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Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
Abstract
We have investigated the developmental relationship of the hemopoietic and endothelial lineages in the floor of the chicken aorta, a site of hemopoietic progenitor emergence in the embryo proper. We show that, prior to the onset of hemopoiesis, the aortic endothelium uniformly expresses the endothelium-specific membrane receptor VEGF-R2. The onset of hemopoiesis can be determined by detecting the common leukocyte antigen CD45. VEGF-R2 and CD45 are expressed in complementary fashion, namely the hemopoietic cluster-bearing floor of the aorta is CD45+/VEGF-R2−, while the rest of the aortic endothelium is CD45−/VEGF-R2+. To determine if the hemopoietic clusters are derived from endothelial cells, we tagged the E2 endothelial tree from the inside with low-density lipoproteins (LDL) coupled to DiI. 24 hours later, hemopoietic clusters were labelled by LDL. Since no CD45+ cells were inserted among endothelial cells at the time of vascular labelling, hemopoietic clusters must be concluded to derive from precursors with an endothelial phenotype.
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Metadata
- Authors
- Jaffredo, T., Gautier, R., Eichmann, A., & Dieterlen-Lièvre, F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-11-15
- Volume
- 125
- Issue
- 22
- Pages
- 4575-4583
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2130422603
- Cited by
- 591
- References
- 5
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- closed
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