The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Building and re-building the heart by cardiomyocyte proliferation
Open accessAbstract
The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal arrhythmias and heart failure. The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can avidly proliferate during fetal and neonatal development, and both adult zebrafish and neonatal mice can regenerate cardiac muscle after injury, suggesting that latent regenerative potential exists. Dissecting the cellular and molecular mechanisms that promote cardiomyocyte proliferation throughout life, deciphering why proliferative capacity normally dissipates in adult mammals, and deriving means to boost this capacity are primary goals in cardiovascular research. Here, we review our current understanding of how cardiomyocyte proliferation is regulated during heart development and regeneration.
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Cites
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Cited by
Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish
González-Rosa, J. M., Sharpe, M., Field, D., Soonpaa, M. H., Field, L. J., Burns, C. E., & Burns, C. G. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.021 · Cited by 264
Age mosaicism across multiple scales in adult tissues
Arrojo e Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T., Bushong, E., Phan, S., Orphan, V., Lechene, C., Ellisman, M. H., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.010 · Cited by 137
Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
Huang, W., Feng, Y., Liang, J., Yu, H., Wang, C., Wang, B., Wang, M., Jiang, L., Meng, W., Cai, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03019-z · Cited by 139
Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise
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Metadata
- Authors
- Foglia, M. J., & Poss, K. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2016-03-01
- Volume
- 143
- Issue
- 5
- Pages
- 729-740
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2288495517
- Cited by
- 242
- References
- 10
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
