The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
Abstract
The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.
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Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Cobb, M. H., & Goldsmith, E. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14843 · Cited by 1,719
Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R., & Schlessinger, J. (1997) · Science · doi:10.1126/science.276.5314.955 · Cited by 1,097
Palmeirim, I., Henrique, D., Ish-Horowicz, D., & Pourquié, O. (1997) · Cell · doi:10.1016/s0092-8674(00)80451-1 · Cited by 948
Cooke, J., & Zeeman, E. C. (1976) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(76)80131-2 · Cited by 784
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.
Yamaguchi, T. P., Harpal, K., Henkemeyer, M., & Rossant, J. (1994) · Genes & Development · doi:10.1101/gad.8.24.3032 · Cited by 778
Reifers, F., Böhli, H., Walsh, E. C., Crossley, P. H., Stainier, D. Y. R., & Brand, M. (1998) · Development · doi:10.1242/dev.125.13.2381 · Cited by 686
Dubrulle, J., McGrew, M. J., & Pourquié, O. (2001) · Cell · doi:10.1016/s0092-8674(01)00437-8 · Cited by 667
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
Sun, X., Meyers, E. N., Lewandoski, M., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.14.1834 · Cited by 651
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Dubrulle, J., & Pourquié, O. (2004) · Nature · doi:10.1038/nature02216 · Cited by 417
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
van den Brink, S. C., Alemany, A., van Batenburg, V., Moris, N., Blotenburg, M., Vivié, J., Baillie-Johnson, P., Nichols, J., Sonnen, K. F., Martinez Arias, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2024-3 · Cited by 404
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
Corson, L. B., Yamanaka, Y., Lai, K.-M. V., & Rossant, J. (2003) · Development · doi:10.1242/dev.00669 · Cited by 390
The Structural Biology of the FGF19 Subfamily
Beenken, A., & Mohammadi, M. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-0887-1_1 · Cited by 93
Metadata
- Authors
- Sawada, A., Shinya, M., Jiang, Y.-J., Kawakami, A., Kuroiwa, A., & Takeda, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-12-01
- Volume
- 128
- Issue
- 23
- Pages
- 4873-4880
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2140800916
- Cited by
- 304
- References
- 28
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sawada, A., Shinya, M., Jiang, Y.-J., Kawakami, A., Kuroiwa, A., & Takeda, H. (2001). Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development. https://doi.org/10.1242/dev.128.23.4873
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
