The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
Abstract
Development of the vertebrate nervous system requires the actions of transcription factors that establish regional domains of gene expression, which results in the generation of diverse neuronal cell types. MATH1, a transcription factor of the bHLH class, is expressed during development of the nervous system in multiple neuronal domains, including the dorsal neural tube, the EGL of the cerebellum and the hair cells of the vestibular and auditory systems. MATH1 is essential for proper development of the granular layer of the cerebellum and the hair cells of the cochlear and vestibular systems, as shown in mice carrying a targeted disruption of Math1. Previously, we showed that 21 kb of sequence flanking the Math1-coding region is sufficient for Math1 expression in transgenic mice. Here we identify two discrete sequences within the 21 kb region that are conserved between mouse and human, and are sufficient for driving a lacZ reporter gene in these domains of Math1 expression in transgenic mice. The two identified enhancers, while dissimilar in sequence, appear to have redundant activities in the different Math1 expression domains except the spinal neural tube. The regulatory mechanisms for each of the diverse Math1 expression domains are tightly linked, as separable regulatory elements for any given domain of Math1 expression were not found, suggesting that a common regulatory mechanism controls these apparently unrelated domains of expression. In addition, we demonstrate a role for autoregulation in controlling the activity of the Math1 enhancer, through an essential E-box consensus binding site.
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Cites
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Self-citationTRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS
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Self-citationConversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
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Cited by
Math1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors
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Math1-driven GFP expression in the developing nervous system of transgenic mice
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Self-citationRegulatory divergence modifies limb length between mammals
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Metadata
- Authors
- Helms, A. W., Abney, A. L., Ben-Arie, N., Zoghbi, H. Y., & Johnson, J. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-03-15
- Volume
- 127
- Issue
- 6
- Pages
- 1185-1196
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1898205487
- Cited by
- 289
- References
- 65
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
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