The DOI matches its Crossref record.
Neural crest induction in Xenopus: evidence for a two-signal model
Abstract
We have investigated the molecular interactions underlying neural crest formation in Xenopus. Using chordin overexpression to antagonize endogenous BMP signaling in whole embryos and explants, we demonstrate that such inhibition alone is insufficient to account for neural crest induction in vivo. We find, however, that chordin-induced neural plate tissue can be induced to adopt neural crest fates by members of the FGF and Wnt families, growth factors that have previously been shown to posteriorize induced neural tissue. Overexpression of a dominant negative XWnt-8 inhibits the expression of neural crest markers, demonstrating the necessity for a Wnt signal during neural crest induction in vivo. The requirement for Wnt signaling during neural crest induction is shown to be direct, whereas FGF-mediated neural crest induction may be mediated by Wnt signals. Overexpression of the zinc finger transcription factor Slug, one of the earliest markers of neural crest formation, is insufficient for neural crest induction. Slug-expressing ectoderm will generate neural crest in the presence of Wnt or FGF-like signals, however, bypassing the need for BMP inhibition in this process. A two-step model for neural crest induction is proposed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The snail superfamily of zinc-finger transcription factors
Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719
LDL-receptor-related proteins in Wnt signal transduction
Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y., Hess, F., Saint-Jeannet, J.-P., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,128
Neural crest development is regulated by the transcription factor Sox9
Cheung, M., & Briscoe, J. (2003) · Development · doi:10.1242/dev.00808 · Cited by 482
Wise, a context-dependent activator and inhibitor of Wnt signalling
Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321
The transcription factor Sox9 is required for cranial neural crest development in Xenopus
Spokony, R. F., Aoki, Y., Saint-Germain, N., Magner-Fink, E., & Saint-Jeannet, J.-P. (2002) · Development · doi:10.1242/dev.129.2.421 · Cited by 295
Depew, M. J., Tucker, A. S., & Sharpe, P. T. (2002) · Mouse Development · doi:10.1016/b978-012597951-1/50023-8 · Cited by 259
lockjaw encodes a zebrafish tfap2a required for early neural crest development
Knight, R. D., Nair, S., Nelson, S. S., Afshar, A., Javidan, Y., Geisler, R., Rauch, G.-J., & Schilling, T. F. (2003) · Development · doi:10.1242/dev.00575 · Cited by 186
Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network
de Crozé, N., Maczkowiak, F., & Monsoro-Burq, A. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010740107 · Cited by 166
Li, B., Kuriyama, S., Moreno, M., & Mayor, R. (2009) · Development · doi:10.1242/dev.036954 · Cited by 149
Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population
Wang, W.-D., Melville, D. B., Montero-Balaguer, M., Hatzopoulos, A. K., & Knapik, E. W. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.09.019 · Cited by 99
Montero‐Balaguer, M., Lang, M. R., Sachdev, S. W., Knappmeyer, C., Stewart, R. A., De La Guardia, A., Hatzopoulos, A. K., & Knapik, E. W. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20959 · Cited by 95
Insights From a Sea Lamprey Into the Evolution of Neural Crest Gene Regulatory Network
Sauka-Spengler, T., & Bronner-Fraser, M. (2008) · The Biological Bulletin · doi:10.2307/25470671 · Cited by 55
Self-citation
Metadata
- Authors
- LaBonne, C., & Bronner-Fraser, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-07-01
- Volume
- 125
- Issue
- 13
- Pages
- 2403-2414
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2158071345
- Cited by
- 490
- References
- 0
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
