Cited by 734Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Forebrain gene expression domains and the evolving prosomeric model

Puelles, Luis, Rubenstein, John L.R.·2003·Trends in Neurosciences

Abstract

The prosomeric model attributes morphological meaning to gene expression patterns and other data in the forebrain. It divides this territory into the same transverse segments (prosomeres) and longitudinal zones in all vertebrates. The axis and longitudinal zones of this model are widely accepted but controversy subsists about the number of prosomeres and their nature as segments. We describe difficulties encountered in establishing continuity between prosomeric limits postulated in the hypothalamus and intra-telencephalic limits. Such difficulties throw doubt on the intersegmental nature of these limits. We sketch a simplified model, in which the secondary prosencephalon (telencephalon plus hypothalamus) is a complex protosegment not subdivided into prosomeres, which exhibits patterning singularities. By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain.

Integrity signals

Registry

Crossref · 10.1016/s0166-2236(03)00234-0

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Phylogenetically, some of the oldest cortical regions lie on the inferior brain surface in the medial aspect of the temporal lobe (posterior piriform cortex and entorhinal cortex) or on the inferior and medial aspect of the frontal lobe near the caudal end of the olfactory sulcus (anterior piriform cortex and orbital periallocortex).

    “Phylogenetically, some of the oldest cortical regions lie on the inferior brain surface in the medial aspect of the temporal lobe (the posterior part of the piriform cortex and the entorhinal cortex, for example) or on the inferior and medial aspect of the frontal lobe near the caudal end of the olfactory sulcus (anterior piriform cortex and the orbital periallocortex) (35–37).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Puelles, L., & Rubenstein, J. L. R.
Affiliations
  • Universidad de Murcia (ES)
  • University of California, San Francisco (US)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2003-09
Volume
26
Issue
9
Pages
469-476
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2083404062
Cited by
734
References
71
Citations by year
2026: 12 · 2025: 16 · 2024: 17 · 2023: 18 · 2022: 28 · 2021: 30 · 2020: 29 · 2019: 27 · 2018: 24 · 2017: 21 · 2016: 44 · 2015: 40 · 2014: 40 · 2013: 42 · 2012: 43
FWCI
2.17
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2k02mh001046-06)
  • National Institute of Mental Health (K02MH01046)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
prosomeric model, forebrain development, gene expression domains, hypothalamus, telencephalon, thalamus, prethalamus, pretectum
MeSH terms
Animals, Humans, Hypothalamus, Models, Neurological, Telencephalon, Gene Expression, Prosencephalon

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review