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Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction
Abstract
Mesoderm induction and patterning are mediated by members of the TGFβ superfamily. We have isolated a novel zebrafish member, antivin, that structurally is highly related to mouse lefty. Overexpression of antivin completely abolishes mesoderm induction at blastula stage, yet resultant embryos develop well-patterned epidermal and neural derivatives. The mesoderm-inhibiting activity of antivin can be mimicked by lefty and is suppressed by increasing levels of the mesodermal inducer Activin or its receptors. On the basis of its expression and activity, we propose that Antivin normally functions as a competitive inhibitor of Activin to limit mesoderm induction in the early embryo.
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Citations
Cited by
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Regulation of TGF-β Family Signaling by Inhibitory Smads
Miyazawa, K., & Miyazono, K. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022095 · Cited by 439
The establishment of spemann's organizer and patterning of the vertebrate embryo
De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O. (2000) · Nature Reviews Genetics · doi:10.1038/35042039 · Cited by 429
Endodermal Nodal-related signals and mesoderm induction in Xenopus
Agius, E., Oelgeschläger, M., Wessely, O., Kemp, C., & Robertis, E. M. D. (2000) · Development · doi:10.1242/dev.127.6.1173 · Cited by 420
Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80331-7 · Cited by 374
Metadata
- Authors
- Thisse, C., & Thisse, B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-01-15
- Volume
- 126
- Issue
- 2
- Pages
- 229-240
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2147556163
- Cited by
- 316
- References
- 0
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thisse, C., & Thisse, B. (1999). Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction. Development. https://doi.org/10.1242/dev.126.2.229
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