The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs
Abstract
Prx1 and Prx2 are closely related paired-class homeobox genes that are expressed in very similar patterns predominantly in mesenchyme. Prx1 loss-of-function mutants show skeletal defects in skull, limbs and vertebral column (Martin, J. F., Bradley, A. and Olson, E. N. (1995) Genes Dev. 9, 1237-1249). We report here that mice in which Prx2 is inactivated by a lacZ insertion had no skeletal defects, whereas Prx1/Prx2 double mutants showed many novel abnormalities in addition to an aggravation of the Prx1 single mutant phenotype. We found defects in external, middle and inner ear, reduction or loss of skull bones, a reduced and sometimes cleft mandible, and limb abnormalities including postaxial polydactyly and bent zeugopods. A single, or no incisor was present in the lower jaw, and ectopic expression of Fgf8 and Pax9 was found medially in the mandibular arch. A novel method to detect β-galactosidase activity in hydroxyethylmethacrylate sections allowed detailed analysis of Prx2 expression in affected structures. Our results suggest a role for Prx genes in mediating epitheliomesenchymal interactions in inner ear and lower jaw. In addition, Prx1 and Prx2 are involved in interactions between perichondrium and chondrocytes that regulate their proliferation or differentiation in the bones of the zeugopods.
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Cites
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Regulatory divergence modifies limb length between mammals
Cretekos, C. J., Wang, Y., Green, E. D., Program, N. C. S., Martin, J. F., Rasweiler, J. J., & Behringer, R. R. (2008) · Genes & Development · doi:10.1101/gad.1620408 · Cited by 232
Self-citationThe development of the mammalian outer and middle ear
Anthwal, N., & Thompson, H. (2016) · Journal of Anatomy · doi:10.1111/joa.12344 · Cited by 197
Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice
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Metadata
- Authors
- ten Berge, D., Brouwer, A., Korving, J., Martin, J. F., & Meijlink, F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-10-01
- Volume
- 125
- Issue
- 19
- Pages
- 3831-3842
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1951644352
- Cited by
- 273
- References
- 27
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- ten Berge, D., Brouwer, A., Korving, J., Martin, J. F., & Meijlink, F. (1998). Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs. Development. https://doi.org/10.1242/dev.125.19.3831
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