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Cited by 417

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing

Neumann, Carl J., Cohen, Stephen M.·1997·Development

Abstract

Short-range interaction between dorsal and ventral (D and V) cells establishes an organizing center at the DV compartment boundary that controls growth and specifies cell fate along the dorsal-ventral axis of the Drosophila wing. The secreted signaling molecule Wingless (Wg) is expressed by cells at the DV compartment boundary and has been implicated in mediating its long-range patterning activities. Here we show that Wg acts directly, at long range, to define the expression domains of its target genes, Distal-less and vestigial. Expression of the Achaete-scute genes, Distal-less and vestigial at different distances from the DV boundary is controlled by Wg in a concentration-dependent manner. We propose that Wg acts as a morphogen in patterning the D/V axis of the wing.

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Crossref · 10.1242/dev.124.4.871

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Metadata

Authors
Neumann, C. J., & Cohen, S. M.
Venue
Development
Published
1997-02-15
Volume
124
Issue
4
Pages
871-880
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2124955351
Cited by
417
References
1
FWCI
9.79
Type
journal article
Language
en
Open access
closed

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