Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 709

The DOI matches its Crossref record.

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Furuta, Yasuhide, Piston, David W., Hogan, Brigid L. M.·1997·Development
DOI 10.1242/dev.124.11.2203
Open this paper in CoChat — free account

Abstract

Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of developmental processes, but their functions during early vertebrate brain development are largely unknown. To investigate this problem, we have compared by in situ hybridization the expression of fiveBmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7). Striking co-expression of theseBmps is observed within the dorsomedial telencephalon, coincident with a future site of choroid plexus development. Bmp co-expression overlaps that of Msx1 and Hfh4, and is complementary to that of Bf1. The domain of Bmp co-expression is also associated with limited growth of the neuroectoderm, as revealed by morphological observation, reduced cell proliferation, and increased local programmed cell death. In vitro experiments using explants from the embryonic lateral telencephalic neuroectoderm reveal that exogenous BMP proteins (BMP4 and BMP2) induce expression ofMsx1 and inhibit Bf1 expression, a finding consistent with their specific expression patterns in vivo. Moreover, BMP proteins locally inhibit cell proliferation and increase apoptosis in the explants. These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1242/dev.124.11.2203

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 40

  1. Barlow, 1997, Ectopic application of recombinant BMP2 and BMP4 can change patterning of developing chick facial primordia, Development, 124, 391, 10.1242/dev.124.2.391 · DOI · Paper page
  2. Brunelli, 1996, Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly, Nature Genet, 12, 94, 10.1038/ng0196-94 · DOI · Paper page
  3. Chiang, 1996, Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function, Nature, 383, 407, 10.1038/383407a0 · DOI · Paper page
  4. Davidson, 1995, The function and evolution of Msx genes: pointers and paradoxes, Trends Genet, 11, 405, 10.1016/S0168-9525(00)89124-6 · DOI · Paper page
  5. Dewulf, 1995, Distinct spatial and temporal expression patterns of two type I Receptors for bone morphogenetic proteins during mouse embryogenesis, Endocrinology, 136, 2652, 10.1210/endo.136.6.7750489 · doi:10.1210/endo.136.6.7750489 · Paper page
  6. Dudley, 1995, A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye, Genes Dev, 9, 2795, 10.1101/gad.9.22.2795 · DOI · Paper page
  7. Ericson, 1995, Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube, Cell, 81, 747, 10.1016/0092-8674(95)90536-7 · DOI · Paper page
  8. Ganan, 1996, Role of TGFβ and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the chick limb autopod, Development, 122, 2349, 10.1242/dev.122.8.2349 · DOI · Paper page
  9. Gavrieli, 1992, Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J. Cell Biol, 119, 493, 10.1083/jcb.119.3.493 · DOI · Paper page
  10. Graham, 1994, The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest, Nature, 372, 684, 10.1038/372684a0 · DOI · Paper page
  11. Gross, 1996, Bone Morphogenetic Proteins promote astroglyal lineage commitment by mammalian subventricular zone progenitor cells, Neuron, 17, 595, 10.1016/S0896-6273(00)80193-2 · DOI · Paper page
  12. Hill, 1989, A new family of mouse homeobox-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1, Genes Dev, 3, 26, 10.1101/gad.3.1.26 · DOI · Paper page
  13. Hogan, 1994, Manipulating the Mouse Embryos
  14. Hogan, 1996, Bone morphogenetic proteins: multifunctional regulators of embryonic development, Genes Dev, 10, 1580, 10.1101/gad.10.13.1580 · DOI · Paper page
  15. Jones, 1991, Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse, Development, 111, 531, 10.1242/dev.111.2.531 · DOI · Paper page
  16. Joyner, 1996, Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development, Trends Genet, 12, 15, 10.1016/0168-9525(96)81383-7 · DOI · Paper page
  17. King, 1994, BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice, 10.1006/dbio.1994.1300 · DOI · Paper page
  18. Kingsley, 1994, The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms, Genes Dev, 8, 133, 10.1101/gad.8.2.133 · DOI · Paper page
  19. Liem, 1995, Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm, Cell, 82, 969, 10.1016/0092-8674(95)90276-7 · DOI · Paper page
  20. Lim, 1997, The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo, 10.1073/pnas.94.7.3094 · DOI
  21. Lumsden, 1996, Patterning the vertebrate neuraxis, Science, 274, 1109, 10.1126/science.274.5290.1109 · DOI · Paper page
  22. Luo, 1995, BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning, Genes Dev, 9, 2808, 10.1101/gad.9.22.2808 · DOI · Paper page
  23. Lyons, 1989, Patterns of expression of murine Vgr-1 and BMP-2a suggest that TGFß-like genes coordinately regulate aspects of embryonic development, Genes Dev, 3, 1657, 10.1101/gad.3.11.1657 · DOI · Paper page
  24. Lyons, 1995, Colocalization of BMP7 and BMP2 RNAs suggest that these factors cooperatively mediate tissue interactions during murine development, Mech. Dev, 50, 71, 10.1016/0925-4773(94)00326-I · DOI · Paper page
  25. Macdonald, 1995, Midline signal is required for Pax gene regulation and patterning of the eyes, Development, 121, 3267, 10.1242/dev.121.10.3267 · DOI · Paper page
  26. Matsuo, 1995, Mouse Otx2 functions in the formation and patterning of rostral head, Genes Dev, 9, 2646, 10.1101/gad.9.21.2646 · DOI · Paper page
  27. Netsky, 1975, The Choroid Plexus in Health and Disease
  28. Osumi-Yamashita, 1994, The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos, Dev. Biol, 164, 409, 10.1006/dbio.1994.1211 · DOI · Paper page
  29. Pellegrini, 1996, Dentate gyrus formation requires Emx2, Development, 122, 3893, 10.1242/dev.122.12.3893 · DOI · Paper page
  30. Qiu, 1996, Mutation of the Emx-1 homeobox gene disrupts the corpus callosum, Dev. Biol, 178, 174, 10.1006/dbio.1996.0207 · DOI
  31. Rubenstein, 1994, The embryonic vertebrate forebrain: The prosomeric model, Science, 266, 578, 10.1126/science.7939711 · DOI · Paper page
  32. Shimeld, 1996, The murine homeobox gene Msx-3 shows highly restricted expression in the developing neural tube, Mech. Dev, 55, 201, 10.1016/0925-4773(96)00505-9 · DOI
  33. Tao, 1992, Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family in the developing rat brain, Neuron, 8, 957, 10.1016/0896-6273(92)90210-5 · DOI · Paper page
  34. Thomas, 1993, Capacity to form choroid plexus-like cells in vitro is restricted to specific regions of the mouse neural ectoderm, Development, 117, 253, 10.1242/dev.117.1.253 · DOI
  35. Vainio, 1993, Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development, Cell, 75, 45, 10.1016/S0092-8674(05)80083-2 · doi:10.1016/s0092-8674(05)80083-2 · Paper page
  36. Winnier, 1995, Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse, Genes Dev, 9, 2105, 10.1101/gad.9.17.2105 · DOI · Paper page
  37. Xuan, 1995, Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres, Neuron, 14, 1141, 10.1016/0896-6273(95)90262-7 · DOI · Paper page
  38. Yoshida, 1997, Emx1 and Emx2 functions in development of dorsal telencephalon, Development, 124, 101, 10.1242/dev.124.1.101 · DOI · Paper page
  39. Zhang, 1996, Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development, Development, 122, 2977, 10.1242/dev.122.10.2977 · DOI · Paper page
  40. Zou, 1996, Requirement for BMP signaling in interdigital apoptosis and scale formation, Science, 272, 738, 10.1126/science.272.5262.738 · DOI · Paper page

Cited by

See all 709

Metadata

Authors
Furuta, Y., Piston, D. W., & Hogan, B. L. M.
Venue
Development
Publisher
The Company of Biologists
Published
1997-06-01
Volume
124
Issue
11
Pages
2203-2212
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.124.11.2203
OpenAlex
W2115438940
Cited by
709
References
0
FWCI
9.56
Type
journal article
Language
en
Open access
closed
Licence
www.biologists.com/user-licence-1-1/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. https://app.cochat.ai/papers/10.1242/dev.124.11.2203
The paper
Furuta, Y., Piston, D. W., & Hogan, B. L. M. (1997). Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. https://doi.org/10.1242/dev.124.11.2203

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.