The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development
Abstract
We investigated the function of Lhx2, a LIM homeobox gene expressed in developing B-cells, forebrain and neural retina, by analyzing embryos deficient in functional Lhx2 protein. Lhx2 mutant embryos are anophthalmic, have malformations of the cerebral cortex, and die in utero due to severe anemia. In Lhx2−/− embryos specification of the optic vesicle occurs; however, development of the eye arrests prior to formation of an optic cup. Deficient cellular proliferation in the forebrain results in hypoplasia of the neocortex and aplasia of the hippocampal anlagen. In addition to the central nervous system malformations, a cell non-autonomous defect of definitive erythropoiesis causes severe anemia in Lhx2−/− embryos. Thus Lhx2 is necessary for normal development of the eye, cerebral cortex, and efficient definitive erythropoiesis.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
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LEUSSIS, M., & BOLIVAR, V (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.03.006 · Cited by 330
Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate
Mangale, V. S., Hirokawa, K. E., Satyaki, P. R. V., Gokulchandran, N., Chikbire, S., Subramanian, L., Shetty, A. S., Martynoga, B., Paul, J., Mai, M. V., et al. (2008) · Science · doi:10.1126/science.1151695 · Cited by 316
Single-Cell Transcriptional Analysis of Neuronal Progenitors
Tietjen, I., Rihel, J. M., Cao, Y., Koentges, G., Zakhary, L., & Dulac, C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00229-0 · Cited by 260
The cellular and molecular mechanisms of vertebrate lens development
Cvekl, A., & Ashery-Padan, R. (2014) · Development · doi:10.1242/dev.107953 · Cited by 227
Metadata
- Authors
- Porter, F. D., Drago, J., Xu, Y., Cheema, S. S., Wassif, C., Huang, S.-P., Lee, E., Grinberg, A., Massalas, J. S., Bodine, D., Alt, F., & Westphal, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-08-01
- Volume
- 124
- Issue
- 15
- Pages
- 2935-2944
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2120288525
- Cited by
- 491
- References
- 2
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Porter, F. D., Drago, J., Xu, Y., Cheema, S. S., Wassif, C., Huang, S.-P., Lee, E., Grinberg, A., Massalas, J. S., Bodine, D., Alt, F., & Westphal, H. (1997). Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. https://doi.org/10.1242/dev.124.15.2935
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