The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Loss of connexin45 causes a cushion defect in early cardiogenesis
Abstract
At around embryonic day 9, the primitive heart of a mouse embryo undergoes spectacular alterations within 24 hours. We created mice harboring an nls-lacZ gene in place of connexin45, which encodes the only known gap junction protein in the primitive heart before embryonic day 9, using the Cre-loxP system. Connexin45-deficient mice died of heart failure at around embryonic day 10. They initiated heart contractions, but conduction block appeared within 24 hours after the first contractions. Their cardiac walls displayed an endocardial cushion defect, while the cardiac jelly was present. These abnormalities were caused by impairment of the epithelial-mesenchymal transformation of the cardiac endothelium. Activation of the cardiac endothelium depended on the presence of the connexin45 gap junctions since signaling through Ca2+/calcineurin and NF-ATc1 (originally named NF-ATc) was disrupted in the mutant hearts. These results indicate a requirement for gap junction channels during early cardiogenesis and hence implicate connexin45 in congenital heart diseases. Movies available on-line: http://www.biologists.com/Development/movies/dev4369.html
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structural development of endocardial cushions
Markwald, R. R., Fitzharris, T. P., & Manasek, F. J. (1977) · American Journal of Anatomy · doi:10.1002/aja.1001480108 · Cited by 489
Cited by
Transcriptional regulation by calcium, calcineurin, and NFAT
Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991
Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323
Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome
Willecke, K., Eiberger, J., Degen, J., Eckardt, D., Romualdi, A., Güldenagel, M., Deutsch, U., & Söhl, G. (2002) · Biological Chemistry · doi:10.1515/bc.2002.076 · Cited by 1,158
Gap junctions and the connexin protein family
SOHL, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.013 · Cited by 991
Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
Akiyama, H., Chaboissier, M.-C., Behringer, R. R., Rowitch, D. H., Schedl, A., Epstein, J. A., & de Crombrugghe, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401711101 · Cited by 265
Kanady, J. D., Dellinger, M. T., Munger, S. J., Witte, M. H., & Simon, A. M. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.004 · Cited by 184
The Impact of Mechanical Forces in Heart Morphogenesis
Granados-Riveron, J. T., & Brook, J. D. (2012) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.111.961086 · Cited by 90
Connexins in lymphatic vessel physiology and disease
Meens, M. J., Sabine, A., Petrova, T. V., & Kwak, B. R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.01.011 · Cited by 44
Metadata
- Authors
- Kumai, M., Nishii, K., Nakamura, K.-I., Takeda, N., Suzuki, M., & Shibata, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-08-15
- Volume
- 127
- Issue
- 16
- Pages
- 3501-3512
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2164602163
- Cited by
- 206
- References
- 1
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
