The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus
Abstract
The marginal zone is a ring of tissue that gives rise to a characteristic dorsoventral pattern of mesoderm in amphibian embryos. Bmp-4 is thought to play an important role in specifying ventral mesodermal fate. Here we show (1)that different doses of Bmp-4 are sufficient to pattern four distinct mesodermal cell types and to pattern gene expression in the early gastrula marginal zone into three domains, (2) that there is a graded requirement for a Bmp signal in mesodermal patterning, and (3) that Bmp-4 has long-range activity which can become graded in the marginal zone by the antagonizing action of noggin. The results argue that Bmp-4 acts as a morphogen in dorsoventral patterning of mesoderm.
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Cites
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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
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R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis
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Metadata
- Authors
- Dosch, R., Gawantka, V., Delius, H., Blumenstock, C., & Niehrs, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-06-15
- Volume
- 124
- Issue
- 12
- Pages
- 2325-2334
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1946465460
- Cited by
- 335
- References
- 85
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- closed
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