The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development
Abstract
The precursors of several organs reside within the lateral plate mesoderm of vertebrate embryos. Here, we demonstrate that the zebrafish hands off locus is essential for the development of two structures derived from the lateral plate mesoderm-the heart and the pectoral fin. hands off mutant embryos have defects in myocardial development from an early stage: they produce a reduced number of myocardial precursors, and the myocardial tissue that does form is improperly patterned and fails to maintain tbx5 expression. A similar array of defects is observed in the differentiation of the pectoral fin mesenchyme: small fin buds form in a delayed fashion, anteroposterior patterning of the fin mesenchyme is absent and tbx5 expression is poorly maintained. Defects in these mesodermal structures are preceded by the aberrant morphogenesis of both the cardiogenic and forelimbforming regions of the lateral plate mesoderm. Molecular analysis of two hands off alleles indicates that the hands off locus encodes the bHLH transcription factor Hand2, which is expressed in the lateral plate mesoderm starting at the completion of gastrulation. Thus, these studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
Basson, C. T., Bachinsky, D. R., Lin, R. C., Levi, T., Elkins, J. A., Soults, J., Grayzel, D., Kroumpouzou, E., Traill, T. A., Leblanc-Straceski, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0197-30 · Cited by 1,093
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,077
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
Yi Li, Q., Newbury-Ecob, R. A., Terrett, J. A., Wilson, D. I., Curtis, A. R. J., Ho Yi, C., Gebuhr, T., Bullen, P. J., Robson, S. C., Strachan, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0197-21 · Cited by 927
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
Bader, D., Masaki, T., & Fischman, D. A. (1982) · The Journal of cell biology · doi:10.1083/jcb.95.3.763 · Cited by 919
Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D., & Olson, E. N. (1997) · Nature Genetics · doi:10.1038/ng0697-154 · Cited by 726
A role for bone morphogenetic proteins in the induction of cardiac myogenesis.
Schultheiss, T. M., Burch, J. B., & Lassar, A. B. (1997) · Genes & Development · doi:10.1101/gad.11.4.451 · Cited by 687
The roles of FGFs in the early development of vertebrate limbs
Martin, G. R. (1998) · Genes & Development · doi:10.1101/gad.12.11.1571 · Cited by 648
Hollenberg, S. M., Sternglanz, R., Cheng, P. F., & Weintraub, H. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3813 · Cited by 647
Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
Stainier, D. Y. R., Fouquet, B., Chen, J.-N., Warren, K. S., Weinstein, B. M., Meiler, S. E., Mohideen, M.-A. P. K., Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A. F., et al. (1996) · Development · doi:10.1242/dev.123.1.285 · Cited by 624
Self-citationAkimenko, M., Ekker, M., Wegner, J., Lin, W., & Westerfield, M. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03475.1994 · Cited by 607
Molecular Models for Vertebrate Limb Development
Johnson, R. L., & Tabin, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80364-5 · Cited by 580
A Subclass of bHLH Proteins Required for Cardiac Morphogenesis
Srivastava, D., Cserjesi, P., & Olson, E. N. (1995) · Science · doi:10.1126/science.270.5244.1995 · Cited by 547
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
Riley, P., Anaon-Cartwight, L., & Cross, J. C. (1998) · Nature Genetics · doi:10.1038/ng0398-271 · Cited by 531
Kishimoto, Y., Lee, K.-H., Zon, L., Hammerschmidt, M., & Schulte-Merker, S. (1997) · Development · doi:10.1242/dev.124.22.4457 · Cited by 519
Yelon, D., Horne, S. A., & Stainier, D. Y. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9406 · Cited by 482
Self-citationMutations affecting the cardiovascular system and other internal organs in zebrafish
Chen, J.-N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.293 · Cited by 444
Gata5 is required for the development of the heart and endoderm in zebrafish
Reiter, J. F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., & Stainier, D. Y. R. (1999) · Genes & Development · doi:10.1101/gad.13.22.2983 · Cited by 421
Self-citationFirulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D., & Olson, E. N. (1998) · Nature Genetics · doi:10.1038/ng0398-266 · Cited by 386
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
Schauerte, H. E., Eeden, F. J. M. V., Fricke, C., Odenthal, J., Strähle, U., & Haffter, P. (1998) · Development · doi:10.1242/dev.125.15.2983 · Cited by 349
Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation
Chen, J., & Fishman, M. C. (1996) · Development · doi:10.1242/dev.122.12.3809 · Cited by 329
Biben, C., & Harvey, R. P. (1997) · Genes & Development · doi:10.1101/gad.11.11.1357 · Cited by 323
Cross, J. C., Flannery, M. L., Blanar, M. A., Steingrimsson, E., Jenkins, N. A., Copeland, N. G., Rutter, W. J., & Werb, Z. (1995) · Development · doi:10.1242/dev.121.8.2513 · Cited by 313
A Molecular Pathway Revealing a Genetic Basis for Human Cardiac and Craniofacial Defects
Yamagishi, H., Garg, V., Matsuoka, R., Thomas, T., & Srivastava, D. (1999) · Science · doi:10.1126/science.283.5405.1158 · Cited by 277
The development of the paired fins in the zebrafish (Danio rerio).
Grandel, H., & Schulte-Merker, S. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00176-2 · Cited by 267
Reifers, F., Walsh, E. C., Léger, S., Stainier, D. Y. R., & Brand, M. (2000) · Development · doi:10.1242/dev.127.2.225 · Cited by 262
Self-citationA radiation hybrid map of the zebrafish genome
Geisler, R., Rauch, G.-J., Baier, H., van Bebber, F., Broβ, L., Dekens, M. P. S., Finger, K., Fricke, C., Gates, M. A., Geiger, H., et al. (1999) · Nature Genetics · doi:10.1038/12692 · Cited by 252
Cserjesi, P., Brown, D., Lyons, G. E., & Olson, E. N. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1245 · Cited by 250
SEGREGATION ANALYSES AND GENE-CENTROMERE DISTANCES IN ZEBRAFISH
Streisinger, G., Singer, F., Walker, C., Knauber, D., & Dower, N. (1986) · Genetics · doi:10.1093/genetics/112.2.311 · Cited by 245
Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4
Bao, Z.-Z., Bruneau, B. G., Seidman, J. G., Seidman, C. E., & Cepko, C. L. (1999) · Science · doi:10.1126/science.283.5405.1161 · Cited by 245
Patterning the zebrafish heart tube: Acquisition of anteroposterior polarity
Stainier, D. Y. R., & Fishman, M. C. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90094-w · Cited by 223
Self-citationTbx5 is essential for heart development
Horb, M. E., & Thomsen, G. H. (1999) · Development · doi:10.1242/dev.126.8.1739 · Cited by 218
Cardiac Expression of the Ventricle-Specific Homeobox Gene Irx4 Is Modulated by Nkx2-5 and dHand
Bruneau, B. G., Bao, Z.-Z., Tanaka, M., Schott, J.-J., Izumo, S., Cepko, C. L., Seidman, J. G., & Seidman, C. E. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9548 · Cited by 207
Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development
Gibson-Brown, J. J., Agulnik, S. I., Silver, L. M., Niswander, L., & Papaioannou, V. E. (1998) · Development · doi:10.1242/dev.125.13.2499 · Cited by 177
Self-citationLogan, M., Simon, H.-G., & Tabin, C. (1998) · Development · doi:10.1242/dev.125.15.2825 · Cited by 173
Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning
Alexander, J. S., Stainier, D. Y. R., & Yelon, D. L. (1998) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1998)22:3<288::aid-dvg10>3.0.co;2-2 · Cited by 171
Self-citationLee, K.-H., Xu, Q., & Breitbart, R. E. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0341 · Cited by 168
Tbx genes and limb identity in chick embryo development
Isaac, A., Rodrı́guez-Esteban, C., Ryan, A. K., Altabef, M., Tsukui, T., Patel, K., Tickle, C. A., & Izpisúa‐Belmonte, J. C. (1998) · Development · doi:10.1242/dev.125.10.1867 · Cited by 151
A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart
Xavier‐Neto, J., Neville, C. M., Shapiro, M. D., Houghton, L., Wang, G. F., Nikovits, W., Stockdale, F. E., & Rosenthal, N. A. (1999) · Development · doi:10.1242/dev.126.12.2677 · Cited by 144
Chazaud, C., Chambon, P., & Dollé, P. (1999) · Development · doi:10.1242/dev.126.12.2589 · Cited by 137
Regulation in the heart field of zebrafish
Serbedzija, G. N., Chen, J., & Fishman, M. C. (1998) · Development · doi:10.1242/dev.125.6.1095 · Cited by 127
Neumann, C. J., Grandel, H., Gaffield, W., Schulte‐Merker, S., & Nüsslein‐Volhard, C. (1999) · Development · doi:10.1242/dev.126.21.4817 · Cited by 123
Ohuchi, H., Takeuchi, J., Yoshioka, H., Ishimaru, Y., Ogura, K., Takahashi, N., Ogura, T., & Noji, S. (1998) · Development · doi:10.1242/dev.125.1.51 · Cited by 122
Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I.
Johnson, S. L., Africa, D., Horne, S., & Postlethwait, J. H. (1995) · Genetics · doi:10.1093/genetics/139.4.1727 · Cited by 115
Developmental regulation of Tbx5 in zebrafish embryogenesis
Begemann, G., & Ingham, P. W. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00246-4 · Cited by 98
HAND Proteins Molecular Mediators of Cardiac Development and Congenital Heart Disease
Srivastava, D. (1999) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(98)00033-4 · Cited by 98
The evolution of paired appendages in vertebrates: T-box genes in the zebrafish
Ruvinsky, I., Oates, A. C., Silver, L. M., & Ho, R. K. (2000) · Development Genes and Evolution · doi:10.1007/s004270050014 · Cited by 97
Self-citationAngelo, S., Lohr, J. L., Lee, K. H., Ticho, B. S., Breitbart, R. E., Hill, S., Yost, H. J., & Srivastava, D. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00334-8 · Cited by 90
Self-citationGriffin, K. J. P., Stoller, J. Z., Gibson, M. C., Chen, S., Yelon, D. L., Stainier, D. Y. R., & Kimelman, D. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9571 · Cited by 79
Self-citationDifferential expression of Tbx4 and Tbx5 in Zebrafish Fin buds
Tamura, K., Yonei‐Tamura, S., & Belmonte, J. C. I. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00126-4 · Cited by 73
Notochord Regulates Cardiac Lineage in Zebrafish Embryos
Goldstein, A. M., & Fishman, M. C. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8976 · Cited by 63
Generation of a Zebrafish P1 Artificial Chromosome Library
Amemiya, C. T., & Zon, L. I. (1999) · Genomics · doi:10.1006/geno.1999.5827 · Cited by 50
Wilson, G. N. (1998) · PubMed · Cited by 38
Imai, Y., Feldman, B., Schier, A. F., & Talbot, W. S. (2000) · Genetics · doi:10.1093/genetics/155.1.261 · Cited by 28
Cited by
Gene Regulatory Networks in the Evolution and Development of the Heart
Olson, E. N. (2006) · Science · doi:10.1126/science.1132292 · Cited by 1,015
Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 833
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
A genetic blueprint for cardiac development
Srivastava, D., & Olson, E. N. (2000) · Nature · doi:10.1038/35025190 · Cited by 631
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Metadata
- Authors
- Yelon, D., Ticho, B., Halpern, M. E., Ruvinsky, I., Ho, R. K., Silver, L. M., & Stainier, D. Y. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-06-15
- Volume
- 127
- Issue
- 12
- Pages
- 2573-2582
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143149809
- Cited by
- 334
- References
- 53
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
