The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Requirement of the MADS-box transcription factor MEF2C for vascular development
Abstract
The embryonic vasculature develops from endothelial cells that form a primitive vascular plexus which recruits smooth muscle cells to form the arterial and venous systems. The MADS-box transcription factor MEF2C is expressed in developing endothelial cells and smooth muscle cells (SMCs), as well as in surrounding mesenchyme, during embryogenesis. Targeted deletion of the mouse MEF2C gene resulted in severe vascular abnormalities and lethality in homozygous mutants by embryonic day 9.5. Endothelial cells were present and were able to differentiate, but failed to organize normally into a vascular plexus, and smooth muscle cells did not differentiate in MEF2C mutant embryos. These vascular defects resemble those in mice lacking the vascular-specific endothelial cell growth factor VEGF or its receptor Flt-1, both of which are expressed in MEF2C mutant embryos. These results reveal multiple roles for MEF2C in vascular development and suggest that MEF2-dependent target genes mediate endothelial cell organization and SMC differentiation.
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Cites
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,117
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
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Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
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Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
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Cited by
Endothelial/Pericyte Interactions
Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048
Molecular mechanisms of blood vessel growth
Conway, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00281-9 · Cited by 1,030
MEF2: a central regulator of diverse developmental programs
Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834
Self-citationMEF2: a calcium-dependent regulator of cell division, differentiation and death
McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)02031-x · Cited by 687
Self-citationCaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
Passier, R., Zeng, H., Frey, N., Naya, F. J., Nicol, R. L., McKinsey, T. A., Overbeek, P., Richardson, J. A., Grant, S. R., & Olson, E. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8551 · Cited by 521
Self-citation
Metadata
- Authors
- Lin, Q., Lu, J., Yanagisawa, H., Webb, R., Lyons, G. E., Richardson, J. A., & Olson, E. N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-11-15
- Volume
- 125
- Issue
- 22
- Pages
- 4565-4574
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2161322544
- Cited by
- 309
- References
- 68
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lin, Q., Lu, J., Yanagisawa, H., Webb, R., Lyons, G. E., Richardson, J. A., & Olson, E. N. (1998). Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. https://doi.org/10.1242/dev.125.22.4565
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
