The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
Abstract
We have investigated the developmental relationship of the hemopoietic and endothelial lineages in the floor of the chicken aorta, a site of hemopoietic progenitor emergence in the embryo proper. We show that, prior to the onset of hemopoiesis, the aortic endothelium uniformly expresses the endothelium-specific membrane receptor VEGF-R2. The onset of hemopoiesis can be determined by detecting the common leukocyte antigen CD45. VEGF-R2 and CD45 are expressed in complementary fashion, namely the hemopoietic cluster-bearing floor of the aorta is CD45+/VEGF-R2−, while the rest of the aortic endothelium is CD45−/VEGF-R2+. To determine if the hemopoietic clusters are derived from endothelial cells, we tagged the E2 endothelial tree from the inside with low-density lipoproteins (LDL) coupled to DiI. 24 hours later, hemopoietic clusters were labelled by LDL. Since no CD45+ cells were inserted among endothelial cells at the time of vascular labelling, hemopoietic clusters must be concluded to derive from precursors with an endothelial phenotype.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
Shivdasani, R. A., Mayer, E. L., & Orkin, S. H. (1995) · Nature · doi:10.1038/373432a0 · Cited by 938
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Robb, L., Lyons, I., Li, R., Hartley, L., Köntgen, F., Harvey, R. P., Metcalf, D., & Begley, C. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7075 · Cited by 577
Cited by
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991
Haematopoietic stem cells derive directly from aortic endothelium during development
Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,025
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
Boisset, J.-C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., & Robin, C. (2010) · Nature · doi:10.1038/nature08764 · Cited by 917
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Fate tracing reveals the endothelial origin of hematopoietic stem cells
Zovein, A. C., Hofmann, J. J., Lynch, M., French, W. J., Turlo, K. A., Yang, Y., Becker, M. S., Zanetta, L., Dejana, E., Gasson, J. C., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.018 · Cited by 691
Metadata
- Authors
- Jaffredo, T., Gautier, R., Eichmann, A., & Dieterlen-Lièvre, F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-11-15
- Volume
- 125
- Issue
- 22
- Pages
- 4575-4583
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2130422603
- Cited by
- 591
- References
- 5
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jaffredo, T., Gautier, R., Eichmann, A., & Dieterlen-Lièvre, F. (1998). Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Development. https://doi.org/10.1242/dev.125.22.4575
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
