The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest
Abstract
BMP signaling is essential for a wide variety of developmental processes. To evaluate the role of Bmp2/4 in cranial neural crest (CNC) formation or differentiation after its migration into the branchial arches, we used Xnoggin to block their activities in specific areas of the CNC in transgenic mice. This resulted in depletion of CNC cells from the targeted areas. As a consequence, the branchial arches normally populated by the affected neural crest cells were hypomorphic and their skeletal and neural derivatives failed to develop. In further analyses, we have identified Bmp2 as the factor required for production of migratory cranial neural crest. Its spatial and temporal expression patterns mirror CNC emergence and Bmp2 mutant embryos lack both branchial arches and detectable migratory CNC cells. Our results provide functional evidence for an essential role of BMP signaling in CNC development.
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Cites
Functional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578
Cited by
Is obesity an inflammatory condition?
Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00672-4 · Cited by 799
Cranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
BMP signaling in mesenchymal stem cell differentiation and bone formation
Beederman, M., Lamplot, J. D., Nan, G., Wang, J., Liu, X., Yin, L., Li, R., Shui, W., Zhang, H., Kim, S. H., et al. (2013) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2013.68a1004 · Cited by 318
Depew, M. J., Tucker, A. S., & Sharpe, P. T. (2002) · Mouse Development · doi:10.1016/b978-012597951-1/50023-8 · Cited by 259
Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2
Styrkarsdottir, U., Cazier, J.-B., Kong, A., Rolfsson, O., Larsen, H., Bjarnadottir, E., Johannsdottir, V. D., Sigurdardottir, M. S., Bagger, Y., Christiansen, C., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000069 · Cited by 248
Metadata
- Authors
- Kanzler, B., Foreman, R. K., Labosky, P. A., & Mallo, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-03-01
- Volume
- 127
- Issue
- 5
- Pages
- 1095-1104
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2185661130
- Cited by
- 182
- References
- 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
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