A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
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A microRNA-based therapeutic approach could be used to promote cardiac regeneration through the transient activation of cardiomyocyte proliferation.
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Recent pre-clinical evidence indicates that Hippo pathway inhibiting miRNAs can stimulate CM proliferation.
“Recent pre-clinical evidence indicates that Hippo pathway inhibiting miRNAs can stimulate CM proliferation34,57,58.”
From 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels (2021) · cites this paper as [57]
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- Authors
- Tian, Y., Liu, Y., Wang, T., Zhou, N., Kong, J., Chen, L., Snitow, M., Morley, M., Li, D., Petrenko, N., Zhou, S., Lu, M., Gao, E., Koch, W. J., Stewart, K. M., & Morrisey, E. E.
- Affiliations
- University of Pennsylvania (US)
- Tang Du Hospital (CN)
- Temple University (US)
- Corresponding author
- Tian, Ying
- Morrisey, Edward E.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-03-18
- Volume
- 7
- Issue
- 279
- Pages
- 279ra38-279ra38
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6295313
- OpenAlex
- W2140775408
- Cited by
- 381
- References
- 42
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 36 · 2023: 36 · 2022: 35 · 2021: 43 · 2020: 45 · 2019: 41 · 2018: 28 · 2017: 40 · 2016: 26 · 2015: 14
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01-HL064632, R01-HL087825, U01-HL100405, K99/R00-HL111348)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- cardiomyocyte proliferation, cardiac regeneration, Hippo signaling pathway, myocardial infarction, myocardial fibrosis, cardiomyocyte dedifferentiation, miRNA-based therapy, cardiac repair, cell cycle re-entry, heart development
- MeSH terms
- Hippo Signaling Pathway, Alleles, Animals, Cell Cycle, Cell Separation, Cells, Cultured, Flow Cytometry, Heart, Humans, Lipids, Male, Myocardial Infarction, Regeneration, Signal Transduction, Lentivirus, Protein Serine-Threonine Kinases, Myocytes, Cardiac, MicroRNAs, Cell Proliferation, Mice, HEK293 Cells
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