The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
Abstract
The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo. In later developmental stages, it appears in the branchial arches, the otic and olfactory placodes and their derivatives, in restricted brain regions, in all extending appendages and in all developing bones. We have created a null allele of the mouse Dlx5 gene by replacing exons I and II with the E. coli lacZ gene. Heterozygous mice appear normal. β-galactosidase activity in Dlx5+/− embryos and newborn animals reproduces the known pattern of expression of the gene. Homozygous mutants die shortly after birth with a swollen abdomen. They present a complex phenotype characterised by craniofacial abnormalities affecting derivatives of the first four branchial arches, severe malformations of the vestibular organ, a delayed ossification of the roof of the skull and abnormal osteogenesis. No obvious defect was observed in the patterning of limbs and other appendages. The defects observed in Dlx5−/− mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation.
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Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,814
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
Robertson, E., Bradley, A., Kuehn, M., & Evans, M. (1986) · Nature · doi:10.1038/323445a0 · Cited by 751
Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny
Köntges, G., & Lumsden, A. (1996) · Development · doi:10.1242/dev.122.10.3229 · Cited by 671
Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo
Lumsden, A., Sprawson, N., & Graham, A. (1991) · Development · doi:10.1242/dev.113.4.1281 · Cited by 625
Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M. R., Nigro, V., & Boncinelli, E. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05935.x · Cited by 617
Self-citationWinged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
Xuan, S., Baptista, C. A., Balas, G., Tao, W., Soares, V. C., & Lai, E. (1995) · Neuron · doi:10.1016/0896-6273(95)90262-7 · Cited by 601
Bulfone, A., Puelles, L., Porteus, M., Frohman, M., Martin, G., & Rubenstein, J. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03155.1993 · Cited by 574
The Embryonic Vertebrate Forebrain: the Prosomeric Model
Rubenstein, J. L. R., Martinez, S., Shimamura, K., & Puelles, L. (1994) · Science · doi:10.1126/science.7939711 · Cited by 535
Cited by
A promoter-level mammalian expression atlas
The FANTOM Consortium and the RIKEN PMI and CLST (DGT) (2014) · Nature · doi:10.1038/nature13182 · Cited by 1,982
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,120
Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes & Development · doi:10.1101/gad.1416106 · Cited by 712
Minoux, M., & Rijli, F. M. (2010) · Development · doi:10.1242/dev.040048 · Cited by 507
Specification of Jaw Subdivisions by Dlx Genes
Depew, M. J., Lufkin, T., & Rubenstein, J. L. R. (2002) · Science · doi:10.1126/science.1075703 · Cited by 465
Metadata
- Authors
- Acampora, D., Merlo, G. R., Paleari, L., Zerega, B., Postiglione, M. P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., & Levi, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-09-01
- Volume
- 126
- Issue
- 17
- Pages
- 3795-3809
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2135144225
- Cited by
- 444
- References
- 36
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. https://app.cochat.ai/papers/10.1242/dev.126.17.3795
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- Acampora, D., Merlo, G. R., Paleari, L., Zerega, B., Postiglione, M. P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., & Levi, G. (1999). Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. https://doi.org/10.1242/dev.126.17.3795
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