy.
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Cites
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Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene
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Pax-6, a murine paired box gene, is expressed in the developing CNS
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Mouse Small eye results from mutations in a paired-like homeobox-containing gene
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Self-citationContributions of placodal and neural crest cells to avian cranial peripheral ganglia
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The role of Pax-6 in eye and nasal development
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Early animal evolution: emerging views from comparative biology and geology
Knoll, A. H., & Carroll, S. B. (1999) · Science · doi:10.1126/science.284.5423.2129 · Cited by 821
Six1 is required for the early organogenesis of mammalian kidney
Xu, P.-X., Zheng, W., Huang, L., Maire, P., Laclef, C., & Silvius, D. (2003) · Development · doi:10.1242/dev.00536 · Cited by 361
Self-citationSix3 overexpression initiates the formation of ectopic retina
Loosli, F., Winkler, S., & Wittbrodt, J. (1999) · Genes & Development · doi:10.1101/gad.13.6.649 · Cited by 257
Global expression analysis of gene regulatory pathways during endocrine pancreatic development
Gu, G., Wells, J. M., Dombkowski, D., Preffer, F., Aronow, B., & Melton, D. A. (2004) · Development · doi:10.1242/dev.00921 · Cited by 229
Regulation of mouse lens fiber cell development and differentiation by the Maf gene
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Gene sharing in lens and cornea: facts and implications
Piatigorsky, J. (1998) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(97)00004-9 · Cited by 159
Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism
Masumoto, K.-H., Ukai-Tadenuma, M., Kasukawa, T., Nagano, M., Uno, K. D., Tsujino, K., Horikawa, K., Shigeyoshi, Y., & Ueda, H. R. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.038 · Cited by 118
Metadata
- Authors
- Xu, P.-X., Woo, I., Her, H., Beier, D. R., & Maas, R. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-01-01
- Volume
- 124
- Issue
- 1
- Pages
- 219-231
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2117439162
- Cited by
- 331
- References
- 44
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
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