The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures
Abstract
The dorsal gastrula organizer plays a fundamental role in establishment of the vertebrate axis. We demonstrate that the zebrafish bozozok (boz) locus is required at the blastula stages for formation of the embryonic shield, the equivalent of the gastrula organizer and expression of multiple organizer-specific genes. Furthermore, boz is essential for specification of dorsoanterior embryonic structures, including notochord, prechordal mesendoderm, floor plate and forebrain. We report that boz mutations disrupt the homeobox gene dharma. Overexpression of boz in the extraembryonic yolk syncytial layer of boz mutant embryos is sufficient for normal development of the overlying blastoderm, revealing an involvement of extraembryonic structures in anterior patterning in fish similarly to murine embryos. Epistatic analyses indicate that boz acts downstream of β-catenin and upstream to TGF-β signaling or in a parallel pathway. These studies provide genetic evidence for an essential function of a homeodomain protein in β-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarchy of zygotic genes specifying the dorsal midline of a vertebrate embryo.
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Cites
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465
Self-citation
Cited by
Structure and function of the notochord: an essential organ for chordate development
Stemple, D. L. (2005) · Development · doi:10.1242/dev.01812 · Cited by 443
Self-citationEndodermal Nodal-related signals and mesoderm induction in Xenopus
Agius, E., Oelgeschläger, M., Wessely, O., Kemp, C., & Robertis, E. M. D. (2000) · Development · doi:10.1242/dev.127.6.1173 · Cited by 420
Long, S., Ahmad, N., & Rebagliati, M. (2003) · Development · doi:10.1242/dev.00436 · Cited by 366
Lekven, A. C., Thorpe, C. J., Waxman, J. S., & Moon, R. T. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00007-7 · Cited by 349
Heisenberg, C.-P., Houart, C., Take-uchi, M., Rauch, G.-J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M. L., Geisler, R., et al. (2001) · Genes & Development · doi:10.1101/gad.194301 · Cited by 265
Self-citationThe words of the regulatory code are arranged in a variable manner in highly conserved enhancers
Rastegar, S., Hess, I., Dickmeis, T., Nicod, J. C., Ertzer, R., Hadzhiev, Y., Thies, W.-G., Scherer, G., & Strähle, U. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.034 · Cited by 56
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FoxA transcription factors are essential for the development of dorsal axial structures
Dal-Pra, S., Thisse, C., & Thisse, B. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.018 · Cited by 35
Metadata
- Authors
- Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H. I., Topczewski, J., Gates, M. A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A. F., Driever, W., Hirano, T., Talbot, W. S., & Solnica-Krezel, L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-04-01
- Volume
- 126
- Issue
- 7
- Pages
- 1427-1438
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2096614956
- Cited by
- 198
- References
- 2
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
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