Cited by 381Congenital heart defects researchNeurogenesis and neuroplasticity mechanismsCardiac Fibrosis and Remodeling

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

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Tian, Ying, Liu, Ying, Wang, Tao, Zhou, Ning, Kong, Jun, Chen, Li, Snitow, Melinda, Morley, Michael +8 more·2015·Science Translational Medicine

Abstract

A microRNA-based therapeutic approach could be used to promote cardiac regeneration through the transient activation of cardiomyocyte proliferation.

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Crossref · 10.1126/scitranslmed.3010841

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Authors
Tian, Y., Liu, Y., Wang, T., Zhou, N., Kong, J., Chen, L., Snitow, M., Morley, M., Li, D., Petrenko, N., Zhou, S., Lu, M., Gao, E., Koch, W. J., Stewart, K. M., & Morrisey, E. E.
Affiliations
  • University of Pennsylvania (US)
  • Tang Du Hospital (CN)
  • Temple University (US)
Corresponding author
  • Tian, Ying
  • Morrisey, Edward E.
Venue
Science Translational Medicine
Published
2015-03-18
Volume
7
Issue
279
Pages
279ra38-279ra38
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2140775408
Cited by
381
References
42
Citations by year
2026: 10 · 2025: 27 · 2024: 36 · 2023: 36 · 2022: 35 · 2021: 43 · 2020: 45 · 2019: 41 · 2018: 28 · 2017: 40 · 2016: 26 · 2015: 14
FWCI
15.54
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (R01-HL064632, R01-HL087825, U01-HL100405, K99/R00-HL111348)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
cardiomyocyte proliferation, cardiac regeneration, Hippo signaling pathway, myocardial infarction, myocardial fibrosis, cardiomyocyte dedifferentiation, miRNA-based therapy, cardiac repair, cell cycle re-entry, heart development
MeSH terms
Hippo Signaling Pathway, Alleles, Animals, Cell Cycle, Cell Separation, Cells, Cultured, Flow Cytometry, Heart, Humans, Lipids, Male, Myocardial Infarction, Regeneration, Signal Transduction, Lentivirus, Protein Serine-Threonine Kinases, Myocytes, Cardiac, MicroRNAs, Cell Proliferation, Mice, HEK293 Cells

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