Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells
Open accessAbstract
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and impaired regeneration. Here, we identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells [SCs]) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC quiescence, with long-term expansion of a regeneration-proficient SC pool. These SCs have an incomplete disruption of the myofiber-SC adhesive junction and maintain niche residence and cell polarity, yet show properties of SCs in a state of transition from quiescence toward full activation. Among these is nuclear localization of β-catenin, which is necessary for this phenotype. Injury-induced perturbation of niche adhesive junctions is therefore a likely first step in the quiescence-to-activation transition.
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Diminishment of the SC pool is not observed when SCs-SC niche molecular interactions are interrupted in muscles lacking Wnt4, N-, and M-cadherins or syndecan-3.
“Interestingly, diminishment of the SC pool is not observed when SCs-SC niche molecular interactions are interrupted in muscles lacking Wnt4, N-, and M-cadherins or syndecan-323,39,40.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [39]
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“Consistent with the notion that quiescence is essential for adult stem cell preservation, deregulation of quiescence in muscle stem cells during tissue homeostasis, leads to their depletion through apoptosis, precocious differentiation or incorporation into the center of the muscle fiber-reminiscent of a regenerative…”
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- Authors
- Goel, A. J., Rieder, M.-K., Arnold, H.-H., Radice, G. L., & Krauss, R. S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Technische Universität Braunschweig (DE)
- Thomas Jefferson University (US)
- Corresponding author
- Krauss, Robert S.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 21
- Issue
- 8
- Pages
- 2236-2250
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5702939
- OpenAlex
- W2770114366
- Cited by
- 146
- References
- 67
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 27 · 2023: 11 · 2022: 19 · 2021: 20 · 2020: 19 · 2019: 14 · 2018: 3
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Medicine Forum (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (AR070231, AR046207)
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- muscle stem cells, satellite cells, N-cadherin, M-cadherin, cadherin-mediated adhesion, β-catenin nuclear localization, muscle regeneration, tissue damage, stem cell depletion, cell polarity
- MeSH terms
- Animals, Cell Division, Regeneration, Stem Cells, Signal Transduction, Cadherins, Cell Polarity, Muscle, Skeletal, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice
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